甄宇红

女， 大连医科大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1988年-1992年， 华东理工大学，精细化工系化学制药专业，学士学位。
1992年-1994年， 河北省药物研究所，助理工程师。
1994年-1997年， 大连理工大学，化工学院精细化工专业，硕士学位。
1997年-现在，大连医科大学药学院，讲师、副教授、教授。
2003年-2008年，大连理工大学，环境与生命学院生物化工专业，博士学位。
2009年-2010年，日本金沢大学，药学部，访问学者。
2009年-2011年，大连赛姆生物技术公司，博士后。
2019年-2020年，美国加州大学圣芭芭拉分校，访问学者。

研究领域和兴趣

靶向药物递送

主要业绩

主要从事抗肿瘤药物研究，包括抗肿瘤基因载体的构建及递送研究、天然抗肿瘤活性物质的结构改造及活性研究。主持和参加国家级科研课题多项；发表论文70余篇，其中SCI收录40余篇；获得大连市科技进步奖3项，辽宁省科技进步奖2项；获授权发明专利2项。

代表成果

1. Litao Hu, Huiling Ma, Chunpeng Yang, Kang Wang, Xu Ji, Tingxue Xu, Hong Xu, Yinan Zhao*, Yuhong Zhen*. Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer. International Journal of Biological Macromolecules.2025,311:144083. D O I：10.1016/j.ijbiomac.2025.144083.
2. Chunpeng Yang, Huiling Ma, Ze Lianga, Ying Zhuang, Litao Hu, Kexin Zhang, Leixiao Huang, Min Li*, Shubiao Zhang*, Yuhong Zhen*.Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer. International Journal of Biological Macromolecules.2025,308:142272. D O I：10.1016/j.ijbiomac.2025.142272
3. Defu Zhi, Jian Shi, Shaohui Cui, Ting Yang, Jian Yang, Wei Wang, Pengfei Ma, Yuhong Zhen,* and Shubiao Zhang*. Biodegradable Sucrose Ester-Based Cationic Lipids as Novel Vectors for Efficient and Safe Delivery of IGF-1R siRNA. ACS Materials Lett. 2023, 5, 862-873. D O I：10.1021/acsmaterialslett.2c00994
4. Sun Jiao, Li Min, Lin Kexin, Liu Zhanbiao, Wang Zhe, Wang Wei, Zhao Yinan*, Zhen Yuhong*, Zhang Shubiao*. Delivery of quercetin for breast cancer and targeting potentiation via hyaluronic nano-micelles. International Journal of Biological Macromolecules, 2023, 5: 124736. D O I：10.1016/j.ijbiomac.2023.124736
5.Rui Wang, Yang Xuan, Yinan Zhao, Wei Wang, Pengfei Ma, Benzhi Ju,* Yuhong Zhen,* Shubiao Zhang*. Cationic nanoparticulate system for codelivery of MicroRNA-424 and Podophyllotoxin as a multimodal anticancer therapy. Molecular Pharmaceutics. 2022,19(7):2092-2104. D O I：10.1021/acs.molpharmaceut.1c00962
6. Min Li, Yinan Zhao, Jiao Sun, Huiying Chen, Zhanbiao Liu, Kexin Lin, Pengfei Ma,Wenjun Zhang, Yuhong Zhen*, Shufen Zhang*, Shubiao Zhang*. pH/reduction dual-responsive hyaluronic acid-podophyllotoxin prodrug micelles for tumor targeted delivery. Carbohydrate Polymers, 2022, 288:119402 D O I：10.1016/j.carbpol.2022.119402


7. Yinan Zhao, Tianyi Zhao, Yingnan Cao, Jiao Sun, Quan Zhou, Huiying Chen, Shutao Guo, Yifeng Wang, Yuhong Zhen*, Xing-Jie Liang*, Shubiao Zhang*. Temperature-sensitive lipid-coated carbon nanotubes for synergistic photothermal therapy and gene therapy. ACS Nano, 2021, 15, 6517-6529. D O I：10.1021/acsnano.0c08790
8. Shuang Fu, Yinan Zhao, Jiao Sun, Ting Yang, Defu Zhi, Enxia Zhang, Fangli Zhong, Yuhong Zhen*, Shufen Zhang*, Shubiao Zhang*. Integrin αvβ3-targeted liposomal drug delivery system for enhanced lung cancer therapy. Colloids and Surfaces B: Biointerfaces, 2021, 201:111623. D O I：10.1016/j.colsurfb.2021.111623
9. Ze Liang, Linying Du, Enxia Zhang, Yinan Zhao, Wei Wang, Pengfei Ma, Mengyuan Dai, Qi Zhao, Hong Xu, Shubiao Zhang,* Yuhong Zhen*. Targeted-delivery of siRNA via a polypeptide-modified liposome for the treatment of gp96 over-expressed breast cancer. Materials Science & Engineering C 2021, 121:111847. D O I：10.1016/j.msec.2020.111847
10. Huiying Chen, Xuefeng Fan, Yinan Zhao, Defu Zhi, Shaohui Cui, Enxia Zhang, Haoming Lan,Jianjun Du, Zhen Zhang, Shubiao Zhang,* Yuhong Zhen*.Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor. ACS Applied Materials Interfaces 2020, 12: 22074-22087. D O I：10.1021/acsami.9b22440

*以上信息由高级会员个人更新和维护。