黎占亭

男， 中国科学院上海有机化学研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1981.09-1985.06：郑州大学化学系本科生
1985.-6-1987.07：原河南医科大学基础部化学教研室助教
1987.08-1990.06：中科院上海有机化学研究所硕士生
1990.07-1992.12：中科院上海有机化学研究所博士生
1993.03-1996.08：中科院上海有机化学研究所助理研究员
1994.10-1995.12：South University of Denmark化学系博士后
1996.09-2001.12：中科院上海有机化学研究所副研究员
1999.10-2000.12：美国University of Illinois at Urbana-Champaign化学系访问学者
2002.01-2010.04：中科院上海有机化学研究所研究员
2010.05-2024.03：复旦大学化学系教授
2024:04至今：中科院上海有机化学研究所研究员

研究领域和兴趣

超分子化学，有机生物材料

主要业绩

1. 创建了水溶性超分子有机框架
2. 创建了水溶性柔性有机框架
3. 建立了有机分子内氟原子为受体的稳定氢键模式

代表成果

1. 代表性论文：
(1) Jingyu Yang，Yan Wu，Yue-Yang Liu，Shang-Bo Yu，Ke Feng，Hui Wang，Wei Zhou，Da Ma，Gang Zhao，Jiaheng Zhang，Dan-Wei Zhang，Zhan-Ting Li. Discovery of an Ultralong-acting Nondepolarizing Neuromuscular Blocker That Displays Short Onset Time and On-Demand Rapid Reversal by a Biocompatible Antagonist. Journal of Medicinal Chemistry, 68 (7) (2025), 7031-7043.
(2) Ke Feng，Yue-Yang Liu，Yang Zong，Zhuo Lei，Yan Wu，Jingyu Yang，Furong Lin，Qiao-Yan Qi，Qian Li，Sheng-Yi Zhuang，Jiangshan Zhang，Jia Tian，Wei Zhou，Da Ma，Dan-Wei Zhang，Zhan-Ting Li，Shang-Bo Yu. Structure−Activity Relationship Studies Leading to the Discovery of Highly Water-Soluble and Biocompatible Acyclic Cucurbit[n]uril FY- 3451 as a Universal Antagonist That Rapidly Reverses Neuromuscular Blocking Agents In Vivo. Journal of Medicinal Chemistry, 67 (17) (2024), 17905-17918.
(3) Yan Wu, Jingyu Yang, Sheng-Yi Zhuang, Shang-Bo Yu, Yang Zong, Yue-Yang Liu, Gang Wu, Qiao-Yan Qi, Hui Wang, Jia Tian, Wei Zhou, Da Ma, Dan-Wei Zhang, and Zhan-Ting Li. Macrocycles and Acyclic Cucurbit[n]urils as Pseudo[2]catenane Partners for Long-Acting Neuromuscular Blocks and Rapid Reversal In Vivo. Journal of Medical Chemistry, 67 (3) (2024), 2176-2187.
(4) Yang Zong, Zhuo Lei, Shang-Bo Yu, Ling-Yu Zhang, Yan Wu, Ke Feng, Qiao-Yan Qi, Yamin Liu, Yajie Zhu, Peng Guo, Wei Zhou, Dan-Wei Zhang, and Zhan-Ting Li. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo. Journal of Medical Chemistry, 67 (5) (2024), 3860-3873.
(5) Zhan-Ting Li, Shang-Bo Yu, Yamin Liu, Jia Tian, and Dan-Wei Zhang. Supramolecular Organic Frameworks: Exploring Water-Soluble, Regular Nanopores for Biomedical Applications. Account of Chemical Research, 2022, 55 (16) (2022), 2316-2325.
(6) Hong-Kun Liu，Furong Lin，Shang-Bo Yu，Yan Wu，Shuai Lu，Yue-Yang Liu，Qiao-Yan Qi，Jin Cao，Wei Zhou，Xiaopeng Li，Hui Wang，Dan-Wei Zhang，Zhan-Ting Li，Da Ma. Highly Water-Soluble Cucurbit[8]uril Derivative as a Broad- Spectrum Neuromuscular Block Reversal Agent. Journal of Medicinal Chemistry, 65 (24) (2022), 16893-16901.
(7) Furong Lin，Shang-Bo Yu，Yue-Yang Liu，Chuan-Zhi Liu，Shuai Lu，Jin Cao，Qiao-Yan Qi，Wei Zhou，Xiaopeng Li，Yi Liu，Jia Tian，Zhan-Ting Li. Porous Polymers as Universal Reversal Agents for Heparin Anticoagulants through an Inclusion–Sequestration Mechanism. Advanced Materials, 34 (23) (2022), 2200549.
(8) Yamin Liu，Chuan-Zhi Liu，Ze-Kun Wang，Wei Zhou，Hui Wang，Yun-Chang Zhang，Dan-Wei Zhang，Da Ma，Zhan-Ting Li. Supramolecular organic frameworks improve the safety of clinically used porphyrin photodynamic agents and maintain their antitumor efficacy. Biomaterials, 284 (2022), 121467.
(9) Jia-Le Lin, Ze-Kun Wang, Zi-Yue Xu, Lei Wei, Yun-Chang Zhang, Hui Wang, Dan-Wei Zhang, Wei Zhou, Y.-B. Zhang, Yi Liu, Zhan-Ting Li, Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins. Journal of the American Chemical Society 142 (7) (2020), 3577-3582.
(10) Bo Yang，Xiao-Dan Zhang，Jian Li，Jia Tian，Yi-Peng Wu，Fa-Xing Yu，Ruibing Wang，Hui Wang，Dan-Wei Zhang，Yi Liu，Lu Zhou，Zhan-Ting Li. In Situ Loading and Delivery of Short Single- and Double-Stranded DNA by Supramolecular Organic Frameworks. CCS Chemistry, 1 (2) (2019), 156-165.
(11) Jia Tian，Chi Yao，Wen-Lin Yang，Lei Zhang，Dan-Wei Zhang，Hui Wang，Fan Zhang，Yi Liu，Zhan-Ting Li. In situ-prepared homogeneous supramolecular organic framework drug delivery systems (sof-DDSs): Overcoming cancer multidrug resistance and controlled release, Chinese Chemical Letters, 28 (4) (2017), 798-806.
(12) Jia Tian, Hui Wang, Dan-Wei Zhang, Yi Liu, Zhan-Ting Li, Supramolecular Organic frameworks (SOFs): homogeneous regular 2D and 3D pores in water. National Science Review, 4 (3) (2017), 426-436.
(13) Dan-Wei Zhang, Xin Zhao, Zhan-Ting Li, Aromatic Amide and Hydrazide Foldamer-Based Responsive Host−Guest Systems. Account of Chemical Research, 2014, 47 (7) (2014), 1961-1970.
(14) Jia Tian，Tian-You Zhou，Shao-Chen Zhang，Shaul Aloni，Maria Virginia Altoe，Song-Hai Xie，Hui Wang，Dan-Wei Zhang，Xin Zhao，Yi Liu，Zhan-Ting Li. Three-dimensional periodic supramolecular organic framework ion sponge in water and microcrystals. Nature Communications, 5 (2014), 5574-5574.
(15) Kang-Da Zhang, Jia Tian, D. Hanifi, Y. Zhang, A. C.-H. Sue, T.-Y. Zhou, L. Zhang, X. Zhao, Y. Liu,* Z.-T. Li,* Toward a Single-Layer Two-Dimensional Honeycomb Supramolecular Organic Framework in Water. Journal of the American Chemical Society 135 (47) (2013), 17913-17918.
(16) Zhan-Ting Li, Jun-Li Hou, Chuang Li, Peptide Mimics by Linear Arylamides: A Structural and Functional Diversity Test. Account of Chemical Research, 41 (10) (2008), 1343-1353.
(17) Chuang Li，Shi-Fang Ren，Jun-Li Hou，Hui-Ping Yi，Shi-Zheng Zhu，Xi-Kui Jiang，Zhan-Ting Li. F···HN Hydrogen Bonding Driven Foldamers: Efficient Receptors for Dialkylammonium Ions. Angewandte Chemie International Edition. 44 (35) (2005), 5725-5729.
(18) Jun-Li Hou，Xue-Bin Shao，Guang-Ju Chen，Yan-Xia Zhou，Xi-Kui Jiang，Zhan-Ting Li. Hydrogen Bonded Oligohydrazide Foldamers and Their Recognition for Saccharides. Journal of the American Chemical Society, 126 (39) (2004), 12386-12394.

2. 发明专利
(1) 黎占亭，张丹维，孙健达，王辉，刘亚敏；正离子型环蕃及其在制备清除光动力治疗残留物的药物制剂中的应用；申请年份：2022；申请号：202210970847.7；授权年份：2023；专利号：ZL 2022 1 0970847.7。
(2) 黎占亭，刘月阳，张丹维，周伟，王辉，王泽坤，余尚博；水溶性正离子型超分子有机框架共价纳米仿生给药系统；申请年份：2022；申请号：202210345116 .3；授权年份：2023；专利号：ZL 2022 1 0345116.3。
(3) 黎占亭，张丹维，刘亚敏，王辉，王泽坤；专利名称：正离子超分子有机框架固体材料在吸附生物毒素中的应用；申请年份：2021；申请号：202111593046 .5；授权年份：2023；专利号：ZL 2021 1 1593046.5。
(4) 黎占亭，张丹维，刘鸿琨，王辉，周伟，马达；水溶性葫芦[8]脲磺酸盐衍生物及其制备方法和应用；申请年份：2021；申请号：202110846340 .6；授权年份：2022；专利号：ZL 2021 1 0846340.6。
(5) 黎占亭，张丹维，刘亚敏，刘传志，马达，周伟，王辉；超分子有机框架材料在清除光动力治疗残留药物中的应用；申请年份：2021；申请号：202110745896 .6；授权年份：2023；专利号：ZL 2021 1 0745896.6。
(6) 黎占亭，张丹维，王辉，周伟，林佳乐，张运昌，王泽坤；一种水溶性正离子型有机多孔聚合物及其制备方法和应用；申请年份：2019；申请号：201910819721 .8；授权年份：2022；专利号：ZL 2019 1 0819721.8。

3. 著作
(1) 黎占亭，张丹维编著，《氢键: 分子识别与自组装》， 化学工业出版社，2017，北京。
(2) Zhan-Ting Li, Li-Zhu Wu,《Hydrogen Bonded Supramolecular Structures》， Springer, 2015, New York.
(3) Zhan-Ting Li, Li-Zhu Wu, 《Hydrogen Bonded Supramolecular Materials》， Springer, 2015, New York.

*以上信息由高级会员个人更新和维护。