黄瑾

女， 华东理工大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1993.9-1997.6 四川大学生物学，本科学生
1997.8-1998.8 广西师范大学化学学院，实验员
1998.9-2001.6 广西师范大学化学学院，硕士研究生
2001.9-2004.6 南京大学化学化工学院，博士研究生
2004.9-2006.6 美国St. Jude Chilaren's Research Hospital 机构生物学系, 博士后
2006.8-2011.12 华东理工大学药学院，副教授，硕士生导师
2012.1-2013.8 华东理工大学药学院，副教授，博士生导师
2013.8-至今 华东理工大学药学院，教授，博士生导师

研究领域和兴趣

化学生物学

主要业绩

主讲本科生《药物化学生物学》课程，课程分别入选上海市重点课程、校级本科教育教学改革重点建设项目、在线课程建设项目等，在中文核心《实验室科学》及专业领域《药学教育》等期刊发表教改论文数篇。
从疾病状态下的“靶标微环境”特征出发，构建基于病理条件下靶标“优势态”的分子-细胞-动物测试体系，深入研究药靶调控新功能，针对蛋白降解及疾病演进过程中的关键特征构建动态监测体系，利用课题组高效药物发现技术与化学家合作发现多种结构类型的新药物候选物。研究成果相继发表于Angew. Chem. Int. Ed.、Haematologica、Oncogene、J. Med. Chem.等本领域高影响期刊。
课题组培养的多名博士、硕士研究生曾获国家奖学金、上海市优秀毕业生、中国药理学会青年药理学家奖等荣誉称号。

代表成果

1、Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu*, Jin Huang*. Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochemical Pharmacology, 2020 Jul;177:114000
2、Xueyuan Wu, Mingbo Wang, Yaqian Wang, Mengyin Li, Yilun Ying, Jin Huang*, Yitao Long*. Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single-Molecule Sensing. CCS Chemistry. 2019 Aug; 1(3): 81-89.
3、Zhonghong Zhu, Qian Hu, Huiling Pan, Yuexing Zhang, Haibing Xu, Mohamedally Kurmoo, Jin Huang*, Ming-Hua Zeng*. Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer. Science China-chemistry. 2019 Jun, 62(6): 719-726.
4、Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018 Sep, 103(9): 1472-1483.
5、Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*.Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017, Aug 17, 36(33): 4719-4731.
6、Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*, Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. Journal of Medicinal Chemistry. 2017 Mar 9; 60(5): 1817-1828.
7、Zengrui Wu, Weiqiang Lu, Dang Wu, Anqi Luo, Hanping Bian, Jie Li, Weihua Li, Guixia Liu, Jin Huang*, Feixiong Cheng*, Yun Tang*. In silico prediction of chemical mechanism-of-action via an improved network-based inference method. British Journal of Pharmacology. 2016 Sep 20;173:3372-3385.
8、Minghua Zeng*, Zheng Yin, Zehui Liu, Haibing Xu, Yingchun Feng, Yueqiao Hu, Lixian Chang, Yuexing Zhang, Jin Huang*, Mohamedally Kurmoo. Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging. Angewandte Chemie International Edition. 2016 Sep 12; 55(38): 11407-11411.

*以上信息由高级会员个人更新和维护。