李孝训

男， 山东大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2003.09-2007.07，天津大学，本科
2007.09-2009.07，天津大学，硕士
2009.09-2014.12，美国威斯康星大学麦迪逊分校，博士
2015.03-2017.06，美国斯坦福大学，博士后
2017.12-至今，山东大学，教授

研究领域和兴趣

不对称催化，偶极环加成

主要业绩

独立工作以来，主要围绕“不对称催化合成精准构筑手性类药骨架”这一关键科学问题开展研究。运用过渡金属催化的环加成策略，设计开发新型1,3-或1,4-偶极子前体及其相关催化不对称新反应，为结构多样性的杂环化合物构建提供了高效、高立体选择性方法，并借此合成了数个含手性五元环或八元环的活性天然产物骨架（邀请综述：Chem. Rev. 2021, 121, 110以及近期代表性报道: J. Am. Chem. Soc. 2024, 146, 21069；ACS Catal. 2025, 15, 13207；ACS Catal. 2025, 15, 255；ACS Catal. 2021, 11, 14829；ACS Catal. 2021, 11, 2684；Chem. Sci. 2024, 15, 9361；Chem. Sci. 2022, 13, 3020; Chin. J. Chem. 2025, 43, 3157）。
申请人在该研究领域已有良好的积累，以通讯（共同通讯）作者先后在Chem. Rev., J. Am. Chem. Soc., ACS Catal., Chem. Sci., Chin. J. Chem., Org. Lett., Org. Chem. Front.等国际知名期刊发表论文16篇，申请中国专利8项（授权5项）。目前担任Pharmaceutical Science Advances青年编委。

代表成果

1. Xunhua Wang, Rongkai Gao, Xiaoxun Li*. Catalytic Asymmetric Construction of Chiral Polysubstituted 3-Azabicyclo[3.1.1]heptanes by Copper-Catalyzed Stereoselective Formal [4π+2σ] Cycloaddition. J. Am. Chem. Soc. 2024, 146, 21069-21077.
2. Mingjun Lv, Xinhui Yu, Jitian Liu, Xiaoxun Li*. Construction of Chiral C2-Quaternary Indolines via Palladium-Catalyzed Decarboxylative Asymmetric Amination. ACS Catal. 2025, 15, 255-264.
3. Xunhua Wang, Nana Li, Jianhua Wang, Xiaoxun Li*. Enantioselective Access to Complex [4.1.1] Scaffolds with All-Carbon Quaternary Stereocenters via Catalytic Asymmetric [4+3] Cycloaddition of Bicyclo[1.1.0]butanes. ACS Catal. 2025, 15, 13207-13215.
4. Can Gao,‡ Xunhua Wang,‡ Jitian Liu*, Xiaoxun Li*. Highly Diastereo- and Enantioselective Synthesis of Tetrahydrobenzo[b]azocines via Palladium-Catalyzed [4+4] Cycloaddition. ACS Catal. 2021, 11, 2684-2690.
5. Mingjun Lv, Xiaoxun Li*. Ni(II)-Catalyzed Asymmetric Nitration of Oxindoles: Construction of Cipargamin Analogues. ACS Catal. 2021, 11, 14829-14835.
6. Huan Zhang,‡ Chenchen Ma,‡ Fengfeng Yin, Yu Jiang, Jiaqi Du, Peifang Lu, Jianhua Wang,* Jitian Liu,* Xiaoxun Li*. Divergent Asymmetric Synthesis of Polycyclic Spiroindolines via Cascade Cycloadditions. Chin. J. Chem. 2025, 43, 3157-3164.
7. Xunhua Wang, Ruifeng Lv, Xiaoxun Li*. Kinetic Resolution of 1-(1-Alkynyl)cyclopropyl Ketones via Gold-Catalyzed Divergent (4+4) Cycloadditions: Stereoselective Access to Furan Fused Eight-Membered Heterocycles. Chem. Sci. 2024, 15, 9361-9368.
8. Jianhua Wang, Xiaoxun Li*. Asymmetric β-Arylation of Cyclopropanols Enabled by Photoredox and Nickel Dual Catalysis. Chem. Sci. 2022, 13, 3020-3026.
9. Xunhua Wang, Jianhua Wang*, Xiaoxun Li*. Stereoselective Access to Furan-fused [5.5.0] Bicyclic Heterocycles Enabled by Gold-catalyzed Asymmetric [8+4] Cycloaddition. Org. Chem. Front. 2025, 12, 159-166.
10. Jianhua Wang, Stephanie A. Blaszczyk, Xiaoxun Li*, Weiping Tang*. Transition Metal-Catalyzed Selective Carbon-Carbon Bond Cleavage of Vinylcyclopropanes in Cycloaddition Reactions. Chem. Rev. 2021, 121, 110-139.

*以上信息由高级会员个人更新和维护。