张发光

男， 天津大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2005-2009：学士，天津大学，中国
2009-2014：博士，天津大学，中国（导师：马军安 教授）
2014-2017：博士后，以色列理工学院，以色列（导师：Ilan Marek教授）
2017-2023：副教授，天津大学，中国
2023-现在：教授，天津大学，中国

研究领域和兴趣

有机氟化学、不对称合成、酶催化

主要业绩

张发光，天津大学菁英教授，博士生导师，主持国家自然科学基金青年项目B类。研究方向为有机氟化学，近年来主要在新型含氟砌块设计合成与反应研究、化学-酶法合成含氟新分子方面取得了系列成果，以第一或(共同)通讯作者在Chem. Rev.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等高水平期刊发表学术论文70余篇，参编英文专著2部，申请/授权国家发明专利10余项，获得“Chem Comm Pioneering Investigators 2025”、“Chin J Chem Emerging Investigators 2025”、天津市优秀硕士学位论文指导教师、天津市青年科技优秀人才等荣誉奖励，担任Academia Catalysis编委。主持国家自然科学基金青年项目B类（原优青）、国家重点研发计划催化科学重点专项子课题、国际合作项目、面上项目、青年项目(已结题)、天津市自然科学基金青年项目(已结题)、国家重点研发计划合成生物学重点专项子课题(已结题)等。

代表成果

1) Ze-Long Mei, Jia-Xin Guo, Zhoutong Sun, Jun-An Ma, and Fa-Guang Zhang*, Biosynthesis of Fluorinated Aromatic Polyketides Through Directed Evolution of Fused Type III Polyketide Synthase, Angew. Chem. Int. Ed. 2026, 65(40), e3691732.
2) Hong-Song Shi,† Yi-Dan Miao,† Xiaodong Tang, Heng-Ying Xiong, Jing Nie, Yanfeng Dang,* Jun-An Ma,* and Fa-Guang Zhang*, Catalytic Enantioselective Decarboxylative Cross-Coupling of β-Ketoacids With gem-Difluoroallenes Enabled by Fluorine-Induced Allylrhodium Isomerization, Angew. Chem. Int. Ed. 2026, 65(19), e4973244.
3) Ting-Yu Fang, Meng-Ye Jiang, Meng-Meng Zheng, Jun-An Ma, and Fa-Guang Zhang*, SH2 Decarboxylative Monofluoromethylation of Aliphatic Carboxylic Acids Enabled by Nickel/Photoredox Dual Catalysis. Angew. Chem., Int. Ed. 2025, 64, e202507632.
4) Shuo-Han Li,† Xue Zhang,† Ze-Long Mei, Yongjun Liu,* Jun-An Ma,* and Fa-Guang Zhang* Chemoenzymatic Synthesis of Fluorinated Mycocyclosin Enabled by the Engineered Cytochrome P450-Catalyzed Biaryl Coupling Reaction. J. Am. Chem. Soc. 2024, 146, 19962−19973.
5) Xiaodong Tang†, Ming-Yue He†, Ran Guo, Hao-Nan Liu, Jing Nie, Ilan Marek, Jun-An Ma, Fa-Guang Zhang* The Smallest Monofluorodiazoethane Reagent and Its [3 + 2] Cycloaddition Reactions. CCS Chem. 2024, 6, 2825–2834.
6) Xuan-Yu Liu,† Yi-Lin Yang,† Yanfeng Dang, Ilan Marek,* Fa-Guang Zhang,* and Jun-An Ma,* Tetrazole Diversification of Amino Acids and Peptides via Silver-Catalyzed Intermolecular Cycloaddition with Aryldiazonium Salts. Angew. Chem. Int. Ed. 2023, 62(37), e202304740.
7) Jun-Hao Zhang,† Hui Xu,† Xiaodong Tang, Yanfeng Dang*, Fa-Guang Zhang*, and Jun-An Ma*, Highly Enantio- and Diastereoselective Hydrogenation of Cyclic Tetra-Substituted β-Enamido Phosphorus Derivatives. Angew. Chem., Int. Ed. 2023, 62(28), e20230531.
8) Zhi-Qi Zhang,† Yue-Qian Sang,† Cheng-Qiang Wang, Peng Dai, Xiao-Song Xue, Jared L. Piper, Zhi-Hui Peng, Jun-An Ma,* Fa-Guang Zhang,* and Jie Wu*, Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer. J. Am. Chem. Soc. 2022, 144(31), 14288−14296.
9) Zhi-Qi Zhang, Meng-Meng Zheng, Xiao-Song Xue, Ilan, Marek,* Fa-Guang Zhang,* and Jun-An Ma* “Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three-Membered Carbocycles” Angew. Chem., Int. Ed. 2019, 58(50), 18191–18196.
10) Fa-Guang Zhang and Ilan Marek,* “Brook Rearrangement as Trigger for Carbene Generation: Synthesis of Stereodefined and Fully Substituted Cyclobutenes” J. Am. Chem. Soc. 2017, 139(24), 8364−8370.

*以上信息由高级会员个人更新和维护。