欧阳瑞镯

女， 上海理工大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2021.07-至今 上海理工大学材料与化学学院 沪江教授/硕士生导师
2012.09-2021.06 上海理工大学理学院 副教授/硕士生导师
2009.01-2011.12 美国田纳西大学化学系 分析化学/博士后
2005.09-2008.12 南京大学化学化工学院 分析化学/博士
2002.09-2005.06 河南师范大学化学化工学院 分析化学/硕士
2000.09-2002.06 河南师范大学化学化工学院 化学教育/学士
1997.09-2000.06 安阳师范学院 化学教育

研究领域和兴趣

铋生物医学、化学心理学

主要业绩

主要围绕铋基抗肿瘤及抗病毒药物的研发与作用机制研究、纳米技术在癌症诊疗一体化中的创新应用，以及智能传感与医学检测技术开发等方向，开展系统性、交叉性的科研工作，致力于推动化学、材料学、生物医学与临床转化之间的深度融合。

主持国家自然科学基金、上海市自然科学基金、上海市教育委员会科研创新项目以及医工交叉项目等科研课题共计7项，形成了较为稳定的研究方向和项目支撑体系。

以第一作者或通讯作者身份在 Bioactive Materials（IF=20.3）、Advanced Functional Materials（IF=19.4）、Materials Today Bio（IF=10.5）、Biosensors & Bioelectronics（IF=10.5）、Sensors and Actuators B: Chemical（IF=7.7）等国际权威期刊上发表SCI收录论文150余篇，其中中科院二区及以上论文50余篇，ESI高被引论文2篇，在相关领域产生了较好的学术影响力。

受聘担任上海市有色金属学会秘书长。目前担任 Scientific Reports 与 Frontiers in Analytical Science 副主编，《少年文学艺术》主编，《科学与人文艺术》副主编，以及 Nanomaterials、Molecules 期刊专刊客座主编，同时任《化学通讯》《当代化工》编委。此外，还担任多种国内外学术期刊的审稿人，积极参与学术共同体建设与期刊发展工作。

积极投身中小学生科普科创服务，常年为杨浦区中小学及上海理工大学教职工子女开展化学科普实践活动，并接待香港大浦中学及法国华裔学生开展暑期科普项目。与杨浦区少科站合作，担任区域优秀高中生科研探究活动基地指导教师，指导复旦附中、同济附中等多校学生开展科创项目，多次带领学生在上海市青少年科普科创大赛中获奖。曾获中国化学会“无处不化学”科普征文三等奖。在《科学画报》《十万个为什么》等期刊发表多篇科普文章，持续推动化学知识的社会传播与青少年科学素养提升。

本人对心理学有浓厚兴趣，尤其关注从化学视角探索心理现象背后的物质基础与生理机制。已发表化学与心理学交叉学科文章两篇（《心灵的诗意与身体的化学——一场内在的对话》《从分子到心灵：化学平衡与人类超越性的哲学统一》《藏在幸福背后的化学密码》），并于2025年12月接受中国科协之声专访，探讨以化学视角解读心灵。持有上海市心理学会与上海市教育人才交流协会联合颁发的上海市学校心理辅导与服务能力证书（中级），未来有意持续开展化学心理学相关的科普与研究工作。

代表成果

论文：
1. Conghao Liu, Minjie Yang, Runzhi Li, Yuqin Jiang, Dong Sun, Ruizhuo Ouyang, Yuqing Miao, Shuang Zhou*. Journal of Medicinal Chemistry, 2026. DOI: 10.1021/acs.jmedchem.5c02278
2. Minjie Yang, Meina Feng, Ling Zha, Xi Liu, Yuanhui Ma, Ying Huang, Ruizhuo Ouyang, Dong Sun, Yuqing Miao, Baolin Liu. Dual-cycle signal amplification on an Au@CeO₂₋ₓ/Bi₂MoO₆ platform: Toward an ultrasensitive and enzyme-free sandwich immunosensor for CA125 in clinical diagnostics. Biosensors and Bioelectronics, 2026, 301: 118511. DOI: 10.1016/j.bios.2026.118511
3. Yuanhui Ma, Xi Liu, Minjie Yang, Ling Zha, Ying Huang, Dong Sun, Ruizhuo Ouyang, Yuqin Jiang, Yuqing Miao, Baolin Liu. Femtomolar miRNA-21 detection in serum via a Y-shaped DNA assembly amplified catalytic hairpin assembly and Bi@PtAg nanocatalyst-driven electrochemical biosensor. Sensors and Actuators B: Chemical, 2026, 457: 139728. DOI: 10.1016/j.snb.2026.139728
4. Huihui Wang, Minjie Yang, Weixian Xue, Yuqin Jiang, Jie Tu, Chunyao Dong, Dong Sun, Ruizhuo Ouyang*, Yuqing Miao, Baolin Liu. A ‘targeting-and-control’ nanoplatform framework for precision gas therapy of cancer. Materials Today Chemistry, 2026, 52: 103456. DOI: 10.1016/j.mtchem.2026.103456
5. Qiupeng Zhang, Danrui Xiao, Conghao Liu, Jie Tu, Yanglei Song, Yuqin Jiang, Huihui Wang, Weixian Xue, Min Zhang, Shuang Zhou, Yuqing Miao, Ruizhuo Ouyang*, Jianbo Liu. One-dimensional Bi₂S₃ nanorod empowered synergistic photothermal/photocatalytic dual-modal therapy of breast cancer. Biomaterials Advances, 2026, 180: 214560. DOI: 10.1016/j.bioadv.2025.214560
6. Xi Liu, Minjie Yang, Yuqin Jiang, Dong Sun, Ruizhuo Ouyang*, Chengyi Lu, Yuqing Miao. Integrating amplification strategies and functional nanomaterials for advanced electrochemical biosensing of MicroRNA. Bioelectrochemistry, 2026, 168: 109170. DOI: 10.1016/j.bioelechem.2025.109170
7. Chengyi Lu, Minjie Yang, Peiwu Chen, Hongyi Zhang, Shi Tang, Ling Zha, Ying Huang, Dong Sun, Ruizhuo Ouyang, Yuqin Jiang, Yuqing Miao, Baolin Liu. Engineered LaBi₃O₆ nanosheet interface enabling robust and ultrasensitive detection of carcinoembryonic antigen. Bioelectrochemistry, 2026, 170: 108869. DOI: 10.1016/j.bioelechem.2026.108869
8. Conghao Liu, Yang Yang, Runzhi Li, Xiaoqing Zhang, Dionisio Zaldivar Silva, Yuefeng Zhao, Ruizhuo Ouyang, Yuqing Miao, Baolin Liu, Shuang Zhou. Enhanced Anticancer Activity of Novel Bi(III)-Thiosemicarbazone Complexes Against Lung Cancer. Applied Organometallic Chemistry, 2025, 39(4): e70249. DOI: 10.1002/aoc.70249
9. Qiupeng Zhang, Jie Tu, Yuqin Jiang, Huihui Wang, Weixian Xue, Chunyao Dong, Ruizhuo Ouyang, Yuqing Miao. Bismuth Based Nanomaterials: Design, Synthesis and Applications in Tumor Synergistic Therapy. Colloids and Surfaces B: Biointerfaces, 2025, 256: 114992. DOI: 10.1016/j.colsurfb.2025.114992
10. Ruizhuo Ouyang, Weixian Xue, Penghui Cao, Zhengang Sun, Huihui Wang, Xiaoqing Zhang, Shuang Zhou, Yuqing Miao. Superhydrophilic Bi-methylimidazole for Preferred pH-Responsive, Targeted Drug Delivery to Tumor. Colloids and Surfaces B: Biointerfaces, 2025, 253: 114701. DOI: 10.1016/j.colsurfb.2025.114701
11. Pengpeng Jia, Jie Tu, Hongyu Shen, Yuqin Jiang, Qiupeng Zhang, Weixian Xue, Meitong Liu, Jianbo Liu, Yuqing Miao, Ruizhuo Ouyang*, Shuang Zhou. Defect-Engineered Magnetic Bismuth Nanomedicine for Dual-Modal Imaging and Synergistic Lung Tumor Therapy. Materials Today Bio, 2025, 32: 101680. DOI: 10.1016/j.mtbio.2025.101680
12. Ruizhuo Ouyang, Meina Feng, Yuefeng Zhao, Jinyao Liu, Yuanhui Ma, Xi Liu, Baolin Liu, Yuqing Miao, Shuang Zhou. Cubic Na₀.₅Bi₀.₅TiO₃ nanoperovskite significantly expands the application of sensitive immunosensor for the detection of carcinoembryonic antigen. Microchimica Acta, 2024, 191(7): 381. DOI: 10.1007/s00604-024-06457-3
13. Ruizhuo Ouyang, Meina Feng, Yuefeng Zhao, Jinyao Liu, Yuanhui Ma, Xi Liu, Baolin Liu, Yuqing Miao, Shuang Zhou. Hydrangea-like TiO₂/Bi₂MoO₆ porous nanoflowers triggering highly sensitive electrochemical immunosensing to tumor marker. Microchimica Acta, 2024, 191(5): 262. DOI: 10.1007/s00604-024-06332-1
14. Ruizhuo Ouyang, Qiupeng Zhang, Penghui Cao, Yang Yang, Yuefeng Zhao, Baolin Liu, Yuqing Miao, Shuang Zhou. Efficient improvement in chemo/photothermal synergistic therapy against lung cancer using Bi@Au nano-acanthospheres. Colloids and Surfaces B: Biointerfaces, 2023, 222: 113116. DOI: 10.1016/j.colsurfb.2022.113116
15. Lan Jiang, Peiwu Chen, Jinyao Liu, Dong Sun, Chenyu Dai, Yuhao Li, Yuqing Miao, Ruizhuo Ouyang*. Enhanced catalytic amplification of mesoporous bismuth-gold nano-electrocatalyst triggering efficient capture of tumor marker. Colloids and Surfaces B: Biointerfaces, 2023, 220: 112924. DOI: 10.1016/j.colsurfb.2022.112924
16. Ruizhuo Ouyang, Weilun Zhang, Jinyao Liu, Yuhao Li, Jing Zhang, Lan Jiang, Yuefeng Zhao, Hui Wang, Chenyu Dai, Abel Ibrahim Balbin Tamayo, Baolin Liu, Yuqing Miao*. Pt Nanodot Inlaid Mesoporous NaBiOF Nanoblackberry for Remarkable Signal Amplification Toward Biomarker Detection. Microchimica Acta, 2023, 190(6): 214. DOI: 10.1007/s00604-023-05791-2
17. Ruizhuo Ouyang, Lan Jiang, Xianjin Xie, Ping Yuan, Yuefeng Zhao, Yuhao Li, Abel Ibrahim Balbin Tamayo, Baolin Liu, Yuqing Miao*. Ti₃C₂@Bi₂O₃ nanoaccordion for electrochemical determination of miRNA-21. Microchimica Acta, 2023, 190(2): 52. DOI: 10.1007/s00604-022-05625-7
18. Ruizhuo Ouyang, Shen Wang, Kai Feng, Conghao Liu, Dionisio Zaldivar Silva, Ying Chen, Yuefeng Zhao, Baolin Liu, Yuqing Miao, Shuang Zhou. Potent saccharinate-containing palladium(II) complexes for sensitization to cancer therapy. Journal of Inorganic Biochemistry, 2023, 244: 112205. DOI: 10.1016/j.jinorgbio.2023.112205
19. Zhu Yang, Junlei Yang, Liuhuan Yue, Bei Shen, Jing Wang, Yuqing Miao, Ruizhuo Ouyang, Yihong Liu*. Enhancement Effects and Mechanism Studies of Two Bismuth-Based Materials Assisted by DMSO and Glycerol in GC-Rich PCR. Molecules, 2023, 28(11): 4515. DOI: 10.3390/molecules28114515
20. Junlei Yang, Liuhuan Yue, Bei Shen, Zhu Yang, Jian Shao, Yuqing Miao, Ruizhuo Ouyang, Yihong Liu*. Exploring the Inhibitory Effect of AgBiS₂ Nanoparticles on Influenza Viruses. International Journal of Molecular Sciences, 2023, 24(12): 10223. DOI: 10.3390/ijms241210223
21. Ruizhuo Ouyang, Jinyao Liu, Shen Wang, Weilun Zhang, Kai Feng, Conghao Liu, Baolin Liu, Yuqing Miao*, Shuang Zhou. Virtual Screening-Based Study of Novel Anti-Cancer Drugs Targeting G-Quadruplex. Pharmaceutics, 2023, 15(5): 1414. DOI: 10.3390/pharmaceutics15051414
22. Yulong Zhang, Xueyu Liu, Chongrui Geng, Hongyu Shen, Qiupeng Zhang, Yuqing Miao, Jingxiang Wu, Ruizhuo Ouyang*. Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration. Nanomaterials, 2023, 13(3): 551. DOI: 10.3390/nano13030551
23. Hui Wang, Weitao Yang, Kexin Bian, Weiwei Zeng, Xiao Jin, Ruizhuo Ouyang, Yan Xu, Chenyu Dai, Shuang Zhou, Bingbo Zhang. Oxygen-Deficient BiOCl Combined with L-Buthionine-Sulfoximine Synergistically Suppress Tumor Growth through Enhanced Singlet Oxygen Generation under Ultrasound Irradiation. Small, 2022, 18(9): e2104550. DOI: 10.1002/smll.202104550
24. Ruizhuo Ouyang, Penghui Cao, Pengpeng Jia, Hui Wang, Tianyu Zong, Chenyu Dai, Jie Yuan, Yuhao Li, Dong Sun, Ning Guo, Yuqing Miao, Shuang Zhou*. Bistratal Au@Bi₂S₃ nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer. Bioactive Materials, 2021, 6(2): 386-403. DOI: 10.1016/j.bioactmat.2020.08.014
25. Hui Wang, Junlei Yang, Penghui Cao, Yuhao Li, Yuefeng Zhao, Shuang Zhou, Ruizhuo Ouyang*, Yuqing Miao. Functionalization of bismuth sulfide nanomaterials for their application in cancer theranostics. Chinese Chemical Letters, 2020, 31(12): 3015-3026. DOI: 10.1016/j.cclet.2020.04.047
26. Xinli Tian, Penghui Cao, Dong Sun, Zhongmin Wang, Mengkui Ding, Xiaoyu Yang, Yuhao Li, Ruizhuo Ouyang*, Yuqing Miao. Synthesis of Novel CeBi₀.₄O₃.₇ Nanofeather for Ultrasensitive Sandwich-Like Immunoassay of Carcinoembryonic Antigen. Applied Surface Science, 2020, 528: 146956. DOI: 10.1016/j.apsusc.2020.146956
27. Wei Yue, Meifeng Hao, Bin Yu, Ruizhuo Ouyang, Yuqing Miao. Using non-combustion explosion in H₂O/DMF to synthesize 3D Structure of Ultrathin Bi Nanofilm with High Catalytic Activity for p-Nitrophenol Reduction. Nanotechnology, 2020, 31(14): 145717. DOI: 10.1088/1361-6528/ab6688
28. Ruizhuo Ouyang, Yang Yang, Xiao Tong, Kai Feng, Yaoqin Yang, Huihong Tao, Xiaoshen Zhang, Tianyu Zong, Penghui Cao, Fei Xiong, Ning Guo, Yuhao Li, Yuqing Miao, Shuang Zhou*. Potent Anticancer Activity of a New Bismuth (III) Complex against Human Lung Cancer Cells. Journal of Inorganic Biochemistry, 2017, 168: 18-26. DOI: 10.1016/j.jinorgbio.2016.12.005
29. Weiwei Li, Ruizhuo Ouyang, Wangyao Zhang, Shuang Zhou, Yang Yang, Yajun Ji, Yang Yang, Kai Feng, Liang Xiaocai, Mingshu Xiao, Yuqing Miao. Single Walled Carbon Nanotube Sandwiched Ni-Ag Hybrid Nanoparticle Layers for the Extraordinarily Electrocatalysis toward Glucose Oxidation. Electrochimica Acta, 2016, 188: 197-209. DOI: 10.1016/j.electacta.2015.11.124
30. Wangyao Zhang, Yang Yang, Fenfen Li, Guosheng Song, Yong Shao, Ruizhuo Ouyang, Lina Xu, Weiwei Li, Yuqing Miao. A Newly Prepared Ni(OH)₂@Cr(OH)₃ Nanohybrid for its Biocatalysis. Sensors and Actuators B: Chemical, 2014, 198: 350-359. DOI: 10.1016/j.snb.2014.03.073
31. Yuqing Miao, Ouyang Lei, Zhou Shilin, Lina Xu, Zhuoyuan Yang, Mingshu Xiao, Ruizhuo Ouyang. Electrocatalysis and Electroanalysis of Nickel, its Oxides, Hydroxides and Oxyhydroxides toward Small Molecules. Biosensors & Bioelectronics, 2014, 53: 428-439. DOI: 10.1016/j.bios.2013.10.008
32. Ruizhuo Ouyang, Wangyao Zhang, Shilin Zhou, Ziling Xue, Lina Xu, Yingying Gu, Yuqing Miao. Improved Bi Film Wrapped Single Walled Carbon Nanotubes for Ultrasensitive Electrochemical Detection of Trace Cr(VI). Electrochimica Acta, 2013, 113: 686-693. DOI: 10.1016/j.electacta.2013.09.105
33. Yuqing Miao, Zhuoyuan Yang, Xiaoyan Liu, Lina Xu, Lei Ouyang, Yingying Gu, Haizhou Chang, Ruizhuo Ouyang. Self-Assembly of Bi-III Ultrathin Layer on Pt Surface for Non-Enzymatic Glucose Sensing. Electrochimica Acta, 2013, 111: 621-626. DOI: 10.1016/j.electacta.2013.08.052
专利：
1. 欧阳瑞镯;吴镜湘;蒋琦亮;耿崇瑞;杨旻杰;缪煜清；近红外光响应的铋基纳米复合材料检测CTC的方法，2024，CN 119510345 B，2026，ZL 2024 1 1717592.9。

*以上信息由高级会员个人更新和维护。