分会

第四十六分会：纳米材料的合成与组装

摘要

Ag2S量子点修饰的自组装二维肽纳米片的仿生合成及应用 栾欣1，魏刚1,* 1青岛大学化学与化工学院，青岛市市南区宁夏路308号 266071； *Email: weigroup@qdu.edu.cn 光热诊疗的基本原理是将光敏剂或纳米材料靶向递送至肿瘤细胞表面，然后利用近红外光的组织穿透特性诱导光敏剂激发，将光能转化为热能，并进行近红外成像，同时达到局部加热细胞内蛋白，破坏肿瘤细胞的目的1。近年来，基于近红光照射的具有光热特性的纳米材料在生物医学领域显示出极好的潜力。迄今为止，已经开发出一系列性能优异的光热纳米材料，例如碳基材料、金属硫化物和磁性纳米粒子。其中，具有光热疗法特性的Ag2S量子点由于其优异的近红外荧光特性和生物相容性，在生物医学应用中展现出巨大的潜力。然而，单一功能的光热转换材料已不能满足当前肿瘤治疗的需要，多功能、性质可调的生物纳米材料将具有更重要的研究意义2。由于肽对各种材料具有很高的亲和力，多肽和其他材料形成的复合材料不仅具有多肽材料的高生物相容性，而且具有引入材料的独特特性3。因此，利用多肽分子的高生物相容性、可降解性、自组装性和仿生合成等优势，可以在一定程度上解决复合材料在肿瘤光热和荧光成像中的难题。在这个项目中，我们通过多肽分子氨基酸序列的可控设计和功能调控合成了具有仿生能力的二维肽纳米片。然后我们以硫醇封端的聚乙二醇作为稳定剂在水相中制备了聚乙二醇化 Ag2S量子点。通过精确控制反应条件，我们获得了发射峰在 1050 nm 左右的高发射聚乙二醇化 Ag2S 量子点，最后通过仿生合成方法制备了负载Ag2S的二维复合材料，用于体内光热治疗和生物成像。该研究具有广阔的生物医学应用前景。 Fig. 1 Schematic diagram of the synthesis and application of peptide nanosheets loaded with PEGylated Ag2S QDs. 关键词：多肽；硫化银纳米粒子；光热治疗；生物成像 致谢 感谢国家自然科学基金（No.51873225）、山东省泰山学者计划（No.tsqn201909104）和青岛大学高层次人才计划的资助。 参考文献 [1] Luan, X.; Kong, H.; He, P.; Yang, G. Z.; Zhu, D. Z. Small 2023, 19 (3). [2] Kong, H.; Han, J.; Yang, M. ; Lai, L. J. Mater. Chem. B 2023 [3] He, P.; Yang, G.; Zhu D. Kong,H. J. Nanobiotechnology 2022, 20: 483 Biomimetic synthesis and application of Ag2S QDs-modified self-assembled two-dimensional peptide nanosheets Xin Luan1, Gang Wei1, * 1 College of Chemistry and Chemical Engineering, Qingdao University, No. 308 Ningxia road, Shinan district, Qingdao 266071 *Email: weigroup@qdu.edu.cn The basic principle of photothermal therapy is to deliver photosensitizers or nanomaterials to the surface of tumor cells, and then use the tissue penetration properties of near-infrared (NIR) light to induce the excitation of photosensitizers, convert light energy into heat energy1. At the same time, it achieves the purpose of locally heating intracellular proteins and destroying tumor cells. In recent years, nanomaterials with photothermal properties based on NIR light irradiation have shown excellent potential in the field of biomedicine. So far, a series of photothermal nanomaterials with excellent properties have been developed, such as carbon-based material, metal sulfides, and magnetic nanoparticles. Among them, Ag2S QDs with photothermal properties have shown great potential in biomedical applications due to their excellent NIR fluorescence properties and biocompatibility. However, single-function photothermal conversion materials can no longer meet the needs of current tumor treatment, and bionanomaterials with multiple functions and adjustable properties will have more important research significance2. Due to the high affinity of peptides for various materials, the composite materials formed by peptides and other materials not only have the high biocompatibility of peptide materials but also have the unique characteristics of the introduced materials3. Therefore, using the advantages of peptide molecules can solve the problems of composite materials in tumor photothermal and fluorescence imaging to a certain extent. In this project, we synthesized two-dimensional peptide nanosheets with biomimetic capabilities through the controllable design and functional regulation of the amino acid sequence of peptide molecules. We then prepared PEGylated Ag2S QDs in an aqueous phase with thiol-terminated polyethylene glycol as a stabilizer. By precisely controlling the reaction conditions, we obtained high-emission PEGylated Ag2S QDs with emission peaks around 1050 nm, and finally prepared two-dimensional composites loaded with Ag2S for in vivo photothermal therapy and bioimaging. This study has broad prospects for biomedical applications.

关键词

多肽;硫化银量子点;光热诊疗;生物成像;二维材料

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