戴伟民

男， 香港科技大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1978.10–1982.07，杭州大学化学系本科学生
1982.08–1984.12，中国科学院上海有机化学研究所硕士研究生
1985.01–1985.09，中国科学院上海有机化学研究所博士研究生
1985.10–1990.04，日本京都大学化学研究所博士研究生
1990.05–1992.08，美国Scripps研究所博士后研究员
1992.09–1997.12，香港科技大学化学系助理教授
1998.01–2007.06，香港科技大学化学系副教授
2007.07–2023.06，香港科技大学化学系教授
2023.07–, 香港科技大学化学系荣休教授及兼任教授

研究领域和兴趣

不对称催化和立体选择反应，具有生物医药意义分子的合成，海洋大环内酯和其它复杂天然产物的全合成

主要业绩

1. 建立了用烯丙基重排合成共轭烯二炔的独特方法并用于烯二炔类抗癌剂前药的设计和合成。
2. 开发了独有的基于芳基甲酰胺骨架的Aphos系列磷氧半稳定双配位配体，用于室温条件下的氯代芳烃和卤代烯烃的Suzuki–Miyaura偶联反应，底物适用范围广，在大环内酯类天然产物全合成中得到了应用。其中含轴手性Aphos系列配体已应用于不对称烯丙基烷基化反应、不对称Heck反应、及不对称Suzuki–Miyaura偶联反应。
3. 开展了多样性导向有机合成、微波辅助有机合成及组合化学等研究，建立了合成多种杂环的新方法，发展了微波辅助Ugi四组分反应及后续环化反应相结合的合成策略，用于杂环化合物的高效合成。
4. 建立了多模块组装（multimodule assembly）的合成策略，用于海洋大环内酯类天然产物的多样性全合成，已经完成基于高级共同中间体的Amphidinolide T系列5个大环内酯及其类似物的全合成和基于烯烃闭环复分解反应的Amphidinolide X和Y、24-Demethylbafilomycins、Mycolactone E、Iriomoteolide-1a/-1b立体异构体、Palmyrolide A、及Laingolides等的全合成。

代表成果

1. Wei-Min Dai,* Kin Chiu Fong, Hiroshi Danjo, and Sei-ichi Nishimoto, Synthesis of cis-Enediynes from 1,5-Diynes by Rearrangement of an Allylic Double Bond, Angew. Chem. Int. Ed. Engl. 1996, 35, 779–781. [DOI: 10.1002/anie.199607791]
2. Wei-Min Dai,* Kwong Wah Lai, Anxin Wu, Wataru Hamaguchi, Mavis Yuk Ha Lee, Ling Zhou, Atsushi Ishii, and Sei-ichi Nishimoto, DNA Cleavage Potency, Cytotoxicity, and Mechanism of Action of a Novel Class of Enediyne Prodrugs, J. Med. Chem. 2002, 45, 758–761. [DOI: 10.1021/jm015588e]
3. Wei-Min Dai,* Kelly Ka Yim Yeung, Jin-Ting Liu, Ye Zhang, and Ian D. Williams, A Novel Class of Nonbiaryl Atropisomeric P,O-Ligands for Palladium-Catalyzed Asymmetric Allylic Alkylation, Org. Lett. 2002, 4, 1615–1618. [DOI: 10.1021/ol0258233]
4. Wei-Min Dai,* Dian-Shun Guo, Li-Ping Sun, and Xiang-Hong Huang, Microwave-Assisted Solid-Phase Organic Synthesis (MASPOS) as a Key Step for an Indole Library Construction, Org. Lett. 2003, 5, 2919–2922. [DOI: 10.1021/ol0350543]
5. Li-Ping Sun and Wei-Min Dai*, An Engineered Linker Capable of Promoting On-Resin Reactions for Microwave-Assisted Solid-Phase Organic Synthesis, Angew. Chem. Int. Ed. 2006, 45, 7255–7258. [DOI: 10.1002/anie.200602523]
6. Jian Jin, Yile Chen, Yannian Li, Jinlong Wu, and Wei-Min Dai*, Total Synthesis of Amphidinolide Y by Formation of Trisubstituted (E)-Double Bond via Ring-Closing Metathesis of Densely Functionalized Alkenes, Org. Lett. 2007, 9, 2585-2588. [DOI: 10.1021/ol0710360]
7. Wei-Min Dai,* Yannian Li, Ye Zhang, Congyong Yue, and Jinlong Wu, Generation of an Aromatic Amide-Derived Phosphane (Aphos) Library by Self-Assisted Molecular Editing and Applications of Aphos in Room-Temperature Suzuki-Miyaura Reactions, Chem. Eur. J. 2008, 14, 5538–5554. [DOI: 10.1002/chem.200800318]
8. Huoming Li, Jinlong Wu, Jialu Luo, and Wei-Min Dai,* A Concise Total Synthesis of Amphidinolide T2, Chem. Eur. J. 2010, 16, 11530–11534. [DOI: 10.1002/chem.201001794]
9. Chengsen Cui and Wei-Min Dai,* Total Synthesis of Laingolide B Stereoisomers and Assignment of Absolute Configuration, Org. Lett. 2018, 20, 3358–3361. [DOI: 10.1021/acs.orglett.8b01269]
10. Jingjing Xu, Benguo Lin, Xiuqing Jiang, Zejun Jia, Jinlong Wu,* and Wei-Min Dai,* Intramolecular Diels−Alder Cycloaddition Approach toward the cis-Fused D5,6-Hexahydroisoindol-1-one Core of Cytochalasins, Org. Lett. 2019, 21, 830–834. [DOI: 10.1021/acs.orglett.8b04129]
11, Man Ki Sit, Hui Hui Cao, Yan-Dong Wu, Tsz Chun Yip, Lars Eric Bendel, Wen Zhang, and Wei-Min Dai,* Synthesis of the Macrolactone Cores of Maltepolides via a Diene–Ene Ring-Closing Metathesis Strategy, Org. Lett. 2023, 25, 1633–1637. [DOI: 10.1021/acs.orglett.3c00106]

*以上信息由高级会员个人更新和维护。