刘心元

男， 南方科技大学、化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1997.09-2001.06，安徽师范大学化学系，本科学生
2001.09-2004.06，上海有机所和安徽师范大学联合培养化学系，研究生
2004.07-2005.08，中国科学院上海有机化学研究所，助理研究员
2006.09-2010.03，香港大学化学系，博士生
2010.04-2012.08，美国斯克利普斯研究所和香港大学化学系，博士后
2012.09-2017.12，南方科技大学化学系，副教授
2018.01-至今，南方科技大学化学系，终身教授
2022.11-至今，南方科技大学化学系，讲席教授

研究领域和兴趣

自由基参与的不对称反应

主要业绩

不对称自由基催化化学作为催化化学的一个重要分支，是高效合成手性化合物的重要工具之一。刘心元教授围绕“不对称自由基催化化学”这一科学难题开展了深入系统的研究，提出了独具特色的“手性阴离子／金属单电子催化剂”新策略，发展了多样性的不对称自由基反应，如烷烃碳氢不对称官能化、烯烃双官能化、卤代烃的交叉偶联以及去对称化等反应。以通讯作者身份在Nat. Chem. (1)、Nat. Catal. (2)、Acc. Chem. Res. (1)、Chem (2)、J. Am. Chem. Soc. (5)、Angew. Chem. Int. Ed. (15)、Nat. Commun. (5)、Chem. Soc. Rev. (1)等期刊上共发表论文70多篇；申请专利8项。作为主持人承担10多项国家以及省市项目。最近受Nat. Commun.、ACS Catal.、Wiley和Chem. Soc. Rev.等编辑部邀请撰写研究领域展望、编辑不对称自由基化学书籍及专刊，并受邀担任Chem. Soc. Rev.客座编辑。曾获“国家自然科学基金优秀青年基金”、“教育部长江学者奖励计划-青年学者项目”、“中美华人化学与化学生物学教授联合会杰出教授奖”、“日本化学会杰出讲席奖”、“亚洲核心计划讲座奖”“南科大优秀和（校长）青年科研奖”等奖项或资助。本人2019年4月份于南科大组织承办了中国化学会第二届全国有机自由基化学会议。刚刚入围“2020年度国家杰出青年科学基金建议资助项目申请人名单”。

代表成果

1. Yu-Feng Zhang,+ Biao Wang,+ Zheng Chen,+ Ji-Ren Liu,+ Ning-Yuan Yang, Jin-Min Xiang, Juan Liu, Qiang-Shuai Gu, Xin Hong,* Xin-Yuan Liu*, Asymmetric amination of alkyl radicals with two minimally different alkyl substituents, Science, 388, 2025, 283-291.
2. Ji-Jun Chen, Jia-Heng Fang, Xuan-Yi Du, Jia-Yong Zhang, Jun-Qian Bian, Fu-Li Wang, Cheng Luan, Wei-Long Liu, Ji-Ren Liu, Xiao-Yang Dong, Zhong-Liang Li, Qiang-Shuai Gu, Zhe Dong, and Xin-Yuan Liu*, Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines, Nature, 618, 2023, 294-300.
3. Xiao-Yang Dong, Yu-Feng Zhang, Can-Liang Ma, Qiang-Shuai Gu, Fu-Li Wang, Zhong-Liang Li, Sheng-Peng Jiang, and Xin-Yuan Liu*, A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling, Nature Chemistry, 11, 2019, 1158-1166.
4. Fu-Li Wang, Chang-Jiang Yang, Ji-Ren Liu, Ning-Yuan Yang, Xiao-Yang Dong , Ruo-Qi Jiang, Xiao-Yong Chang , Zhong-Liang Li, Guo-Xiong Xu, Dai-Lei Yuan, Yu-Shuai Zhang, Qiang-Shuai Gu ,* Xin Hong *, and Xin-Yuan Liu *, Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes, Nature Chemistry, 14, 2022, 949-957.
5. Yong-Feng Cheng, Zhang-Long Yu, Yu Tian, Ji-Ren Liu, Han-Tao Wen, Na-Chuan Jiang, Jun-Qian Bian, Guo-Xiong Xu, Dan-Tong Xu, Zhong-Liang Li, Qiang-Shuai Gu ,* Xin Hong *, and Xin-Yuan Liu *, Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling, Nature Chemistry, 15, 2023, 395-404.
6. Yu Tian, Xi-Tao Li, Ji-Ren Liu, Jian Cheng, Ang Gao, Ning-Yuan Yang, Zhuang Li, Kai-Xin Guo, Wei Zhang, Han-Tao Wen, Zhong-Liang Li, Qiang-Shuai Gu, Xin Hong, and Xin-Yuan Liu*, A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution, Nature Chemistry, 16, 2024, 466-475.
7. Li-Wen Fan,+ Jun-Bin Tang,+ Li-Lei Wang,+ Zeng Gao,+ Ji-Ren Liu,+ Yu-Shuai Zhang, Dai-Lei Yuan, Li Qin, Yu Tian, Zhi-Chao Chen, Fu Liu, Jin-Min Xiang, Pei-Jie Huang, Wei-Long Liu, Chen-Yu Xiao, Cheng Luan, Zhong-Liang Li, Xin Hong*, Zhe Dong*, Qiang-Shuai Gu*, Xin-Yuan Liu*, Copper-catalysed asymmetric cross-coupling reactions tolerant of highly reactive radicals, Nature Chemistry, 2025, doi.org/10.1038/s41557-025-01970-1.
8. Chang-Jiang Yang, Chi Zhang, Qiang-Shuai Gu, Jia-Heng Fang, Xiao-Long Su, Liu Ye, Yan Sun, Yu Tian, Zhong-Liang Li, and Xin-Yuan Liu*, Cu-catalysed intramolecular radical enantioconvergent tertiary β-C(sp3)–H amination of racemic ketones, Nature Catalysis, 3, 2020, 539-546.
9. Jia-Yong Zhang,+ Ji-Jun Chen,+ Boming Shen,+ Jia-Heng Fang, Xuan-Yi Du, Ning-Yuan Yang, Chang-Jiang Yang, Wei-Long Liu, Fu Liu, Zhong-Liang Li, Qiang-Shuai Gu, Zhe Dong, Peiyuan Yu* & Xin-Yuan Liu*, Copper-catalysed enantioconvergent O-alkylation of alcohols with racemic α-tertiary haloamides to access enantioenriched hindered dialkyl ethers, Nature Catalysis, 8, 2025, 919-930.
10. Jia-Heng Fang, Ji-Jun Chen, Xuan-Yi Du, Zhe Dong, Run-Yan Tian, Chang-Jiang Yang, Fu-Li Wang, Cheng Luan, Zhong-Liang Li, and Xin-Yuan Liu*, Copper-Catalyzed Asymmetric Three-Component Radical 1,2-Carboamination of Acrylamides with Arylamines: Access to Chiral α-Tertiary N-Arylamines, CCS Chemistry, 6, 2024, 2652-2661.

*以上信息由高级会员个人更新和维护。