梅文杰

男， 广东药科大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1990.9-1993.6 湖南常德师范专科学校 化学专业
1993.7-1997.6 湖南常德南平中学 任教
1997.9-2000.6 中山大学 硕士研究生
2000.7-2003.6 中山大学 博士研究生
2003.7-2008.12 广东药学院 任教
2009.3-2012.3 暨南大学 博士后
2009.1-2014.6 广东药学院 教授
2014.7-2015.7 英国伦敦大学学院 访问学者
2015.1-至今 广东药科大学 教授
2017.10-至今 广东省分子探针与生物医学影像工程技术研究中心 主任

研究领域和兴趣

药学；化学生物学；手性化学

主要业绩

梅文杰，博士，教授，硕士研究生导师。曾主持国家自然科学基金项目、广东省教育厅基础科研重大项目、广东省自然科学基金、广东省科技计划项目、广州市科技计划项目的研究；迄今以第一作者或通讯作者在JECCR，JACS Au, J. Med. Chem.，收录期刊发表研究论文120余篇，单篇论文影响因子12.65，H指数26；获得美国专利授权3件，欧洲专利授权1件，中国专利授权21项件，牵头和参与起草团标9项。

代表成果

[1]Wu, Q., Yuan, C., Wang, J., Li, G., Zhu, C., Li, L., Wang, Z., Lv,Q., Wenjie Mei* (梅文杰). Uridine-modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-negative Breast Cancer. JACS Au. 2024.
[2]Wu, Q., Yuan, C., Liu, N., Shu, J., Wang, J., Qian, J., Zeng, L., Zhang, H., Wang ,X., Wenjie Mei* (梅文杰). Fast detection, a precise and sensitive diagnostic agent for breast cancer. J Exp Clin Cancer Res. 2022, 41(1):201.
[3]Wu, Q., Zheng, K., Huang, X., Li, L., Wenjie Mei* (梅文杰). Tanshinone-IIA-Based Analogues of Imidazole Alkaloid Act as Potent Inhibitors To Block Breast Cancer Invasion and Metastasis in Vivo. J. Med. Chem., 2018, 61, 10488−10501.
[4]Zhang, H., Song, Y., Li, L., Zhang, S., Wu, Q., Mei Wen-Jie* (梅文杰), Liu, H., Wang, X., Phenanthroimidazole Derivatives Act as Potent Inducer of Autophagy by Activating DNA Damage Pathway. Bioorganic Chemistry, 2019, 88, 102940.
[5] Li, Y., Wu, Q., Yu, G., Li, L., Zhao, X., Huang, X., Mei Wen-Jie* (梅文杰). Polypyridyl Ruthenium(II) complex-induced mitochondrial membrane potential dissipation activates DNA damage-mediated apoptosis to inhibit liver cancer. European Journal of Medicinal Chemistry, 2019, 164, 282–291.
[6] Zhao, X., Li, L., Yu, G., Zhang, S., Li, Y., Wu, Q., Mei Wen-Jie* (梅文杰). Nucleus-enriched ruthenium polypyridine complex acts as a potent inhibitor to suppress triple-negative breast cancer metastasis in vivo. Computational & Structural Biotechnology Journal, 2018, 17, 21–30.
[7] Liu, X., Zhao, X., Li, Y., Zheng, K., Wu, Q., & Mei Wen-Jie* (梅文杰). Microwave-assisted synthesis, characterisation, and DNA-binding properties of Ru(II) complexes coordinated by norfloxacin as potential tumour inhibitors. Australian Journal of Chemistry, 2019, 72(5), 400-406.
[8] Lian, B., Wu, Q., Zhang, S., Li, Y., Zhao, X., Mei Wen-Jie* (梅文杰), & Wang, B. Tissue regeneration promotion effects of phenanthroimidazole derivatives through pro-inflammatory pathway activation. Fish & Shellfish Immunology, 2018, 80, 582–591.
[9] Zeng, Z., Wu, Q., Sun, F., Zheng, K., & Mei Wen-Jie* (梅文杰). Imaging Nuclei of MDA-MB-231 Breast Cancer Cells by Chiral Ruthenium(II) Complex Coordinated by 2-(4-Phenyacetylenephenyl)-1H-imidazo[4,5f][1,10]phen-anthroline. Inorganic Chemistry, 2016, 55(11), 5710–5718.
[10] Wu, Q., Zheng, K., Liao, S., Ding, Y., Li, Y., & Mei Wen-Jie* (梅文杰). Arene ruthenium(II) complexes as low-toxicity inhibitor against the proliferation, migration, and invasion of mda-mb-231 cells through binding and stabilizing cmyc gquadruplex dna. Organometallics, 2016, 35(3),317-326.

*以上信息由高级会员个人更新和维护。