何学文

男， 苏州大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

教育经历：
2005-2009，华中科技大学，生物学学士
2009-2012，华中科技大学，生物医学工程硕士
2016-2019，香港科技大学，化学博士

工作研究经历：
2012-2016，苏州大学材料与化学化工学部科研助理
2019-2021，香港科技大学化学与生物工程系博士后
2021至今，苏州大学材料与化学化工学部特聘教授

研究领域和兴趣

功能发光探针制备、病原微生物检测分析、疾病标志物检测、核酸自组装

主要业绩

研究聚焦新型荧光探针工具和生化分析方法，围绕疾病标志物、病原微生物分析检测展开。近五年以通讯（包含共同通讯）作者在 Natl. Sci. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano, Adv. Funct. Mater., Chem. Sci., Anal. Chem., Aggregate 等发表25篇论文，总引用超过6600次，H-指数40；主持国家自然科学基金青年基金、面上项目、海外优青等项目，申请中国/美国发明专利18项，授权9项。

代表成果

1. Jiangtao Geng#, Jie Sun#, Ling-Hong Xiong, Fulong Ma, Yinzhe Chen, Qian Zhang, Ben Zhong Tang, Xuewen He*. In Situ Activating A Protein-Complexed Quenched Probe via Alkaline Phosphatase Response for Pyroptosis-Mediated Cancer Immunotherapy. Angew. Chem. Int. Ed. 2026, 65: e897682. https://doi.org/10.1002/anie.8976820

2. Jing Zhang, Ling-Hong Xiong, Ben Zhong Tang, Xuewen He*. Engineering Bacteriophage Cocktail with Mutually Promoted Chemodynamic-Photodynamic Activity for Targeted and Synergistic Biofilm Eradication. ACS Nano 2026, 20(7), 6063–6080. https://doi.org/10.1021/acsnano.5c19780

3. Jie Sun, Ling-Hong Xiong, Ben Zhong Tang*, Xuewen He*. MicroRNA-triggered In Situ Programmed Assembly of Photosensitizers with Controlled Dimension and Accelerated Kinetics for Precise Cancer Therapy. National Science Review 2026, 13(1), nwaf424. https://doi.org/10.1093/nsr/nwaf424.

4. Kristy W. K. Lam, Yaojia Zhang, Wutong Du, Jie Sun, Feiyi Sun, Yuyang Chen, Charlie C. H. Ma, Jacky W. Y. Lam, Ryan T. K. Kwok*, Jianwei Sun, Xuewen He*, Ben Zhong Tang*. A Nitroreductase-Responsive Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Precise Hypoxic Cancer Theranostics. ACS Nano 2025, 19(27), 10216–10231. https://doi.org/10.1021/acsnano.4c16139

5. Zhenyue Su, Ling-Hong Xiong*, Jing Zhang, Ben Zhong Tang*, Xuewen He*. Targeted Recognition, Fluorescent Tracking and Augmented Killing of Multi-bacterial Infections via Synergizing a Magnetic Bead-armored Phage Cocktail with Enzyme-activated AIE Probes. Chem. Sci. 2025, 16, 10288–10299. https://doi.org/10.1039/D5SC01072A

6. Yi Wang, Yueping Li, Mengyu Li, Keyi Tang, Shufeng Zhou, Jie Sun, Ruru Zhang, Chanyuan Liu, Yan Liu, Chunyi Liu*, Ruixue Duan*, Xuewen He*. WOx Nanosheets Enhance Acute Kidney Injury Therapy Through Geometry-Improved Targeting and Antioxidant Properties. Aggregate 2025, 6(8), e70101. https://doi.org/10.1002/agt2.70101

7. Ling-Hong Xiong#, Pengtong Hu#, Jing Zhang, Jie Sun, Jiangtao Geng, Ming-Peng Zhuo, Ben Zhong Tang*, Xuewen He*. Photosensitizing Quantum Dot Killers Encoded by Bivalent DNA for Sequential Cell Penetration, Intracellular Bacterial Imaging, and Targeted Elimination. ACS Nano 2025, 19(8), 5452–5465. https://doi.org/10.1021/acsnano.4c14792

8. Yaojia Zhang#, Jie Sun#, Ling-Hong Xiong, Xuewen He*. Near-Infrared Photoaccelerated MicroRNA Response for Image-Guided Photodynamic-Chemodynamic Synergistic Cancer Therapy via Nanoprobe Programmed Disassembly. Adv. Funct. Mater. 2025, 35(46), 2509090. https://doi.org/10.1002/adfm.202509090

9. Jie Sun, Jiangtao Geng, Ben Zhong Tang*, Xuewen He*. DNA-Programmed (De)Hybridization of Near-Infrared Photosensitized UCNP-QDs-GNPs Nanoprobes for MicroRNA Imaging and Image-Guided Cancer Therapy. Adv. Funct. Mater. 2024, 34(23), 2315299. https://doi.org/10.1002/adfm.202315299

10. Ling-Hong Xiong*, Langyi Yang, Jiangtao Geng, Ben Zhong Tang*, Xuewen He*. All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and Combinational Chemodynamic–Photodynamic Therapy. ACS Nano 2024, 18(27), 17511–17524. https://doi.org/10.1021/acsnano.4c03879

*以上信息由高级会员个人更新和维护。