刘妍君

女， 复旦大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1998-2002 河南师范大学 化学与环境科学学院，学士
2002-2008 武汉大学 化学与分子科学学院，博士
2008-2011 法国居里研究所，博士后研究员
2011-2013 法国巴黎高师，博士后研究员
2013-2016 法国居里研究所，Research Associate
2016-至今 复旦大学 生物医学研究院，教授

研究领域和兴趣

微流控芯片，细胞微环境，细胞分析

主要业绩

本人多年来一直致力于微流控芯片与生物医学多学科高度交叉科学研究。围绕“体内受限微环境如何决定细胞行为与命运”这一前沿科学问题，系统构建了从细胞微环境重构、单细胞纳米尺度动态解析到组织尺度功能化仿生平台的研究体系。首次提出“受限力学微环境驱动细胞迁移模式转变”的新范式，将空间受限确立为决定细胞迁移可塑性的核心调控变量，重构了细胞迁移调控的理论框架（Cell, 2015），引发了国际学术研究热点。原创突破超微量蛋白质组学与自监督超分辨活细胞成像关键技术瓶颈，实现纳米尺度单分子动态实时追踪（Nature Methods, 2026；Anal. Chem., 2022）。在此基础上，申请人进一步系统揭示受限微环境通过代谢重排、核骨架重塑及核力学转导影响染色质结构与表观状态，建立“受限—代谢—核结构—命运输出”的跨尺度调控链条（PNAS, 2024；Cell Research 2026; Nano Lett., 2023；ACS Nano, 2026; EMBO Reports 2025）。构建血管化患者来源肿瘤类器官等多器官仿生芯片平台（Adv. Mater., 2025；Talanta 2024；Anal. Chem., 2023），打通基础机制解析与精准医学评估之间的技术路径。上述工作推动了细胞微环境研究由结构模拟迈向命运调控机制解析阶段，在生物医学交叉领域形成了具有国际影响力的原创研究方向。

代表成果

1. Yan-Jun Liu, Mael Le Berre, Franziska Lautenschlaeger, Paolo Maiuri, Andrew Callan Jones, Mélina Heuzé, Tohru Takaki, Raphaël Voituriez, and Matthieu Piel, Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells. Cell, 2015, 160, 659-672. (IF 66.85, 一区)
2. Jiahao Liu, Xue Dong, Huaide Lu, Tao Liu, Wei Liu, Xinyao Hu, Quan Meng, Amin Jiang, Tao Jiang, Xiaohan Geng, Haosen Liu, Jun Cheng, Edmund Y. Lam, Yan-Jun Liu*, Shan Tan*, Dong Li*, Bio-friendly and high-precision super-resolution imaging through self-supervised reconstruction structured illumination microscopy, Nature Methods, 2026, 23, 395–404. https://doi.org/10.1038/s41592-025-02966-y (IF 32.1, 一区)
3. Yixin Liu, Ya-Jun Wang, Yang Du, Wei Liu, Xuedong Huang, Zihui Fan, Jiayin Lu, Runqiu Yi, Xiao-Wei Xiang, Xinwei Xia, Hongzhou Gu, Yan-Jun Liu*, Baohong Liu*, DNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution, PNAS, 2024, 121(14): e2317492121. (IF 11.1, 一区)
4. Yang Du, Yi-Ran Wang, Qi-Yuan Bao, Xin-Xin Xu, Congling Xu, Shaoxuan Wang, Qi Liu, Fan Liu, Yu-Lian Zeng, Ya-Jun Wang, Wei Liu, Yixin Liu, Sai-Xi Yu, Yu-Chen Chen, Chen Wang, Weibin Zhang, Hai Gao, Hao Luo, Baohong Liu, Guangyin Jing, Ming Guo, Fei Xavier Chen, Yan-Jun Liu*, Personalized Vascularized Tumor Organoid-on-a-Chip for Tumor Metastasis and Therapeutic Targeting Assessment, Advanced Materials, 2025, 2412815. DOI: 10.1002/adma.202412815 (IF 27.4, 一区)
5. Min Liu, Bing Liu, Chen Chen, Yi-Ran Wang, Xiaoyan Li, Yajuan Zhang, Xinyang Liu, Dingpei Zhou, Hong Gao, Yijun Qi, Chen Su, Dong Gao, Yun Zhao, Yan-Jun Liu*, Quanlin Li*, Weiwei Yang*, Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement, Cell Research, 2026, 36, 513-530. https://doi.org/10.1038/s41422-026-01254-4 (IF 25.9, 一区)
6. Yu-Chen Chen, Yixin Liu, Sai-Xi Yu, Ya-Jun Wang, Wei Liu, Yuxian Liao, Xue-Zhu Chen, Hai Gao, Baohong Liu, and Yan-Jun Liu*, Curved Microfluidic Confinement Reveals Cell-Shape-Dependent Nuclear Mechanotransduction in Adaptive Migration, ACS Nano, 2026, 20, 1, 998–1009. https://doi.org/10.1021/acsnano.5c16455 (IF 16.0, 一区)
7. Ya-Jun Wang, Hong Liang, Yixin Liu, Qiyuan Bao, Shuang Yang, Xin-Xin Xu, Yu-Chen Chen, Wei Liu, Xuemeng Shi, Yuheng Shi, Xiaohui Liu, Baohong Liu, Hai Gao, Yaming Jiu, Yan-Jun Liu*，Lamin A/C and vimentin as a coordinated regulator during amoeboid migration in microscale confined microenvironments. Nano Letters, 2023, 23, 14, 6727–6735. https://doi.org/10.1021/acs.nanolett.3c02096 (IF 12.26, 一区)
8. Yu-Lian Zeng, Yang Du, Xin-Xin Xu, Ya-Jun Wang, Sai-Xi Yu, Ting Liu, Shiyuan Luo, Xiao-Wei Xiang, Wei Liu, Yu-Chen Chen, Hongjun Huang, Hai Gao, Yuhui Shen, Yan Luo, Chengrong Bao, Yan-Jun Liu*, On-chip modeling of physiological and pathological blood-brain barrier microenvironment for studying glial response to neuroinflammation, Nano Today, 2023, 101947. (IF 18.96, 一区)
9. Sai-Xi Yu, Yi Wu, Hao Luo, Yanan Liu, Yu-Chen Chen, Ya-Jun Wang, Wei Liu, Jianan Tang, Huijuan Shi, Hai Gao, Guangyin Jing, Yan-Jun Liu*, Escaping behavior of sperms on biomimetic oviductal surface, Analytical Chemistry, 2023, 95, 2366-2374. https://doi.org/10.1021/acs.analchem.2c04338 (IF 8.0, 一区)
10. Yixin Liu, Zihui Fan, Xiao-Wei Xiang, Xiaonan Tao, Xinwei Xia, Qian Shi, Yanwei Lu, Jiayin Lu, Hongzhou Gu, Yan-Jun Liu*, Baohong Liu*, Engineering of multivalent membrane-anchored DNA frameworks for precise profiling of variable membrane permeability during reversible electroporation, Small Methods, 2023, 2301198. (IF 15.37, 一区)

*以上信息由高级会员个人更新和维护。