巢晖

男， 暨南大学化学与材料学院

专业领域

化学生物学、无机化学

学习/工作经历

学士（1988-1992）：湘潭师范学院（现湖南科技大学）化学系
硕士（1994-1997）：南开大学化学学院
博士（1997-2000）：中山大学化学与化学工程学院
访问学者 (2000-2003)：香港科技大学化学系
博士后（2004-2005）：美国Texas A&M大学化学系
讲师（2000-2002）：中山大学化学与化学工程学院
副教授（2002-2007）：中山大学化学与化学工程学院
教授（2007-2016）：中山大学化学与化学工程学院
教授（2016-2025）：中山大学化学学院
教授（2026-至今）：暨南大学化学与材料学院

学术成就和学术贡献简述

从事生物无机化学研究，在探索光活化金属配合物抗肿瘤方面做出了突出贡献。包括通过金属配合物的超分子组装、氧化聚合和光物理性质调控，构建新型金属双光子光敏剂；利用金属配合物对线粒体代谢过程干预，诱导癌细胞内关键蛋白氧化损伤，揭示了乏氧条件下引起氧化还原失衡而导致肿瘤细胞死亡的新机制；研发出完全不依赖于氧气的新型金属光敏剂，在双光子激发下产生碳自由基，损伤线粒体最终诱导乏氧肿瘤细胞死亡；发现多个能有效克服肿瘤耐药和诱导免疫原性细胞死亡的金属配合物。以第一作者或通讯作者在Nature Chem、Nat Commun、PNAS、JACS、ACIE、Adv Mater等国际著名期刊发表SCI论文228篇，论文引用17700多次，H-index 72；申请中国发明专利22件，授权15件；参编专著教材8部。入选爱思维尔中国高被引学者和World Top 2% Scientists（斯坦福大学排名）。国家杰出青年科学基金获得者（2015），入选教育部新世纪优秀人才支持计划（2006）和广东特支计划百千万工程领军人才（2015）。

化学公益贡献简述

从教25年一直工作在化学教育第一线，长期承担多门本科生化学专业课的讲授。担任中山大学拔尖班导师，指导多名本科生先后获得8项国家大学生创新训练计划项目资助。曾担任广东实验中学“钟南山科学人才培养班”校外导师，积极参与中学生课外化学兴趣小组的指导。2011年被评为中山大学校级教学名师，2012年被评为广东省南粤优秀教师，2014年获宝钢优秀教师奖。担任中国化学会化学生物学专业委员会委员、广东省化学会常务理事和广东省化学会化学生物学专业委员会主任委员。积极参与国内外学术交流，先后参与承办多个国际、国内学术会议，并应邀多次在国内外学术会议做大会报告或邀请报告。和欧美高校多个课题组开展了广泛而富有成效的科研合作，包括法国巴黎文理研究大学Gilles Gasser教授、英国华威大学Peter J. Sadler教授、美国犹他大学Peter J. Stang教授等。2022年参与由 Peter J. Sadler 教授领衔的In-cell Organometallic Redox Catalysis团 队，获得了英国皇家化学会的 Dalton Division Horizon Prize。

代表性成果

1. Huaiyi Huang†, Samya Banerjee† (†equal contributors), Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser*, Hui Chao*, Peter J. Sadler*, “Targeted photoredox catalysis in cancer cells”, Nat. Chem., 11 (2019) 1041-1048.
2. Johannes Karges, Shi Kuang, Federica Maschietto, Olivier Blacque, Ilaria Ciofini, Hui Chao*, Gilles Gasser*, “Rationally Designed Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy”, Nat. Commun., 11 (2020) 3262.
3. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Juanjuan Huang, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for two-photon photodynamic therapy”, Proc. Natl, Acad. Sci. USA, 116 (2019) 20296-20302.
4. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”, Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
5. Xianbo Wu, Jinzhe Liang, Jun Shu, Zeqi Li, Tiantian Yin, Xiting Zhang*, Hui Chao*, “Narrow-Bandgap Iridium(III)-C3N5 Nanocomplex as Oxygen Self-Sufficient Piezo-Sonosensitizers for Hypoxic Tumor Sonodynamic Immunotherapy“, J. Am. Chem. Soc., 147 (2025) 15329-15343.
6. Ling Wang†, Lingtan Kong†, Ding-Qi Zhang† (†equal contributors), Liuqi Ye, Sang-cuo Nao, Daniel Shiu-Hin Chan, Xueying Li, Yutong Peng, Lijun Yang, Chun-Yuen Wong, Vincent Kam Wai Wong*, Wanhe Wang*, Hui Chao*, Chung-Hang Leung*, “Inhibiting glycolysis and disrupting the mitochondrial HK2-VDAC1 protein-protein interaction using a bifunctional lonidamine-conjugated metal probe for combating triple-negative breast cancer”, J. Am. Chem. Soc., 147 (2025) 14824-14836).
7. Shi Kuang†, Fangmian Wei† (†equal contributors), Johannes Karges, Libing Ke, Kai Xiong, Xinxing Liao, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Photo-Decaging of A Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia”, J. Am. Chem. Soc., 144 (2022) 4091−4101.
8. Ying Zhou†, Kai Xiong† (†equal contributors), Tao Feng, Xianbo Wu, Jinzhe Liang*, Yu Chen*, Hui Chao*, “A Nucleus-Targeting Ruthenium(II) Complex Induces DNA Condensation in Cisplatin-Resistant Tumor Cells”, Angew. Chem. Int. Ed., 64 (2025) e202504970.
9. Jinrong Yang, Fa Wang, Shuqi Huang, Tao Feng, Kai Xiong, Yu Chen*, Hui Chao*, “A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno- and Chemo-Immunotherapy in Cisplatin-Resistant Tumor Cells”, Angew. Chem. Int. Ed., 64 (2025) e202505689.
10. Tao Feng, Zixin Tang, Jun Shu, Xianbo Wu, Hui Jiang, Zhuoli Chen, Yu Chen, Liangnian Ji, Hui Chao*, “A Cyclometalated Ruthenium(II) Complex Induces Oncosis for Synergistic Activation of Innate and Adaptive Immunity”, Angew. Chem. Int. Ed., 63 (2024) e202405679.
11. Shi Kuang, Biyue Zhu, Jing Zhang, Fan Yang, Bo Wu, Weihua Ding, Liuyue Yang, Shiqian Shen, Seven H Liang, Prasenjit Mondal, Mohanraja Kumar, Rudolph E. Tanzi, Can Zhang, Hui Chao*, Chongzhao Ran*, “A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Treatment of Alzheimer's Disease”, Angew. Chem. Int. Ed., 62 (2023) e202312519.
12. Asma Mani†, Tao Feng†, Albert Gandioso†, Robin Vinck† (†equal contributors), Anna Notaro, Lisa Gourdon, Pierre Burckel, Bruno Saubaméa, Olivier Blacque, Kevin Cariou, Jamel-Eddine Belgaied, Hui Chao,* Gilles Gasser,* “Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared”, Angew. Chem. Int. Ed., 62 (2023) e202218347.
13. Kai Xiong†, Cheng Ouyang† (†equal contributors), Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Chiral RuII-PtII Complexes Inducing Telomere Dysfunction against Cisplatin-Resistant Cancer Cells”, Angew. Chem. Int. Ed., 61 (2022) e202204866.
14. Libing Ke†, Fangmian Wei† (†equal contributors), Lina Xie, Johannes Karges, Yu Chen, Liangnian Ji, Hui Chao*, “A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two-Photon Photodynamic Therapy using an Apoptosis-Ferroptosis Hybrid Pathway”, Angew. Chem. Int. Ed., 61 (2022) e202205429. (Hot Paper)
15. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao*, Ye Zhang*, “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking”, Angew. Chem. Int. Ed., 60 (2021) 7597-7601.
16. Lili Wang, Ruilin Guan, Lina Xie, Xinxing Liao, Kai Xiong, Thomas W. Rees, Yu Chen, Liangnian Ji, Hui Chao*, “An ER-Targeting Iridium(III) Complex which Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer”, Angew. Chem. Int. Ed., 60 (2021) 4657-4665. (VIP Article)
17. Cheng Ouyang, Yongguang Li, Thomas W. Rees, Xinxing Liao, Jianhua Jia, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “Supramolecular Assembly of An Organoplatinum(II) Complex with Ratiometric Dual Emission for Two-Photon Bioimaging”, Angew. Chem. Int. Ed., 60 (2021) 4150-4157.
18. Shi Kuang†, Lingli Sun† (†equal contributors), Xianrui Zhang, XinXing Liao, Thomas W. Rees, Leli Zeng, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals against Hypoxic Tumors”, Angew. Chem. Int. Ed., 59 (2020) 20697-20703.
19. Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W. Rees, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II”, Angew. Chem. Int. Ed., 59 (2020) 16631-16637. (Hot Paper)
20. Chengzhi Jin†, Fengyin Liang† (†equal contributors), Jinquan Wang, Lili Wang, Jiangping Liu, Xinxing Liao, Thomas W. Rees, Bo Yuan, Hui Wang, Yong Shen*, Zhong Pei*, Liangnian Ji, Hui Chao*, “Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging”, Angew. Chem. Int. Ed., 59 (2020) 15987-15991. (Hot Paper)
21. Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W. Rees, Ruilin Guan, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, “FerriIridium: A Lysosome-Targeting Iridium(III) Prodrug for Iron(III)-Activated Chemotherapy in Gastric Cancer Cells”, Angew. Chem. Int. Ed., 59 (2020) 3315-3321. (VIP Article)
22. Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao*, Gilles Gasser*, “Polymeric encapsulation of novel homoleptic bis(dipyrrinato) zinc(II) complexes with long lifetimes for applications as photodynamic therapy photosensitisers”, Angew. Chem. Int Ed., 58 (2019) 14334-14340.
23. Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells", Angew. Chem. Int. Ed., 56 (2017) 14898-14902. (VIP Article, Inside front cover)
24. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”, Angew. Chem. Int. Ed., 54 (2015) 14049-14052. (VIP Article)
25. Jia Li, Leli Zeng*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*, “Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers”, Adv. Mater., 34 (2022) 2100245.

代表性奖励荣誉情况

1. 巢晖，青年化学奖，2005年，中国化学会。
2. 巢晖，校级教学名师，2011年，中山大学。
3. 毛宗万、巢晖、计亮年、刘建忠、鲁统部、刘杰、高峰、陈小明、郑康成、黄锦汪，金属酶模型化合物的结构、生物功能和作用机制研究，广东省科学技术奖一等奖，2011年，广东省人民政府。
4. 毛宗万、计亮年、巢晖、刘建忠、鲁统部，金属酶的化学模拟及其构效关系研究，国家自然科学奖二等奖，2012年，中华人民共和国国务院。
5. 巢晖，南粤优秀教师，2012年，中共广东省教育工作委员会等。
6. 巢晖，宝钢优秀教师奖，2014年，宝钢教育基金会。
7. 巢晖，乔正平，石建新，陈小明，龚孟濂，建设国家精品课程，培养化学创新人才，第七届广东教育教学成果奖（高等教育）一等奖，2014年, 广东省教育厅。
8. 毛宗万，童叶翔，陈小明，巢晖，陈六平，乔正平，闫素君，汪波，李攻科，卢锡洪，李高仁，姜隆，刘鹏， 新时期化学创新人才培养模式的探索与实践， 高等教育国家级教学成果奖二等奖，2018，中华人民共和国教育部。
9. Samya Banerjee, Olivier Blacque, Hui Chao, Guy J. Clarkson, James P. C. Coverdale, Robert J. Deeth, Gilles Gasser, Abraha Habtemariam, Huaiyi Huang, Thomas Malcomson, Martin J. Paterson, Ivan Prokes, Kangqiang Qiu, Isolda Romero-Canelón, Peter J. Sadler, Carlos Sanchez-Cano, Volker Schünemann, Joan Josep Soldevila-Barreda, Lijiang Song, Michael Staniforth, Vasilios Stavros, Martin Wills, Juliusz A. Wolny, Pingyu Zhang, In-cell Organometallic Redox Catalysis, RSC Dalton Division Horizon Prize，2022年，英国皇家化学会。
10. 巢晖、毛宗万、谭彩萍、夏炜、徐亮、陈禹、曹乾、刘文婷，芙兰奖，2024年，中山大学

*以上信息由会士个人更新和维护。