分会

第四十五分会：纳米生物分析与纳米药物化学

摘要

Intracellular Ca2+ ions as second messenger played key role in cell behavior, which was often overlooked in traditional antitumor treatment. Disrupting Ca2+ ions homeostasis by Ca2+ overload might switch ions signal from “regulating” to “destroying”. Inspired by this, we developed a biomimetic Ca2+ nanogenerator based on mesoporous calcium carbonate nanoparticles (MCC NPs) by curcumin (CUR) loading and further platelets (PLT) membrane coating. Upon reaching tumor cells by PLT membrane mediated tumor targeting effect, PLT@MCC/CUR would instantaneously decompose in acidic lysosomes, concurrently accompanying with Ca2+ generation and CUR release. The CUR could further facilitate Ca2+ release from endoplasmic reticulum and inhibit Ca2+ efflux, aggravating Ca2+ overload to disrupt mitochondrial Ca2+ homeostasis for mitochondria apoptosis signaling pathway activation. Interestingly, such effect was ineffective in normal cells, realizing the tumor-specific therapeutic therapy. Based on ions interference strategy, PLT@MCC/CUR herein offered synergistic combination of Ca2+ overload therapy and chemotherapy, which would pave the way toward more effective nanotherapeutics.

关键词

ions interference;biomimetic;calcium overload;calcium carbonate;curcumin

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