中国化学会第32届学术年会
重要日期
注册参加会议 登录会议管理
线上墙报
星状乳糖酰胺季铵盐表面活性剂的合成
石秀芳 张二壮 符峰 智丽飞*

分会

第三十五分会:胶体与界面化学

摘要

星状乳糖酰胺季铵盐表面活性剂的合成 石秀芳,张二壮,符峰,智丽飞* 太原科技大学化学与生物工程学院,山西太原,030024 *E-mail: lifeizhi@yeah.net 随着人们对产品的生物降解性,无毒和生物相容性的需求,糖基表面活性剂被广泛使用在洗涤剂、化妆品和个人护理等产品中,且在生物医学、制药和生物化学等方面有着潜在的应用前景。星状表面活性剂的结构接近于球形,结晶性小,溶解性能好,末端可导入一些功能性基团,容易根据不同目的对表面的官能团进行改性。把糖基引入季铵盐表面活性剂分子结构中,可能改善其刺激性,生物降解性,水溶性和配伍性等问题。星状乳糖酰胺季铵盐表面活性剂作为新型表面活性剂具有广阔的应用前景。 本文以乳糖酸、N,N-双(3-氨基丙基)十二烷基胺和溴代烷为原料,采用先胺酯反应,后季铵化两步法设计合成出系列星状乳糖酰胺季铵盐表面活性剂(N-十二烷基-N,N-双[(3-乳糖酰胺)丙基]-N-烷基溴化胺,CnDBLB,n=12,14,16)。利用红外光谱(IR)和核磁共振氢谱(1H-NMR)对产物结构进行了鉴定(图1),结果表示已经成功制备出星状乳糖酰胺季铵盐表面活性剂(CnDBLB),此合成方法具有制备工艺简捷、反应条件温和、选择性高等优点。 Fig. 1 1H-NMR chart of C12DBLB 关键词:乳糖酸;星状;表面活性剂 参考文献 [1]Yoshimura T., Kusano T., Iwase H.. Star-shaped trimeric quaternary mmonium bromide surfactants: adsorption and aggregation properties. Langmuir, 2012, 28, 9322-9331. [2]国外咨询.中国洗涤用品工业, 2017, 12, 98. [3]梁鹏龙,刘振东.糖基双子型表面活性剂合成的进展[J].日用化学工业,2005,35(4):232-236. 致 谢 国家自然科学基金(No. 22002105),山西省高等学校科技创新项目(No. 2020L0355),山西省自然科学基金(No. 201801D121051)资助。 Synthesis of Star-shaped Lactosamide Quaternary Ammonium Surfactant Xiufang Shi, Erzhuang Zhang, Feng Fu, Lifei Zhi* College of Chemistry and Biological Engineering, Taiyuan University of Science and Technology, Taiyuan, 030024 With people’s demand for product biodegradability, non-toxicity and biocompatibility, sugar-based surfactants are widely used in detergents, cosmetics and personal care products, and in biomedicine, pharmaceutical and biochemistry, etc. There are potential application prospects. The structure of the star-shaped surfactant is close to spherical, with low crystallinity and good solubility. Some functional groups can be introduced at the end, and it is easy to modify the functional groups on the surface according to different purposes. Introducing sugar groups into the molecular structure of quaternary ammonium salt surfactants may improve its irritation, biodegradability, water solubility and compatibility issues. Star-shaped lactosamide quaternary ammonium salt surfactant has broad application prospects as a new type of surfactant. In this paper, lactobionic acid, N, N-bis(3-aminopropyl) dodecylamine and bromoalkane are used as raw materials, and a series of star-shaped lactosamide quaternary quaternary products are designed and synthesized by a two-step method of amine ester reaction followed by quaternization. Ammonium salt surfactant (N-dodecyl-N, N-bis[(3-lactamide) propyl]-N-alkylamine bromide, CnDBLB, n=12,14,16). The structure of the product was identified by infrared spectroscopy (IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) (Fig. 1). The results indicate that the star-shaped lactosamide quaternary ammonium salt surfactant (CnDBLB) has been successfully prepared. This synthesis method it has the advantages of simple preparation process, mild reaction conditions and high selectivity. Keywords: lactobionic acid; star shape; surfactant

关键词

乳糖酸;星状;表面活性剂

线上墙报仅限年会已缴费参会代表观看。

您还没有登录,请您先 点击这里登录