燕红

女， 南京大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

(1) 1983.09-1987.06, 内蒙古大学化学系, 本科学生
(2) 1987.09-1990.06, 内蒙古大学化学系, 硕士生
(3) 1990.09-1993.10, 南京大学化学系, 博士生
(4) 1993.11-1995.03, 南京大学配位化学研究所, 讲师
(5) 1995.04-1996.10, 瑞士University of Neuchâtel 化学研究所，博士后
(6) 1997.11-2000.09, 德国University of Bayreuth 无机化学研究所，博士后
(7) 2000.10-2004.12, 美国 University of Notre Dame 化学与生化系, 副研究员
(8) 2005.01-2005.08, 美国 Nanova Inc. 研发中心, 高级化学家
(9) 2005.08 至 今, 南京大学化学与化工学院, 教授

研究领域和兴趣

化学合成， 发光材料及含硼药物

主要业绩

南京大学燕红教授, 国家杰出青年基金获得者。1998年开始硼簇化学研究至今，从多面体硼烷、碳硼烷、到金属硼烷、再到金属碳硼烷。从新结构发现，到惰性B–H键活化及功能化方法的探索及机理研究，再到发光材料、传感、生物成像、生物活性及硼中子捕获疗法（BNCT）抗癌药物的研发，25年来涉及了硼簇研究的很多方面，在这一领域积累了丰富的经验。具体如下：（1）在硼簇合成化学方面，通过金属活化及光、电介导等手段实现了碳硼烷惰性B–H键官能团化，获得了各类含B–X键的新型功能化产物，其中包括一些高效、实用、简洁的合成策略，建立了功能化碳硼烷分子库，为碳硼烷的应用奠定了基础；（2）利用碳硼烷独特的电子效应、空间位阻效应、三维芳香性、热稳定性等性质，成功调控了各类发光分子的光物理性质，获得了一系列有应用前景的发光材料如有机单分子白光材料、近红外发光材料、电致发光材料、OLED材料等，进一步将碳硼烷衍生物应用到生物成像、传感等领域；（3）发现了硼簇特有的几类非共价键，如B−H---π、cage---π、cage---cage，cage---卤键等，丰富和发展了已有的非共价键类型，揭示了这些非共价键的本质并发展其在调控发光、高效光热转化以及光催化等方面的应用；（4）自2006年起致力于碳硼烷衍生物的生物活性研究，包括活体内靶向BNCT硼携带剂的荧光示踪成像研究，获得了一批具有生物成像及较高生物活性的新型碳硼烷衍生物，为硼簇的诊疗一体化BNCT靶向药物的研究奠定了基础。自2020年起首次结合聚集诱导发光（AIE）成像构建了肺癌靶向的新型硼簇携带剂，并获得了良好的中子照射治疗效果，为进一步的硼携带剂的开发积累了经验。
已发表了包括 Sci. Adv., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun.等在内的200篇相关学术论文，授权国内发明专利15件。一些工作获国内外同行的好评及各类媒体报道及评论，包括多次被Angew. Chem. Int. Ed. (VIP, hot paper, cover picture), J. Am. Chem. Soc. (spotlight, front cover)，Chemical and Engineering News, Chemistry World, 国家自然科学基金委网站及其杂志等评价。

获得荣誉与奖励如下：

1. 2009年获国家自然科学基金委杰出青年基金
2. 2022年被评为山东省“泰山产业领军人才”
3. 2012年获教育部自然科学二等奖， 王雪梅， 陈宝安， 燕红，姜辉， 基于纳米生物技术的肿瘤耐药性识别与抑制研究
4. 2013年获江苏省自然科学三等奖，王雪梅， 陈宝安， 燕红，基于纳米簇仿生功能界面的肿瘤相关生物监测与多模态成像方法；
5. 1997年获国家教委科技进步二等奖，陈慧兰，燕红，韩德艳，辅酶B12化合物及脱氧核苷类似物的研究；
6. 为美国化学会Organometallics 国际编委（2013-2015，2019-2023）；
7. 担任国际硼化学会议顾问委员（2023-）。

代表成果

1. Wenli Ma, Jianyu Zhang, Jibo Zong, Hongyuan Ren, Deshuang Tu, Qinfeng Xu, Ben Zhong Tang, Hong Yan,* Luminescence modulation in boron-cluster-based luminogens via boron isotope effects, Angew. Chem. Int. Ed. 63(2024), e202410430.
2. Zhaofeng Sun, Jibo Zong, Hongyuan Ren, Changsheng Lu, Deshuang Tu, Jordi Poater, Miquel Solà, Zhuangzhi Shi, Hong Yan,* Couple-close construction of non-classical boron cluster-phosphonium conjugates, Nat. Commun. 15 (2024), 7934.
3. Hongyuan Ren, Ningning Zhou,WenliMa, Ping Zhang, Deshuang Tu, Chang-sheng Lu, Hong Yan,* Dative bonding activation enables precise functionalization of the remote B–H bond of nido-carborane clusters, J. Am. Chem. Soc. 146 (38) (2024), 26543–26555.
4. Shengwen Xu, Hongjian Zhang, Jingkai Xu, Weiqun Suo, Chang-Sheng Lu, Deshuang Tu, Xingwei Guo, Jordi Poater, Miquel Solà, Hong Yan,* Photoinduced selective B−H activation of nido-carboranes, J. Am. Chem. Soc.146 (11) (2024), 7791–7802.
5. Hongyuan Ren, Ping Zhang, Jingkai Xu, Wenli Ma, Deshuang Tu, Chang-sheng Lu, Hong Yan,* Direct B–H functionalization of icosahedral carboranes via hydrogen atom transfer, J. Am. Chem. Soc. 145 (13) (2023), 7638–7647.
6. Fangxiang Sun, Shuaimin Tan, Hou-Ji Cao, Chang-sheng Lu, Deshuang Tu, Jordi Poater, Miquel Solà, Hong Yan,* Facile Construction of New Hybrid Conjugation via Boron Cage Extension, J. Am. Chem. Soc. 145 (6) (2023), 3577–3587.
7. Ronghui Huang, Hong Deng, Jingkai Xu, Minyan Wang, Hong Yan*, Yue Zhao, Zhuangzhi Shi, Stereospecific nickel-catalyzed [4+2] heteroannulation of alkynes with aminophosphanes, Sci. Adv. 9 (2) (2023), eade8638.
8. Miao Zhu , Qin Zhou, He Cheng, Ye Sha, Vladimir I. Bregadze, Hong Yan,* Zhe Sun, Xiang Li, Boron-cluster embedded necklace-shaped nanohoops, Angew. Chem. Int. Ed. 62 (1) (2023), e202213470.
9. Meng Chen, Jingkai Xu, Deshi Zhao, Fangxiang Sun, Songlin Tian, Deshuang Tu, Changsheng Lu, Hong Yan*, Site-selective functionalization of carboranes at electron-rich boron vertex: Photocatalytic B-C coupling via a carboranyl cage radical, Angew. Chem. Int. Ed. 61 (37) (2022), e202205672.
10. Fangxiang Sun, Shuaimin Tan, Hou-Ji Cao, Jingkai Xu, Vladimir I. Bregadze, Deshuang Tu, Changsheng Lu, Hong Yan,* Palladium-catalyzed hydroboration of alkynes with carboranes: Facile construction of a library of boron cluster-based AIE-active luminogens, Angew. Chem. Int. Ed. 61 (33) (2022), e202207125.
11. Ye Sha, Zhou Zhou, Miao Zhu, Zhenyang Luo, Enhua Xu, Xiang Li, Hong Yan,* The mechanochemistry of carboranes, Angew. Chem. Int. Ed. 61 (20) (2022), e202203169.
12. Deshuang Tu, Jianyu Zhang, Yunxiao Zhang, Herman H. Y. Sung, Lijie Liu, Ryan T. K. Kwok, Jacky W. Y. Lam, Ian D. Williams, Hong Yan*, Ben Zhong Tang, How do molecular motions affect structures and properties at molecule and aggregate levels? J. Am. Chem. Soc. 143 (30) (2021), 11820–11827.
13. Meng Chen, Deshi Zhao, Jingkai Xu, Chunxiao Li, Changsheng Lu, Hong Yan,* Electrooxidative B–H functionalization of nido-carboranes, Angew. Chem. Int. Ed. 60 (14) (2021), 60, 7838–7844.
14. Deshuang Tu, Hong Yan,* Jordi Poater, Miquel Solà, The nido-cage···π bond: A non-covalent interaction between boron clusters and aromatic rings and its applications, Angew. Chem. Int. Ed. 59 (23) (2020), 9018–9025.
15. Zhongming Yang, Weijia Zhao, Wei Liu, Xing Wei, Meng Chen, Xiao Zhang, Xiaolei Zhang, Yong Liang, Changsheng Lu, Hong Yan,* Metal-free oxidative B−N coupling of nido-carborane with n-heterocycles, Angew. Chem. Int. Ed. 58 (34) (2019), 11866–11892.
16. Shengyang Ni, Chun-Xiao Li, Yu Mao, Jianlin Han, Yi Wang, Hong Yan,* Yi Pan, Ni-catalyzed deaminative cross-electrophile coupling of katritzky salts with halides via C–N bond activation, Sci. Adv. 5 (6) (2019), eaaw9516.
17. Deshuang Tu, Suzhi Cai, Charlene Fernandez, Huili Ma, Xuan Wang, He Wang, Chaoqun Ma, Hong Yan,* Changsheng Lu, Zhongfu An, Boron cluster enhanced ultralong organic phosphorescence, Angew. Chem. Int. Ed. 58 (27) (2019), 9129–9133.
18. Xing Wei, Meng-Jiao Zhu, Zhe Cheng, Mengjeu Lee, Hong Yan,* Changsheng Lu, JingJuan Xu, Aggregation-induced electrochemiluminescence of carboranyl carbazoles in aqueous media, Angew. Chem. Int. Ed. 58 (10) (2019), 3162–3166.
19. Deshuang Tu, Pakkin Leong, Song Guo, Hong Yan,* Changsheng Lu, Qiang Zhao, Highly-emissive organic single-molecule white emitters by engineering o-carborane-based luminophores, Angew. Chem. Int. Ed. 56 (38) (2017), 11370–11374.
20. Xiaolei Zhang, Hongning Zheng, Jie Li, Fei Xu, Jing Zhao, and Hong Yan,* Selective catalytic B−H arylation of o‑carboanyl aldehydes by a transient directing strategy, J. Am. Chem. Soc., 139 (41) (2017), 14511–14517
21. Xiaolei Zhang, Huimin Dai, Hong Yan,* Wenli Zou, Dieter Cremer, B−H···π interactions: A new type of nonclassical hydrogen bonding, J. Am. Chem. Soc. 138 (13) (2016), 4334–4337.
22. Chao Shi, Huibin Sun, Xiao Tang, Wen Lv, Hong Yan,* Qiang Zhao, Jingxia Wang, Wei Huang, Variable photophysical properties of Iridium(III) complexes triggered by closo- and nido-carborane substitution, Angew. Chem. Int. Ed. 52 (50) (2013), 13434–13438.
23. Zhaojin Wang, Hongde Ye, Yuguang Li, Yizhi Li and Hong Yan,* Unprecedented boron-functionalized carborane derivatives by facile and selective cobalt-induced B-H activation, J. Am. Chem. Soc. 135 (30) (2013), 11289–11298.
24. Rui Zhang, Lin Zhu, Guifeng Liu, Huimin Dai, Zhenzhong Lu, Jianbo Zhao, Hong Yan,* Cobalt-promoted B-H and C-H activation: Facile B-C coupling of carboranedithiolate and cyclopentadieneyl, J. Am. Chem. Soc. 134 (25) (2012), 10341–10344.
25. Hong Yan,* Bruce C. Noll, Thomas, P. Fehlner*, Cooperative metal-boron interactions in the reaction of 1,2-nido-(Cp*RuH)2B3H7, Cp*=C5Me5 with HCCPh, J. Am. Chem. Soc. 127 (13) (2005), 4831–4844.
26. Hong Yan, Alicia M. Beatty, Thomas P. Fehlner*, Ruthenacarboranes from the reaction of nido-1,2-(Cp*RuH)2B3H7 with HCCC(O)OMe, Cp*=h5-C5Me5. Hydrometallation, alkyne incorporation and functional group modification via cooperative metal-boron interactions within a metallaborane cluster, J. Am. Chem. Soc. 125 (52) (2003), 16367–16382.
27. Hong Yan, Alicia M. Beatty, Thomas P. Fehlner*, Facile hydrometallation of alkynes by nido-1,2-(Cp*RH)2B3H7 yielding novel Ru-B edge-bridging carbenes. Stepwise conversion of HCCC(O)OMe into nido-1,2-(Cp*RH)2-3-HOB-4-MeC-5-MeOC-BH3, Cp*=C5Me5, J. Am. Chem. Soc. 124 (35) (2022), 10280–10281.
28. Hong Yan, Alicia M. Beatty, Thomas P. Fehlner*, Reaction of 2-butyne with nido-1,2-(Cp*RuH)2B3H7. Improved kinetic control leads to metallacarboranes of novel composition and structure, Angew. Chem. Int. Ed. 41 (14) (2002), 2578–2581.
29. Hong Yan, Alicia M. Beatty, Thomas P. Fehlner*, Reactivity of dimetallapentaboranes, nido-Cp*2M2B3H7, with alkynes. Insertion to form a ruthenacarborane(M=RuH) vs catalytic cyclotrimerization to form arenes(M=Rh), Angew. Chem. Int. Ed. 40 (23) (2001), 4498–4500.
30. Max Herberhold*, Hong Yan, Wolfgang Milius, Bernd Wrackmeyer, Rhodium-induced selective B(3)/B(6)-disubstitution of ortho-carborane-1,2-dithiolate, Angew. Chem. Int. Ed. 38 (24) (1999), 3689–3691.

*以上信息由高级会员个人更新和维护。