黄飞鹤

男， 浙江大学

专业领域

超分子化学

学习/工作经历

09/1992-07/1996: 合肥工业大学化工学院，高分子材料与工程学士。
09/1996-07/1999: 中国科学技术大学高分子科学与工程系, 高分子化学与物理硕士。导师：何平笙教授和阮德礼教授。
09/1999-07/2000: University of Washington化学系，研究生学习。
08/2000-08/2003: Virginia Polytechnic Institute & State University化学系，化学理学硕士；导师：Harry W. Gibson教授。
08/2003-03/2005: Virginia Polytechnic Institute & State University化学系，化学理学博士；导师：Harry W. Gibson教授。

学术成就和学术贡献简述

针对超分子聚合物研究中主客体识别构筑基元有限、结构多层次控制困难、多重响应性超分子聚合物稀缺等瓶颈问题，开展了基于主客体识别构筑超分子聚合物的系统研究。建立了21-冠-7/二级铵盐和柱[5]芳烃/烷基链两种新的主客体识别构筑基元，基于主客体识别的高度选择性发展了超分子聚合物结构多层次控制的新方法，基于主客体识别丰富的环境响应性开拓了构筑多重响应性超分子聚合物的新策略。建立的两种新的主客体识别基元已被40个国家221个课题组广泛应用于各类超分子体系的构筑，发表论文达479篇。主要奖励荣誉：国家杰出青年基金获得者、长江学者特聘教授、国家万人计划领军人才、中国化学会-阿克苏诺贝尔化学奖、德国Bruno Werdelmann Lectureship Award、英国皇家化学会Cram Lehn Pedersen Prize in Supramolecular Chemistry、英国皇家化学会Polymer Chemistry Lectureship Award、浙江省自然科学奖一等奖（第一完成人）。任国务院学位委员会学科评议组成员、中国化学会超分子化学专业委员会副主任委员、JACS顾问编委。

化学公益贡献简述

现任国务院学位委员会化学学科评议组成员、中国化学会高分子学科委员会委员、中国化学会超分子化学专业委员会副主任委员、中国化学会晶体化学专业委员会委员、中国化学会分子聚集发光专业委员会委员、中国化学会分子医学专业委员会委员、中国化学会奖励推荐委员会委员、非共价相互作用国际会议国际顾问委员会委员、浙江省化学会理事，积极推动化学学科发展、化学知识传播、中国化学会的发展。应邀在国内外作学术报告240次，包括应邀到澳大利亚全国高分子会议上作学术报告，应邀在全国有机化学学术讨论会上作大会报告，应邀到第15届亚洲化学大会上作Asian Rising Stars分会邀请报告，应邀到韩国全国高分子会议上作学术报告，应邀在全国大环化学暨超分子化学学术讨论会上作大会报告，应邀在美国举行的第一届人工分子开关与马达高登会议（Gordon Research Conference）上作邀请报告，应邀在法国举行的第十届大环与超分子化学国际研讨会（ISMSC-10）上作大会报告，应邀在澳大利亚举行的第23届IUPAC国际物理有机化学会议上作大会报告，应邀在葡萄牙里斯本举行的第一届非共价相互作用国际会议上作大会报告，积极加强国内外化学学术交流。

代表性成果

已发表论文435篇，如下为2024年以来发表的论文：
366. Yao, Y.; Zhang, P.; Zhou, D.; Lai, Z.; Li, S.; Huang, F.*; Zhang, Z*. A meso-molecular muscle based on copillar[5]arenes. Chin. Chem. Lett. 2024, 35, 108712.
367. Han, Y.; Xie, Y.; Zhang, J.; Tan, S.; Zhang, H.;* Tang, B.;* Sessler, J.;* Huang, F.* Fjord-Type AIEgens Based on Inherent Through-Space Conjugation. CCS Chem. 2024, 6, 1739–1747.
368. Chen, L.;# You, W.;# Wang, J.; Yang, X.; Xiao, D.; Zhu, H.; Zhang, Y.; Li, G.;* Yu, W.;* Sessler, J. L.;* Huang, F.* Enhancing the Toughness and Strength of Polymers Using Mechanically Interlocked Hydrogen Bonds. J. Am. Chem. Soc. 2024, 146, 1109-1121.
369. Liu, Y.; Wang, L; Zhao, L.; Zhang, Y.;* Li, Z.;* Huang, F.* Multiple hydrogen bonding driven supramolecular architectures and their biomedical applications. Chem. Soc. Rev., 2024, 53, 1592-1623.
370. Wang, L.; Xiong, Z.; Sun, J.; Huang, F.; Zhang, H.*; Tang, B.*. How the Length of Through-Space Conjugation Influences the Clusteroluminescence of Oligo(Phenylene Methylene)s. Angew. Chem. Int. Ed. 2024, 63, e202318245.
371. Li M.; Shao, L.; Liu, Z.; Liu, R.; Stoikov, I. I.; Khashab, N. M.; Hua, B.;* Huang, F.* Cis–Trans and Length-Selective Molecular Discrimination of Halogenated Organic Compounds by a Crystalline Hybrid Macrocyclic Arene. ACS Appl. Mater. Interf. 2024, 16, 6614-6622.
372. Li, B.;# Li, Q.;# Qi, Z.; Li, Z.; Yan, X.; Chen, Y.; Xu, X.; Pan, Q.; Chen, Y.; Huang, F.;* Ping, Y.* Supramolecular Genome Editing: Targeted Delivery and EndogenousActivation of CRISPR/Cas9 by Dynamic Host-Guest Recognition. Angew. Chem. Int. Ed. 2024, 63, e202316323.
373. Yan, M.; Wu, S.; Wang, Y.; Liang, M.; Wang, M.; Hu, W.; Yu, G.;* Mao, Z.;* Huang, F.;* Zhou, J.* Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions. Adv. Mater. 2024, 36, 2304249.
374. Xu, D.; Li, Y.; Yin, S.* Huang, F.* Strategies to Address Key Challenges of Metallacycle/Metallacage-based Supramolecular Coordination Complexes in Biomedical Applications. Chem. Soc. Rev. 2024, 53. 3167-3204.
375. Shan, T.; Chen, L.; Xiao, D.; Xiao, X.; Wang, J.; Chen, X.; Guo, Q.; Li, G.;* Stoddart, J. F.;* Huang, F.* Adaptisorption of Nonporous Polymer Crystals. Angew. Chem. Int. Ed. 2024, 136, e202317947.
376. Yang, K.; Bai, B.; Huang, F.;* Yu, G.* Drug-Initiated Poly(thiocitc acid) Polymer Incorporating Host-Guest Interaction for Cancer Combination Chemotherapy. iScience, 2024, 27, 109070.
377. Yang, K.; Bai, B.; Lei, J.; Yu, X.; Qi, S.; Wang, Y.; Huang, F.; Tong, Z.; Yu, G.* Biodegradable Lipid-Modified Poly(Guanidine Thioctic Acid)s: A Fortifier of Lipid Nanoparticles to Promote the Efficacy and Safety of mRNA Cancer Vaccines. J. Am. Chem. Soc. 2024, 146, 11679-11693.
378. Hu, W.; Ye, B.; Yu, G.; Yang, H.; Wu, H.; Ding, Y.; Huang, F.; Wang, W.*; Mao, Z.*. Dual-Responsive Supramolecular Polymeric Nanomedicine for Self-Cascade Amplified Cancer Immunotherapy. Adv. Sci. 2024, 11. 2305382.
379. Liu, Z.; Li, M.;* Fang, S.; Shao, L.;* Hua, B.;* Huang, F.* Highly selective separation of toluene/methylcyclohexane based on pagoda[5]arene nonporous adaptive crystals. Org. Chem. Front., 2024, 11, 2756-2761.
380. Sheng, X.;# Wang, Z.;# Sheng, G.;# Zhu, C.; Xiao, D.; Shan, T.; Xiao, X.; Liu, M.; Li, G.;* Zhu, Y.;* Sessler, J. L.;* Huang, F.* Three-Dimensional Crystalline Organic Framework Stabilized by Molecular Mortise-and-Tenon Jointing. J. Am. Chem. Soc. 2024, 146, 12547-12555.
381. Li, Y.; Huang, F.;* Stang, P. J.;* Yin, S.* Supramolecular Coordination Complexes for Synergistic Cancer Therapy. Acc. Chem. Res. 2024, 57, 1174-1187.
382. He, L.; Jiang, Y.; Wei, J.; Zhang, Z.; Hong, T.; Ren, Z.; Huang, J.;* Huang, F.;* Stang, P. J.;* Li, S.* Highly robust supramolecular polymer networks crosslinked by a tiny amount of metallacycles. Nat. Commun. 2024, 15, 3050.
383. Nazarova, A.;* Mostovaya, O.; Bukharov, M.; Nagaeva, A.; Yusupov, G.; Zelenikhin, P.; Hua, B.; Huang, F.; Padnya, P.; Stoikov, I.* Peptidomimetics based on pillar[5]arene: Charge effect on self-assembly, toxicity, and herbicide binding. Colloid Surf. A-Physicochem. Eng. Asp. 2024, 693, 134050.
384. Wang, J.; You, W.; Chen, L.; Xiao, D.; Xiao, X.; Shan, T.; Liu, Y.; Liu, M.; Li, G.;* Yu, W.;* Huang, F.* Adaptive and Robust Vitrimers Fabricated by Synergy of Traditional and Supramolecular Polymers. Angew. Chem. Int. Ed. 2024, 63, e202405761.
385. Xiao, X.; Xu, D.; Han, H.; Wang, D.; Lei, S.; Liu, R.; Hu, N;* Sessler, J.;* Huang, F.* Sensitive Intracellular Recording of Action Potentials by Supramolecular Self-Assembled Electrodes. Adv. Funct. Mater. 2024, 202404634.
386. Fan, G.; Zhang, Z.; Wang, G.; Shao, L.; Hua, B.;* Huang, F.* Construction of hydrocarbon belts based on macrocyclic arenes. Chem. Sci. 2024, 15, 10713-10723.
387. Zhang, Y.; Liu, Y.; Wu, Y.; Ge, C.; Li, B.; Wei, Y.; Qian, Y.; Li, Q.;* Huang, F.;* Li, H.* A Tetracationic Cyclophane. CCS Chem. 2024, 6, DOI:10.31635/ccschem.024.202404345.
388. Ye, B.; Hu, W.;* Yu, G.; Yang, H.; Gao, B.; Ji, J.; Mao, Z.;* Huang, F.; Wang, W.;* Ding, Y.* A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy. ACS Nano 2024, 18, 16967-16981.
389. Wang, Y.;* Huang, F.* Highly site-selective C(sp3)–H bond functionalization enabled by framework confinements. Chem Catalysis 2024, 4, DOI: 10.1016/j.checat.2024.100961.
390. Liu, X.; Liu, X.; Zheng, H.; Lu, K.; Chen, D.; Xiong, C.; Huang, F.; Zhang, L.;* Zhang, D.* Improvement of hydrophilicity and formation of heparin/chitosan coating inhibits stone formation in ureteral stents. Colloid Surf. A-Physicochem. Eng. Asp. 2024, 694.
391. Xiao, M.; Liu, Z.; Liu, P.; Fang, S.; Shao, L.; Hua, B.;* Liu, Y.;* Huang, F.* A Pillararene-Based Cavitand: Synthesis and Solid-State Capsular Assemblies Induced by Linear Alkanes with Specific Lengths. Org. Lett. 2024, 26, 6220-6224.
392. Xiao, D.;# Jin, Z.;# Sheng, G.;# Chen, L.; Xiao, X.; Shan, T.; Wang, J.; Navik, R.; Xu, J.; Zhou, L.; Guo, Q.-H.; Li, G.;* Zhu, Y.;* Stoddart, J. F.;* Huang, F.* Single crystals of purely organic free-standing two-dimensional woven polymer networks. Nat. Chem. 2024, 16, 1906-1914.
393. Li, Y.; Li, S.; Wang, M.; Shao, L.; Fang, S.;* Hua, B.;* Huang, F.* Two pyrene-based cagearene constitutional isomers: synthesis, separation, and host–guest chemistry. Org. Chem. Front. 2024, 11, 4992-4996.
394. Wang, Y.; Zhang, J.; Xu, Q.; Tu, W.; Wang, L.; Xie, Y.; Sun, J.; Huang, F.; Zhang, H.;* Tang, B.* Narrowband clusteroluminescence with 100% quantum yield enabled by through-space conjugation of asymmetric conformation. Nat. Commun. 2024, 15, 6426.
395. Wang, Z.;# Wu, Y.;# Zhang, Z.; Sheng, X.; Fang, S.; Liu, Y.; Gong, Y.; Wang, M.; Song, N.;* Huang, F.* A Pillar[5]arene-Containing Metal-Organic Framework for Rapid and Highly-Capable Adsorption of a Mustard Gas Stimulant. J. Am. Chem. Soc. 2024, 146, 23330-23337.
396. He, L.; Wei, J.; Zhang, Z.; Shentu, N.; Wang, J.; Yu, J.; Ren, Z.; Liu, J.; Li, G.; Huang, F.; Li, S.* Improvement of Polymer Mechanical Behaviors by Introducing [2]Rotaxane Units with Intra- and Intermolecular Hydrogen Bonds. Macromolecules 2024, 57, 7777-7786.
397. Li, M.; Yang, Y.; Liu, R.; Wang, Y.; Shao, L.; Hua, B.;* Liu, X.;* Huang, F.* Pillar[5]arene-Based Ion-Pair Recognition for Encapsulation of a Stilbazolium-Type Dye with Enhanced Photophysical Properties and Nonlinear Optical Activity. Chem.-Eur. J. 2024, 30, e202402345.
398. Chen, L.; Tan, M.; Jin, J.; Zhang, Z.; Huang, F.; Li, S.;* Li, Y.* Synthesis and Application of Chiral Organic Imine Molecular Cages. Chin. J. Org. Chem. 2024, 44, 2617-2639.
399. Zhu, W.;#,* Zhao, B.;# Zhu, H.;* Huang, F.* Anthracene-containing crown ether: synthesis, host–guest properties and modulation of solid-state luminescence. Chem. Sci. 2024, 15, 16300-16306.
400. Xu, J.; Wang, T.; Deng, S.; Lai, W.; Shi, Y.; Zhao, Y.; Huang, F.;* Wei, P.* Visible Light-Responsive Crystalline B←N Host Adducts with Solvent-Induced Allosteric Effect for Guest Release. Angew. Chem. Int. Ed. 2024, 63, DOI: 10.1002/anie.202411880.
401. Chen, L.;# Liu, Y.;# You, W.;# Wang, J.; He, Z.; Mei, H.; Yang, X.; Yu, W.; Li, G.;* Huang, F.* Construction of Slide-Ring Polymers Based on Pillar[5]arene/Alkyl Chain Host-Guest Interactions Angew. Chem. Int. Ed. 2024, 63, e202417713.
402. Liu, T.;# Zhu, L.;# Liu, K.; Liu, Z.; Liu, Y.; Zhang, Y.; Hu, Y.;* Guo, Q.;* Huang, F.* Diameter-Controlled Synthesis of Carbon Nanotubes Using [2n]Collarenes as Rigid Organic Templates. J. Am. Chem. Soc. 2024, 146, 32445-32451.
403. Shurpik, D. N.;* Aleksandrova, Y. I.; Makhmutova, L. I.; Akhmedov, A. A.; Nazarova, A. A.; Lodochnikova, O. A.; Ivshin, K.; Kataeva, O. N.; Islamov, D. R.; Huang, F.; Stoikov, I. I.* Supramolecular Self-Assembly of Monosubstituted Pillar[5]Arenes Under the Control of the Nature of the Amide Moiety. ChemistrySelect. 2025, 10, e202405414.
404. He, L.; Wei, J.; Ren, Z.; Li, Y.; Zhang, Z.;* Li, G.; Huang, F.; Li, S.* Polyurethane Elastomers Strengthened by Pseudo[1]rotaxanes Based on Pillararenes. Angew. Chem. Int. Ed. 2025, 64, e202421557.
405. Wang, Z.;# Zhao, L.;# Zhang, Z.;# Sheng, X.; Yue, H.; Liu, R.; Liu, Z.; Li, Y.; Shao, L.; Peng, Y.;* Hua, B.;* Huang, F.* Superhydrophobic and Self-Healing Porous Organic Macrocycle Crystals for Methane Purification under Humid Conditions. J. Am. Chem. Soc. 2025, 147, 5, 4210–4218.
406. Wu, Y.; Tang, M.; Barsoum, M. L.; Chen, Z.;* Huang, F.* Functional crystalline porous framework materials based on supramolecular macrocycles. Chem. Soc. Rev., 2025, 54, 2906–2947.
407. Xu, Z.; Ying, X.; Li, Y.; Dong, X.; Liu, J.; Wang, S.; Little, M. A.; Zhang, D.; Xie, Y.; Zhang, Z.; Yu, L.; Huang, F.; Li, S.* Template-directed self-assembly of porphyrin nanorings through an imine condensation reaction. Chem. Sci., 2025, 16, 5166–5173.
408. Wu, Y.;# Shi, L.;# Xu, L.;# Ying, J.; Miao, X.; Hua, B.;* Chen, Z.;* Sessler, J. L.;* Huang, F.* Supramolecular docking structure determination of alkyl-bearing molecules. Nature 2025, 640, 676–682.

代表性奖励荣誉情况

黄飞鹤；国务院政府特殊津贴专家；2023
黄飞鹤；中国化学会会士；2023
黄飞鹤、汪峰、颜徐州、吉晓帆、董盛谊; 浙江省自然科学奖一等奖；2020、浙江省人民政府
黄飞鹤；竺可桢学院年度最佳专业导师；2020、浙江大学
黄飞鹤；浙江大学第六届师德先进个人；2019、浙江大学
黄飞鹤；Newton Advanced Fellowship；2018、英国皇家学会
黄飞鹤； Polymer Chemistry Lectureship Award；2016、英国皇家化学会
黄飞鹤； Cram Lehn Pedersen Prize in Supramolecular Chemistry；2015、英国皇家化学会
黄飞鹤；中国化学会-阿克苏诺贝尔化学奖；2014、中国化学会

*以上信息由会士个人更新和维护。