崔华

女， 中国科学技术大学化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1979.09-1983.07, 成都地质学院二系岩矿分析专业， 工学学士
1983.09-1987.02 中国科学技术大学应用化学系，理学硕士（分析化学）
1987.03-1990.03 中国科学技术大学应用化学系，理学博士（分析化学）
1990.04-1993.11 中国科技大学应用化学系讲师
1993.12-1995.01 荷兰Utrecht大学博士后
1995.02-1999.09 中国科学技术大学化学系副教授
1999.09-2000.09 美国杰克逊州立大学访问学者
2000.10-现在 中国科学技术大学化学系教授、博士生导师

研究领域和兴趣

纳米化学发光及其在生物分析中的应用研究

主要业绩

近年来，主要从事纳米化学发光及其在生物分析中的应用研究，取得一系列创新性成果。发现电致化学发光的多通道发射现象，开辟了电位分辨电致化学发光这一新的研究领域；发现金属纳米粒子可作为能量接受体、微尺度反应平台、还原剂、催化剂等诱导液相化学发光与电化学发光，开拓了金属纳米化学发光与电化学发光新领域；发明了发光试剂功能化纳米材料的“直接合成法”，率先合成化学发光试剂/催化剂双功能化新型纳米材料，发现其具有优异的异相化学发光催化特性，发展了针对急性心肌梗死相关的蛋白质标志物的高灵敏度无标记纳米化学发光与电化学发光分析新方法，在急性心肌梗死快速诊断中具有重要的应用前景；研制了化学发光显微成像系统，在国际上首次成功获得了单个化学发光磁性微球的化学发光图像与动力学曲线，探索了功能化磁性微球在单粒子水平上的构效关系，并成功指导了功能化材料的优化，提高了其分析性能。已在Nature Commun.、Chemical Science、ACS Nano、Anal. Chem.、Chem. Eur. J、Chem. Commun. J. Phys. Chem. B/C、J. Mater. Chem.、Phys. Chem. Chem. Phys.等国际重要化学期刊上发表论文140余篇，获授权中国专利5项、欧洲专利1项、美国专利1项。相关工作受到国际国内同行的重要关注，2006年获国家自然科学基金委“国家杰出青年基金”， 2012年获中国化学会“分析化学基础研究梁树权奖”，2013年获“中国科学院第四届十大杰出妇女”称号，2015年获得中国化学会分析化学专业委员会“中国女分析化学家奖”，2016年担任科技部国家重点研发计划“纳米科技”重点专项项目首席科学家，2017起年任国际生物发光与化学发光理事会理事。另外，目前还担任中国仪器仪表学会分析仪器分会电化学分析专业委员会委员、中国生物检测监测产业技术创新战略联盟副理事长、《Anal. Bioanal. Chem.》编辑以及《Anal. Chem.》、《ACS sensor》和《分析化学》等杂志编委。受邀在法国、瑞典召开的16th & 18th International Symposium on Bioluminescence & Chemiluminescence和在法国召开的2nd International Meeting on Electrogenerated Chemiluminescence作大会特邀报告。

代表成果

1. Wei Nie, Ruoxian Zhang, Chao Hu, Tengchuan Jin, Xi Wei*, Hua Cui*, “A self-enhanced electrochemiluminescence array chip for portable label-free detection of SARS-CoV-2 nucleocapsid protein with smartphone", Biosensors and Bioelectronics., 240 (2023) 115662.
2. Manli Wang, Jiangnan Shu*, Shanshan Wang, Aihua Lyu, Yisha Wang, Dabing Huang, and Hua Cui*, “N-(4-Aminobutyl)-N-ethylisopropanol and Co2+ Dual-Functionalized Core–Shell Fe3O4@Au/Ag Magnetic Nanomaterials with Strong and Stable Chemiluminescence for a Label-Free Exosome Immunosensor", Anal.Chem., 2023, 95, 34, 12982–12991.
3 . Shanshan Wang, Fajin Qu, Ruoxian Zhang, Tengchuan Jin, Tianhua Zheng, Jiangnan Shu, and Hua Cui*, “Emission Onset Time-Adjustable Chemiluminescent Gold Nanoparticles with Ultrastrong Emission for Smartphone-Based Immunoassay of Severe Acute Respiratory Syndrome Coronavirus 2 Antigen”, Anal. Chem., 2023, 95, 33, 12497–12504.
4. Aihua Lyu, Yisha Wang, and Hua Cui*, “Enhanced Chemiluminescence under the Nanoconfinement of Covalent–Organic Frameworks and Its Application in Sensitive Detection of Cancer Biomarkers”, Anal. Chem., 2023, 95, 20, 7914–7923.
5. Dexin Du, Jue Wang, Mingquan Guo, Jiangnan Shu, Wei Nie, Zhiping Bian, Di Yang, and Hua Cui*, “Charge-dependent signal changes for label-free electrochemiluminescence immunoassays”, Anal. Chem., 2022, 94(47), 16436–16442
6. Tianhua Zheng, Wei Nie, Lu Yu, Jiangnan Shu, Yaohua Li, Changlin Tian, Wei Wang, and Hua Cui*, "A chemical timer approach to delayed chemiluminescence", Proc. Natl. Acad. Sci. U.S.A., 2022, 119 (43), e2207693119.
7. Jue Wang, Chao Hu, Yi-sha Wang, and Hua Cui*, "Chemiluminescent Two-Dimensional Metal–Organic Framework with Multiple Metal Catalytic Centers and Its Peroxidase-like Activity for Sensing of Small Molecules", ACS Appl. Mater. Interfaces., 2022, 14, 2, 3156-3164.
8. Shanshan Wang, Jiangnan Shu, Aihua Lyu, Xiaoxue Huang, Weihong Zeng, Tengchuan Jin, and Hua Cui*, "Label-Free Immunoassay for Sensitive and Rapid Detection of the SARS-CoV-2 Antigen Based on Functionalized Magnetic Nanobeads with Chemiluminescence and Immunoactivity", Anal. Chem., 2021, 93, 14238–14246.
9. Fang Li, Yating Liu, Zimu Li, Qi Li, Xiaoying Liu, and Hua Cui*, "Cu(II)-Regulated On-Site Assembly of Highly Chemiluminescent Multifunctionalized Carbon Nanotubes for Inorganic Pyrophosphatase Activity Determination", ACS Appl. Mater. Interfaces., 2020, 12, 2, 2903–2909.
10. Weijun Kong, Qi Li, Wei Wang, Xiaoning Zhao, Shenglong Jiang, Tianhua Zheng, Qun Zhang, Wen Shen, and Hua Cui*, "Rational design of functional materials guided by single particle chemiluminescence imaging", Chem. Sci., 2019, 10, 5444.
11. Rui Yang, Fang Li, Wencan Zhang, Wen Shen, Di Yang, Zhiping Bian, and Hua Cui*, "Chemiluminescence immunoassays for simultaneous Detection of three heart-disease biomarkers using magnetic carbon composites and three-dimensional microfluidic paper-based device", Anal. Chem., 2019, 91, 20, 13006–13013.
12. Zhili Han, Jiangnan Shu,Qiaoshi Jiang, and Hua Cui*, "Coreactant-free and label-free electrochemiluminescence immunosensor for copeptin based on luminescent immuno-gold nanoassemblies", Anal. Chem., 2018, 90, 10, 6064-6070.
13. Yao Huang, Lingfeng Gao, and Hua Cui*, "Assembly of Multifunctionalized Gold Nanoparticles with Chemiluminescent, Catalytic, and Immune Activity for Label-Free Immunoassays", ACS Appl. Mater. Interfaces., 10, 20, 17040-17046.
14. Yating Liu, Wen Shen, Qi Li, Jiangnan Shu, Lingfeng Gao, Mingming Ma, Wei Wang and Hua Cui*, "Firefly-mimicking intensive and long-lasting chemiluminescence hydrogels". Nature Commun., 2017, 8:1003.
15. Jiangnan Shu, Zhili Han, Tianhua Zheng, Dexin Du, Guizheng Zou, and Hua Cui*, "Potential-Resolved Multicolor Electrochemiluminescence of N-(4-Aminobutyl)-N-ethylisoluminol/tetra(4-carboxyphenyl)porphyrin/TiO2 Nanoluminophores". Anal. Chem., 2017, 89, 23, 12636-12640.
1. 崔华; 郑天骅; 聂威 ; 一种化学发光组合物和调节化学发光的方法, 2021.6.29, 中国,202110725653.6.
2. 崔华; 刘雅婷; 沈雯 ; 双功能化水凝胶聚合物复合材料、其制备方法和用途, 2021.6.8, 日本, 特愿2019-532772.
3. Hua Cui; Dayong Tian; Luminescent gold nanomaterial functionalized by N-(4-aminobutyl)-N-ethylisoluminol,preparation and application thereof, 2016.8.9, 美国, US 9410950B2.

*以上信息由高级会员个人更新和维护。