范青华

男， 中国科学院化学研究所，国务院特殊津贴

专业领域

有机化学：不对称催化合成、生物活性杂环化合物、功能有机分子

学习/工作经历

1985.09-1989.07：湘潭大学化学系, 本科生
1989.09-1992.06：中国科学院化学研究所，硕士研究生
1995.02-1998.02：香港理工大学应用生物及化学科技系，博士研究生
1992.08-1998.03：中国科学院化学研究所，研究实习员、助理研究员
1998.04-2003.02：中国科学院化学研究所，副研究员
2003.03-至 今：中国科学院化学研究所，研究员
2012.04-至 今：中国科学院分子识别与功能重点实验室主任

学术成就和学术贡献简述

长期从事手性催化合成研究。围绕手性催化剂的选择性、催化效率和催化剂的分离回收等核心科学问题，突破传统负载手性催化剂的局限，率先提出并设计合成了以手性膦配体为核心的新型树状大分子负载催化剂，发现了明显的“树状分子效应”并揭示了其本质，建立了“均相催化，两相分离”催化剂分离回收新策略；提出了抗衡阴离子诱导的手性催化氢化新模式，实现了系列挑战性芳香杂环化合物的高效、高选择性催化氢化新反应，揭示了抗衡阴离子对反应选择性调控的本质与规律，为结构多样性手性氮杂环化合物的制备提供了绿色实用的新途径，相关反应被收入世界上最具权威性的有机化学工具书之一Organic Synthesis丛书，为手性合成化学领域的发展做出了重要贡献。在Chem. Rev., Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等期刊上发表SCI论文近200篇，合编/著学术专著3本；在国际国内做邀请学术报告70余次，部分工作获得国家自然科学二等奖（2005年，排名第二）。

化学公益贡献简述

积极推动手性化学研究领域的发展，参与创建了中国化学会手性化学专业委员会并担任秘书长，参与和组织了“手性中国”系列学术研讨会和中国化学会年会“手性化学”分会，并产生了积极影响。现任《化学进展》、《有机化学》、《化学通报》、《化学学报》、ACS Omega学术期刊编委；Asian Journal of Organic Chemistry, Molecular Diversity和ChemRxiv学术期刊国际顾问编委。曾任中国科学院大学化学学院副院长，积极推动国科大化学一流学科建设。
现任中国科学院化学研究所副所长（分管化学会工作）、中国化学会理事会常务理事并担任中国化学会秘书长，积极组织实施年度工作计划，落实常务理事会决议，积极推动化学会的发展。同时，为化学会秘书处和相关杂志编辑部的办公地点、人才队伍建设等方面提供大力支持。

代表性成果

1. Qing-Hua Fan,* Yan-Mei He, Fa-Ju Li, “Homogeneous Asymmetric Hydrogenation of Heteroaromatic Compounds Catalyzed by Transition Metal Complexes”, In Asymmetric Hydrogenation and Transfer Hydrogenation, Wiley-VCH GmbH, 2021, pp255-279.
2. Yan-Mei He, Yu Feng, Qing-Hua Fan*, “Asymmetric hydrogenation in the core of dendrimers”, Acc. Chem. Res. 2014, 47, 2894−2906.
3. Yan-Mei He, Feng-Tao Song, Qing-Hua Fan*, “Advances in transition metal-catalyzed asymmetric hydrogenation of heteroaromatic compounds”, Top. Curr. Chem. 2014, 343, 145–190.
4. Faju Li, Linhong Long, Yan-Mei He, Zeyu Li, Hui Chen,* Qing-Hua Fan*, “Manganese-catalyzed asymmetric formal hydroamination of allylic alcohols: a remarkable macrocyclic ligand effect”, Angew. Chem. Int. Ed. 2022, 61(26), e202202972.
5. Yu-Ping Tang, Yi-Er Luo, Jun-Feng Xiang, Yan-Mei He,* Qing-Hua Fan*, “Rhodium-catalyzed ON-OFF switchable hydrogenation using a molecular shuttle based on a [2]rotaxane with a phosphine ligand”, Angew. Chem. Int. Ed. 2022, 61(15), e202200638.
6. Ya Chen, Yan-Mei He, Shanshan Zhang, Tingting Miao, Qing-Hua Fan*, “Rapid construction of structurally diverse quinolizidines, indolizidines and their analogues via ruthenium-catalyzed asymmetric cascade hydrogenation/reductive amination”, Angew. Chem. Int. Ed. 2019, 58, 3809–3813.
7. Ya Chen, Yixiao Pan, Yan-Mei He,* and Qing-Hua Fan*, “Consecutive intermolecular reductive amination/asymmetric hydrogenation: facile access to sterically tunable chiral vicinal diamines and N-heterocyclic carbenes”, Angew. Chem. Int. Ed. 2019, 58, 16831–16834.
8. Tingting Miao, Zi-You Tian, Yan-Mei He, Fei Chen, Ya Chen, Zhi-Xiang Yu*, Qing-Hua Fan*, “Asymmetric hydrogenation of in situ generated isochromenylium intermediates by copper/ruthenium tandem catalysis”, Angew. Chem. Int. Ed. 2017, 56, 4135–4139.
9. Zhusheng Yang, Fei Chen,* Yan-Mei He, Nianfa Yang, Qing-Hua Fan*, “Highly enantioselective synthesis of indolines: Asymmetric hydrogenation at ambient temperature and pressure with cationic ruthenium diamine catalysts”, Angew. Chem. Int. Ed. 2016, 55, 13863–13866.
10. Wenpeng Ma, Jianwei Zhang, Cong Xu, Fei Chen, Yan-Mei He, Qing-Hua Fan*, “Highly enantioselective direct synthesis of endocyclic vicinal diamines by chiral Ru(diamine)-catalyzed hydrogenation of 2,2’-bisquinoline derivatives”, Angew. Chem. Int. Ed. 2016, 55, 12891–12894.
11. Zhiyong Zhao, Chun Chen, Yuanchen Dong, Zhongqiang Yang, Qing-Hua Fan,* Dongsheng Liu*, “Thermally triggered frame-guided assembly”, Angew. Chem. Int. Ed. 2014, 53, 13468–13470.
12. Jianwei Zhang, Fei Chen, Yan-Mei He, Qing-Hua Fan*, “Asymmetric ruthenium-catalyzed hydrogenation of 2,6-disubstituted 1,5-naphthyridines: Access to chiral 1,5-diaza-cis-decalins”, Angew. Chem. Int. Ed. 2015, 54, 4622–4625.
13. Guang-Hui Ouyang, Yan-Mei He, Yong Li, Jun-Feng Xiang, Qing-Hua Fan*, “Cation-triggered switchable asymmetric catalysis with chiral aza-CrownPhos”, Angew. Chem. Int. Ed. 2015, 54, 4334–4337.
14. Tianli Wang, Fei Chen, Jie Qin, Yan-Mei He, Qing-Hua Fan*, “Asymmetric ruthenium-catalyzed hydrogenation of 2- and 2,9-substituted 1,10-phenanthrolines”, Angew. Chem. Int. Ed. 2013, 52, 7172–7176.
15. Zi-Yuan Ding, Fei Chen, Jie Qin, Yan-Mei He, Qing-Hua Fan*, “Asymmetric hydrogenation of 2,4-disubstituted 1,5-benzodiazepines using cationic ruthenium diamine catalysts: an unusual achiral counteranion induced reversal of enantioselectivity”, Angew. Chem. Int. Ed. 2012, 51, 5706–5710.
16. Tianli Wang, Lian-Gang Zhuo, Zhiwei Li, Fei Chen, Ziyuan Ding, Yanmei He, Qing-Hua Fan,* Junfeng Xiang, Zhi-Xiang Yu, Albert S. C. Chan, “Highly enantioselective hydrogenation of quinolines using phosphine-free chiral cationic ruthenium catalysts: scope, mechanism, and origin of enantioselectivity”, J. Am. Chem. Soc. 2011, 133, 9878–9891.
17. Yu Feng, Zi-Tong Liu, Ji Liu, Yan-Mei He,* Qi-Yu Zheng, Qing-Hua Fan*, “Peripherally dimethyl isophthalate-functionalized poly(benzyl ether) dendrons: a new kind of unprecedented highly efficient organogelators”, J. Am. Chem. Soc. 2009, 131, 7950–7951.
18. Weijun Tang, Lijin Xu,* Qing-Hua Fan,* Jun Wang, Baomin Fan, Zhongyuan Zhou, Kim-hung Lam, Albert S. C. Chan*, “Asymmetric hydrogenation of quinoxalines with diphosphinite ligands: a practical synthesis of enantioenriched substituted tetrahydroquinoxalines”, Angew. Chem. Int. Ed. 2009, 48, 9135-9238.
19. Haifeng Zhou, Zhiwei Li, Zhijian Wang, Tianli Wang, Lijin Xu, Yanmei He, Qing-Hua Fan,* Jie Pan, Lianquan Gu, Albert S. C. Chan*, “Hydrogenation of quinolines using a recyclable phosphine-free chiral cationic ruthenium catalyst: Enhancement of catalyst stability and selectivity in an ionic liquid”, Angew. Chem. Int. Ed. 2008, 47, 8464-8467.
20. 丁奎岭，范青华 主编，《不对称催化新概念与新方法》，化学工业出版社，2009年2月。

代表性奖励荣誉情况

1. 2003年获国家杰出青年基金
2. 2005年国家自然科学二等奖（排名第二）
3. 2009年获“国务院政府特殊津贴”
4. 2013年入选国家百千万人才工程
5. 2015年基金委创新群体负责人

*以上信息由会士个人更新和维护。