李昂

男， 中国科学院上海有机化学研究所，杰青/万人领军

专业领域

复杂天然产物的化学合成；天然产物的作用机制解析

学习/工作经历

2000.09--2004.07 北京大学化学与分子工程学院化学专业本科学生
2004.07--2010.01 美国斯克里普斯研究所生物学博士研究生
2010.01--2010.09 新加坡化学与工程科学研究所博士后
2010.09--至今 中国科学院上海有机化学研究所研究员、课题组长
2019.09--至今 中国科学院上海有机化学研究所副所长
2025.01--至今 中国科学院上海有机化学研究所党委副书记

学术成就和学术贡献简述

天然产物合成领域取得了具有国际影响力的研究成果。发展了针对拥挤环系的电环化/芳构化、普林斯环化等特色鲜明的合成策略，结合先进的合成方法，完成了14类天然产物的全合成，对其未知生物学功能和相应作用机制进行了探索。主要学术创新点包括：（1）对于复杂分子结构的深刻解读，善于利用几何对称性、拓扑相似性、生源关联性等天然产物结构中的隐含要素，提出具有启发性的合成思路，将全合成化繁为简；（2）对于特定核心结构的新颖合成策略，例如打破分步修饰苯环的常规思路，发展电环化/芳构化策略，从头构建天然产物结构中的多取代苯环；（3）对于先进合成方法的发展和运用，一方面将碳氢键官能化等新反应融入复杂分子的构建之中，另一方面深入挖掘普林斯环化等未被全合成界充分重视的古老反应的潜力，既提升了目标分子合成的效率，又丰富了相关合成方法学的内容。代表性研究成果包括：（1）虎皮楠生物碱的全合成；（2）电环化/芳构化策略的发展和应用；（3）普林斯环化策略的发展和应用。

化学公益贡献简述

发展了针对拥挤环系的电环化/芳构化、普林斯环化等特色鲜明的合成策略。

代表性成果

1.L. Ren, Z. Lu, D. Wu, M. Ma, and A. Li,* Total synthesis of paxdaphnine A and daphlongamine B via an aza-prins cyclization strategy, J. Am. Chem. Soc. 2025, 147, 27137−27142.
2.J. Li, P. Ren, L. Wang, Y. Zhang, P. Yang,* W. He,* and A. Li,* Inverse-electron-demand Diels–Alder approach to densely substituted bicyclo[3.2.2]nonanes: Discovery of an autophagy regulator, Chin. Chem. Lett. DOI:10.1016/j.cclet.2025111381.
3.Y. Fei, B. Fan, Z. Liu, M. Ba, Z. Cui, P. Yang,* A. Li,* Concise total synthesis of ambiguine P. J. Am. Chem. Soc. 2025, 147, 18391−18396.
4.Y. Wu, S. Wang, Z. Guo, M. Sun, Z. Xu, Y. Du, F. Zhu, Y. Su, Z. Xu, Y. Xu, X. Gong, R. Fang, J. Hu, Y. Peng, Z. Ding, C. Liu, A. Li,* W. He,* Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy, Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2400809121.
5.M. Ba, F. He, L. Ren, W. G. Whittingham, P. Yang, A. Li,* Scalable total synthesis of acremolactone B, Angew. Chem. Int. Ed. 2024, 63, e202314800.
6.Y. Peng, Y. Zhang, R. Fang, H. Jiang, G. Lan, Z. Xu, Y. Liu, Z. Nie, L. Ren, F. Wang, S.-D. Zhang, Y. Ma, P. Yang, H.-H. Ge, W.-D. Zhang,* C. Luo,* A. Li,* W. He,* Target identification and mechanistic characterization of indole terpenoid mimics: proper spindle microtubule assembly is essential for Cdh1-mediated proteolysis of CENP-A, Adv. Sci. 2024, 11, 2305593.
7.W. Zhang, M. Lu, L. Ren, X. Zhang, S. Liu, M. Ba, P. Yang, A. Li,* Total synthesis of four classes of Daphniphyllum alkaloids, J. Am. Chem. Soc. 2023, 145, 26569–26579.
8.B.-C. Yan, M. Zhou, J. Li, X.-N. Li, S.-J. He, J.-P. Zuo, H.-D. Sun, A. Li,* P.-T. Puno,* (–)-Isoscopariusin A, a naturally occurring immunosuppressive meroditerpenoid: structure elucidation and scalable chemical synthesis. Angew. Chem. Int. Ed. 2021, 60, 12859–12867.
9.P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,* A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 2020, 142, 13701–13708.
10.S. Zhou, K. Xia, X. Leng, A. Li,* Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc. 2019, 141, 13718–13723.
11.X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed. 2019, 58, 6053–6058.
12.Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc. 2018, 140, 9211–9218.
13.S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc. 2018, 140, 9025–9029.
14.W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 2018, 140, 4227–4231.
15.Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 2018, 57, 952–956.
16.J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc. 2017, 139, 14893‒14896.
17.Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 2017, 139, 5558–5567.
18.H. Li, Q. Chen, Z. Lu, A. Li,* Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc. 2016, 138, 15555–15558.
19.P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 2016, 55, 6964–6968.
20.Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 2016, 138, 3982–3985.
21.M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole. Angew. Chem. Int. Ed. 2016, 55, 2851–2855.
22.Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc. 2015, 137, 13764–13767.
23.S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,* Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed. 2015, 54, 6878–6882.
24.M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun. 2015, 6, 6445.
25.Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun. 2015, 6, 6096.
26.J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 2014, 136, 16477–16480.
27.Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed. 2014, 53, 13840–13844.
28.Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed. 2014, 53, 9012–9016.
29.J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 2014, 136, 8185–8188.
30.Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed. 2013, 52, 9201–9204.
31.Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum alkaloid daphenylline. Nat. Chem. 2013, 5, 679–684.
32.M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc. 2012, 134, 8078–8081.
33.J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 2012, 134, 920–923.

代表性奖励荣誉情况

2026 American Chemical Society Arthur C. Cope Scholars Award
2022 China Youth Science and Technology Award
2022 Chinese Chemical Society−Royal Society of Chemistry Young Chemist Award
2020 XPLORER Prize
2020 Thieme−IUPAC Prize in Synthetic Organic Chemistry
2019 Fellow, Royal Society of Chemistry
2017 Tetrahedron Young Investigator Award for Organic Synthesis
2016 Chinese−American Chemistry and Chemical Biology Professors Association Distinguished Faculty Award
2016 ChemComm Emerging Investigator Lectureship
2015 WuXi PharmaTech Life Science and Chemistry Award

*以上信息由会士个人更新和维护。