巢晖

男， 中山大学化学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

学士（1988-1992）：湘潭师范学院（现湖南科技大学）化学系
硕士（1994-1997）：南开大学化学学院
博士（1997-2000）：中山大学化学与化学工程学院
访问学者 (2000-2003)：香港科技大学化学系
博士后（2004-2005）：美国Texas A&M大学化学系
讲师（2000-2002）：中山大学化学与化学工程学院
副教授（2002-2007）：中山大学化学与化学工程学院
教授（2007-2016）：中山大学化学与化学工程学院
教授（2016-至今）：中山大学化学学院

研究领域和兴趣

化学生物学、无机化学

主要业绩

国家杰出青年科学基金获得者（2015），入选教育部“新世纪优秀人才支持计划”（2006）和广东特支计划“百千万工程领军人才”（2015）。主要从事基于金属配合物的生物荧光探针和抗肿瘤药物研究。作为主持人承担国家自然科学基金、973计划课题、教育部、广东省科技项目等30多项。在《Chem. Soc. Rev》、《Coord. Chem. Rev》、《Nature Chemistry》、《Nat. Commun.》、《Proc. Natl, Acad. Sci. USA》、《Angew. Chem. Int. Ed.》、《Adv. Mater.》、《Biomaterials》等国际期刊发表第一作者或通讯作者SCI论文220多篇，论文被引用8000多次；申请中国发明专利17件，授权13件；参编专著、教材7部。2005年获中国化学会“青年化学奖”， 2011年获广东省科学技术奖一等奖（第二完成人），2012年被评为南粤优秀教师（广东省），2012年获国家自然科学奖二等奖（第三完成人），2014年获宝钢优秀教师奖。目前担任中国化学会化学生物学专业委员会委员、中国感光学会光化学与光生物专业委员会委员、广东省化学会常务理事、广东省化学会化学生物学专业委员会主任委员、药物化学与分子诊断教育部重点实验室（河北大学）学术委员会委员、理论有机化学与功能分子教育部重点实验室（湖南科技大学）学术委员会副主任委员、《Scientific Reports》编委、《Journal of Inorganic Biochemistry》编委。

代表成果

1. Huaiyi Huang†, Samya Banerjee† (†equal contributors), Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser*, Hui Chao*, Peter J. Sadler*, “Targeted photoredox catalysis in cancer cells”, Nat. Chem., 11 (2019) 1041-1048.
2. Johannes Karges, Shi Kuang, Federica Maschietto, Olivier Blacque, Ilaria Ciofini, Hui Chao*, Gilles Gasser*, “Rationally Designed Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy”, Nat. Commun., 11 (2020) 3262.
3. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Juanjuan Huang, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for two-photon photodynamic therapy”, Proc. Natl, Acad. Sci. USA, 116 (2019) 20296-20302.
4. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”, Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
5. Xianbo Wu, Jinzhe Liang, Jun Shu, Zeqi Li, Tiantian Yin, Xiting Zhang*, Hui Chao*, “Narrow-Bandgap Iridium(III)-C3N5 Nanocomplex as Oxygen Self-Sufficient Piezo-Sonosensitizers for Hypoxic Tumor Sonodynamic Immunotherapy“, J. Am. Chem. Soc., 147 (2025) 15329-15343.
6. Ling Wang†, Lingtan Kong†, Ding-Qi Zhang† (†equal contributors), Liuqi Ye, Sang-cuo Nao, Daniel Shiu-Hin Chan, Xueying Li, Yutong Peng, Lijun Yang, Chun-Yuen Wong, Vincent Kam Wai Wong*, Wanhe Wang*, Hui Chao*, Chung-Hang Leung*, “Inhibiting glycolysis and disrupting the mitochondrial HK2-VDAC1 protein-protein interaction using a bifunctional lonidamine-conjugated metal probe for combating triple-negative breast cancer”, J. Am. Chem. Soc., 147 (2025) 14824-14836).
7. Shi Kuang†, Fangmian Wei† (†equal contributors), Johannes Karges, Libing Ke, Kai Xiong, Xinxing Liao, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Photo-Decaging of A Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia”, J. Am. Chem. Soc., 144 (2022) 4091−4101.
8. Ying Zhou†, Kai Xiong† (†equal contributors), Tao Feng, Xianbo Wu, Jinzhe Liang*, Yu Chen*, Hui Chao*, “A Nucleus-Targeting Ruthenium(II) Complex Induces DNA Condensation in Cisplatin-Resistant Tumor Cells”, Angew. Chem. Int. Ed., 64 (2025) e202504970.
9. Jinrong Yang, Fa Wang, Shuqi Huang, Tao Feng, Kai Xiong, Yu Chen*, Hui Chao*, “A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno- and Chemo-Immunotherapy in Cisplatin-Resistant Tumor Cells”, Angew. Chem. Int. Ed., 64 (2025) e202505689.
10. Tao Feng, Zixin Tang, Jun Shu, Xianbo Wu, Hui Jiang, Zhuoli Chen, Yu Chen, Liangnian Ji, Hui Chao*, “A Cyclometalated Ruthenium(II) Complex Induces Oncosis for Synergistic Activation of Innate and Adaptive Immunity”, Angew. Chem. Int. Ed., 63 (2024) e202405679.
11. Shi Kuang, Biyue Zhu, Jing Zhang, Fan Yang, Bo Wu, Weihua Ding, Liuyue Yang, Shiqian Shen, Seven H Liang, Prasenjit Mondal, Mohanraja Kumar, Rudolph E. Tanzi, Can Zhang, Hui Chao*, Chongzhao Ran*, “A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Treatment of Alzheimer's Disease”, Angew. Chem. Int. Ed., 62 (2023) e202312519.
12. Asma Mani†, Tao Feng†, Albert Gandioso†, Robin Vinck† (†equal contributors), Anna Notaro, Lisa Gourdon, Pierre Burckel, Bruno Saubaméa, Olivier Blacque, Kevin Cariou, Jamel-Eddine Belgaied, Hui Chao,* Gilles Gasser,* “Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared”, Angew. Chem. Int. Ed., 62 (2023) e202218347.
13. Kai Xiong†, Cheng Ouyang† (†equal contributors), Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Chiral RuII-PtII Complexes Inducing Telomere Dysfunction against Cisplatin-Resistant Cancer Cells”, Angew. Chem. Int. Ed., 61 (2022) e202204866.
14. Libing Ke†, Fangmian Wei† (†equal contributors), Lina Xie, Johannes Karges, Yu Chen, Liangnian Ji, Hui Chao*, “A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two-Photon Photodynamic Therapy using an Apoptosis-Ferroptosis Hybrid Pathway”, Angew. Chem. Int. Ed., 61 (2022) e202205429. (Hot Paper)
15. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao*, Ye Zhang*, “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking”, Angew. Chem. Int. Ed., 60 (2021) 7597-7601.
16. Lili Wang, Ruilin Guan, Lina Xie, Xinxing Liao, Kai Xiong, Thomas W. Rees, Yu Chen, Liangnian Ji, Hui Chao*, “An ER-Targeting Iridium(III) Complex which Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer”, Angew. Chem. Int. Ed., 60 (2021) 4657-4665. (VIP Article)
17. Cheng Ouyang, Yongguang Li, Thomas W. Rees, Xinxing Liao, Jianhua Jia, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “Supramolecular Assembly of An Organoplatinum(II) Complex with Ratiometric Dual Emission for Two-Photon Bioimaging”, Angew. Chem. Int. Ed., 60 (2021) 4150-4157.
18. Shi Kuang†, Lingli Sun† (†equal contributors), Xianrui Zhang, XinXing Liao, Thomas W. Rees, Leli Zeng, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals against Hypoxic Tumors”, Angew. Chem. Int. Ed., 59 (2020) 20697-20703.
19. Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W. Rees, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II”, Angew. Chem. Int. Ed., 59 (2020) 16631-16637. (Hot Paper)
20. Chengzhi Jin†, Fengyin Liang† (†equal contributors), Jinquan Wang, Lili Wang, Jiangping Liu, Xinxing Liao, Thomas W. Rees, Bo Yuan, Hui Wang, Yong Shen*, Zhong Pei*, Liangnian Ji, Hui Chao*, “Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging”, Angew. Chem. Int. Ed., 59 (2020) 15987-15991. (Hot Paper)
21. Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W. Rees, Ruilin Guan, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, “FerriIridium: A Lysosome-Targeting Iridium(III) Prodrug for Iron(III)-Activated Chemotherapy in Gastric Cancer Cells”, Angew. Chem. Int. Ed., 59 (2020) 3315-3321. (VIP Article)
22. Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao*, Gilles Gasser*, “Polymeric encapsulation of novel homoleptic bis(dipyrrinato) zinc(II) complexes with long lifetimes for applications as photodynamic therapy photosensitisers”, Angew. Chem. Int Ed., 58 (2019) 14334-14340.
23. Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells", Angew. Chem. Int. Ed., 56 (2017) 14898-14902. (VIP Article, Inside front cover)
24. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser*, Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”, Angew. Chem. Int. Ed., 54 (2015) 14049-14052. (VIP Article)
25. Jia Li, Leli Zeng*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*, “Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers”, Adv. Mater., 34 (2022) 2100245.

*以上信息由高级会员个人更新和维护。