冯传良

男， 上海交通大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1992.09-1996.06， 河南师范大学化学系， 本科学生
1996.07-1998.08， 新乡市第二十五中学， 化学教师
1998.09-2001.06， 河南师范大学化学系，中国科学院化学研究所， 硕士研究生（联培）
2001.12-2005.12， 荷兰特文特（Twent）大学化工系， 博士研究生
2006.01-2008.03， 德国马普高分子所， 博士后
2008.04-2009.07， 荷兰格罗宁根微纳系统（Biomade）研究所， 研究员
2009.08-2012.12， 上海交通大学材料学院， 特别研究员
2013.01-2019.06， 上海交通大学， 教授
2019.07-2021.07， 上海交通大学， 长聘教授
2021.08-至今， 上海交通大学， 特聘教授

研究领域和兴趣

超分子，生物材料，高分子，手性材料

主要业绩

秉承生命体中手性基元有序组装、再现自然手性结构精细构型、揭示其生物性能是揭秘生命体手性奥秘的基石和有效途径，也是材料和生物学领域的重大挑战。超分子组装是创制仿生手性结构最有效的方法，但其基元长程无序排列阻碍了手性特征的跨尺度传递与仿生。本项目发展了一类全新 “中心对称”手性超分子骨架体系，突破了传统超分子无法长程有序组装的瓶颈，实现了自然精细手性结构精准仿生，并率先发现了手性结构显著调控细胞命运的现象，为揭示手性的生命意义提供了新范式。重要科学发现如下：
1.提出了“对称手性传递”的超分子设计新思想。建立了“亲水-疏水-亲水”中心对称的手性超分子设计准则，发展了秉承自然手性精细构型的超分子体系。通过“分子-链增长”组装模式使分子长程有序排列，手性特征从单分子向超分子聚集体和宏观材料逐级传递，解决了传统仿生超分子因“分子-成核-再聚集”导致的结构手性“淬灭”难题。
2.揭示了手性结构精细构型的调控机制。发现手性位点的空间构象、数量和位置分布决定了分子堆积方式及组装形貌，是控制组装体手性精细结构形成的关键因素。揭示了分子间或分子内的氢键限域作用是调控组装体手性构型的核心，提出了适用于手性结构精准仿生的氢键调控策略。
3.发现了手性结构决定细胞命运的新现象。率先发现左旋结构高效促进细胞粘附生长而右旋结构抑制的高度选择性现象；率先发现手性结构是决定干细胞分化命运的重要因素之一，确立了手性结构在干细胞移植治疗中的重要地位。这为再生医学和组织工程材料的发展提供了新视角。
研究在手性结构精细构型仿生领域取得了重要进展。中心对称分子设计思想被广泛用于有机化合物手性及其他复杂精细结构的制备，手性结构决定细胞命运的发现在生物材料和细胞生物学领域取得开创性突破，推动了超分子材料、生物材料和生物学的发展。
基于上述研究，获国家“万人计划”科技创新领军人才，科技部中青年科技创新领军人才，教育部新世纪优秀人才、上海东方学者、上海浦江学者。国际高分子材料表征（Poly-Char）学术委员会委员。中国高分子专家智库委员会常务委员，中国复合材料专家委员会智库成员。主持国家自然科学基金重点项目，上海市教委创新科研计划重大项目等30余项。在Acc. Chem. Res.，Adv. Mater., J. Am. Chem. Soc., Angew. Chem. Int. Ed等顶级刊物发表SCI论文140余篇，申请与授权专利30余项。担任Advanced Fiber Materials，Supramolecular Materials，Advanced Composite and Hybrid Materials、European Polymer Journal，Gels等期刊编委。获Poly-Char2019学会RICHARD ROBERT ERNST国际学术奖，2019年中国产学研合作创新奖。发表教学论文两篇，主编英文教材一部，由SPRINGER出版并获社科基金的资助。

代表成果

1. Ya Li, Yulin Wang, Qiang Ao, Xiaohui Li, Zhongbing Huang*, Xiaoqiu Dou, Ning Mu, Ximing Pu, Juan Wang, Tunan Chen, Guangfu Yin, Hua Feng, Chuanliang Feng*. Unique Chirality Selection in Neural Cells for D-Matrix Enabling Specific Manipulation of Cell Behaviors. Adv. Mater. 2023, 35, 2301435.
2. Laiben Gao, Xiaoqiu Dou*, Chao Xing, Fengli Gao, Zichao Jiang, Kaikai Yang, Changli Zhao, Chuanliang Feng*. Realizing Abundant Chirality Inversion of Supramolecular Nanohelices by Multiply Manipulating the Binding Sites in Molecular Blocks. Angew. Chem. Int. Ed. 2023, 62, e202303812.
3. Laiben Gao, Chao Xing, Xiaoqiu Dou,* Yunqing Zou, Changli Zhao, Chuanliang Feng*. Kinetic Co-assembly Pathway Induced Chirality Inversion Along with Morphology Transition. Angew. Chem. Int. Ed. 2022, 61, e202211812.
4. Shengjie Jiang, Qiang Zeng, Kai Zhao, Jinying Liu, Qiannan Sun, Kang Huang, Ying He, Xuehui Zhang, Hui Wang, Xinghua Shi, Chuanliang Feng*, Xuliang Deng*, Yan Wei*. Chirality Bias Tissue Homeostasis by Manipulating Immunological Response. Adv. Mater. 2022, 34, 2105136.
5. Xiaoqiu Dou#, Nabila Mehwish#, Changli Zhao, Jinying Liu, Chao Xing, Chuanliang Feng*. Supramolecular Hydrogels with Tunable Chirality for Promising Biomedical Applications. Acc. Chem. Res. 2020, 53, 852−862.
6. Yan Wei, Shengjie Jiang, Mengting Si, Xuehui Zhang, Jinying Liu, Zheng Wang, Cen Cao, Jianyong Huang, Houbing Huang, Lili Chen, Shutao Wang, Chuanliang Feng*, Xuliang Deng*, Lei Jiang, Chirality controls mesenchymal stem cell lineage diversification through mechanoresponses, Adv. Mater. 2019, 31, 1900582
7. Ka Young Kim, Jaehyeong Kim, Cheol Joo Moon, Jinying Liu, Shim Sung Lee, Myong Yong Choi*, Chuanliang Feng*, Jong Hwa Jung*. Co-Assembled Supramolecular Nanostructure of Platinum(II) Complex through Helical Ribbon to Helical Tubes with Helical Inversion. Angew. Chem. Int. Ed. 2019, 58, 11709-11714.
8. Jinying Liu, Feng Yuan, Xiaoyu Ma, Auphedeous Y.Dang-i, Changli Zhao, Chuntai Liu, Changyu Shen, Chuanliang Feng*. The Cooperative Effect of both Molecular and Supramolecular Chirality on Cell Adhesion, Angew. Chem. Int. Ed., 2018, 57(22), 6475-6479.
9. Fang Wang, Chuanliang Feng*. Metal-Ion-Mediated Supramolecular Chirality of L-Phenylalanine Based Hydrogels, Angew. Chem. Int. Ed., 2018, 57(20), 5655-5659.
10. Heekyoung Choi, Kang Jin Cho, Hyowon Seo, Junho Ahn, Jinying Liu, Shim Sung Lee, Hyungjun Kim*, Chuanliang Feng*, Jong Hwa Jung*, Transfer and Dynamic Inversion of Coassembled Supramolecular Chirality through 2D-Sheet to Rolled-Up Tubular Structure, J. Am. Chem. Soc.2017, 139(49), 17711-17714.
11. Xiaoqiu Dou, Chuanliang Feng*. Amino Acids and Peptide-Based Supramolecular Hydrogels for Three-Dimensional Cell Culture, Adv. Mater. 2017, 29(16), 1604062.
12. Guo-Feng Liu, Ling-Yun Zhu, Wei Ji, Chuan-Liang Feng,* Zhi-Xiang Wei, Inversion of the Supramolecular Chirality of Nanofibrous Structures through Co-Assembly with Achiral Molecules, Angew. Chem. Int. Ed. 2016, 55(7),2411-2415.
13. Guofeng Liu, Di Zhang, Chuanliang Feng*, Control of Three-Dimensional Cell Adhesion by the Chirality of Nanofibers in Hydrogels, Angew. Chem. Int. Ed. 2014, 53(30), 7789-7793.
14. Chuanliang Feng, Xinhua Zhong, Martin Steinhart, Anne-Marie Caminade, Jean-Pierre Majoral, Wolfgang Knoll*. Graded-bandgap quantum-dot-modified nanotubes: A sensitive biosensor for enhanced detection of DNA hybridization. Adv. Mater. 2007, 19(15), 1933-1936.
15. Chuanliang Feng, Anika Embrechts, IlonaBredebusch, Juergen Schnekenburger,Wolfram Domschke, G. Julius Vancso, Holger Schonherr*. Reactive microcontact printing on block copolymer films: Exploiting chemistry in microcontacts for sub-micrometer patterning of biomolecules. Adv. Mater. 2007, 19(2), 286-290.
16. Chao Xing, Laiben Gao, Xiaoqiu Dou*, Kaikai Yang, Changli Zhao, Chuanliang Feng*. Supramolecular Chiral Nanofibers Activated Pro-Survival Autophagy: An Extracellular Strategy for Hypoxic Cell Protection. Adv. Funct. Mater. 2024, 34(8), 2310426.
17. Meng Sun, Shiqiao Peng, Changli Zhao, Juexin Huang, Jingyi Xia, Dan Ye, Xiaoqiu Dou, Wanying Hou, Chuanliang Feng*. Herb-Functionalized Chronic Wound Dressings for Enhancing Biological Functions: Multiple Flavonoids Coordination Driven Strategy. Adv. Funct. Mater. 2022, 12, 2204291.
18. Fang Wang, Huibin Qiu*, Chuanliang Feng*. Wrapping Chiral Nanoribbons into Coiled and Condensed Microstructures in Supramolecular Hydrogels. Adv. Funct. Mater. 2020, 30, 2002936.
19. Chuanliang Feng, G. Julius Vancso, Holger Schoenherr. Fabrication of robust biomolecular patterns by reactive microcontact printing on N-hydroxysuccinimide ester-containing polymer films. Adv. Funct. Mater. 2006, 16(10), 1306-1312.

*以上信息由高级会员个人更新和维护。