Development of Green Catalyst Systems in Synthetic Organic Chemistry Toward Sustainable Society
October 12, 2019

Synthetic organic chemistry has contributed a lot to modern society. Toward future sustainable society, we are investigating on environment, human health, and energy issues from viewpoints of synthetic organic chemistry. The use of water in place of organic solvents in organic transformations, continuous-flow synthesis, and hydrogen storage and transport for a new energy in future society are current major topics. In these works, novel green catalyst systems play key roles.
A homogenized combination of nickel-based Lewis acid–surfactant-combined catalysts (LASCs) and single-walled carbon nanotubes (SWNTs) is shown to exhibit excellent activity in water. The electrochemical behaviour of the central metal was modified to address the inherently low Lewis acidity of metal cations. In addition to the enhanced reactivity, stereoselective performance and long-term stability were demonstrated in asymmetric conjugate addition reactions of aldoximes to furnish chiral nitrones in high yields with excellent selectivities. The practical and straightforward application of the designed catalysts in water provides an expedient, environmentally benign, and highly efficient pathway to access optically active compounds.1
In this lecture, other topics using heterogeneous catalysts and flow chemistry will be also discussed.2,3


[1] T. Kitanosono, P. Xu, S. Kobayashi, Science 2018, 362, 311.
[2] a) H. Miyamura, A. Suzuki, T. Yasukawa, S. Kobayashi, J. Am. Chem. Soc. 2018, 140, 11325. b) H. Miyamura, F. Tobita, A. Suzuki, S. Kobayashi, Angew. Chem. Int. Ed. 2019, 48, 9220. c) H. Ishitani, K. Kanai. W.-J. Yoo, T. Yoshida, S. Kobayashi, Angew. Chem. Int. Ed. d) T. Yasukawa, R. Masuda, S. Kobayashi, Nature Catalysis in press.  
[3] S. Kobayashi, Chem. Asian J. 2016, 11, 425.





Shu Kobayashi
University of Tokyo

Shu Kobayashi studied at The University of Tokyo, receiving his Ph.D. in 1988 working under the direction of Professor T. Mukaiyama. Following an initial period as assistant professor, he was promoted to lecturer then associate professor at Science University of Tokyo (SUT). In 1998, he moved to the Graduate School of Pharmaceutical Sciences, The University of Tokyo, as full professor. In 2007, he was appointed to his current position as professor of organic chemistry in the Department of Chemistry, Faculty of Science, The University of Tokyo. Professor Kobayashi held various visiting professorships, including the Universite Louis Pasteur, Strasbourg (1993), Kyoto University (1995), Nijmegen University (1996), Philipps-University of Marburg (1997), Paris-Sud (2010), and ESPCI (2016). Professor Kobayashi has wide-ranging research interests that include the development of new synthetic methods and novel catalysts, organic reactions in water, solid-phase and flow synthesis, total synthesis of biologically interesting compounds, and organometallic chemistry. He has held numerous named lectureships and is a recipient of many prestigious awards, including the Chemical Society of Japan Award for Young Chemists (1991), Springer Award in Organometallic Chemistry (1997), IBM Science Award (2001), Organic Reactions Lecturer (2002), Nagoya Silver Medal (2002), Mitsui Chemical Catalysis Science Award (2005), JSPS Prize (2005), the Arthur C. Cope Scholar Award from the American Chemical Society (2006), Howard Memorial Lecturer (2006), C.S. Hamilton Award (2006), Merck-Cambridge Lecturer (2007), Boehringer Ingelheim Lecturer (2009), Humboldt Research Award (2013), Green Chemistry Minister of Education Award (2013), Green Chemistry Minister of Education Award (2013), Honorary Professor, Wuhan Institute of Technology (2013), TUM-IAS Honorary Hans Fischer Senior Fellow (2013), Honorary Professor, Wuhan University of Technology (2014), Association for the Advancement of Science(AAAS) Fellow (2015), Toray Science and Technology Prize (2016), Honorary Professor, Hebei Engineering University (2016), Negishi
Award (2018), Chemical Society of Japan Award (2019), The T.-Y. Luh Lectureship Award (2019).


All Rights Reserved by 2019 CCS International Conference on Green and Sustainable Chemistry