杨朝勇

男， 厦门大学化学化工学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2008.01-至今，厦门大学化学生物学系，教授、博导
2006.09-2007.12，加州大学伯克利分校化学系, 博士后, 导师: Richard Mathies
2001.08-2006.08，美国佛罗里达大学，生物分析化学博士，导师: 谭蔚泓
1994.09-2001.07，厦门大学化学系，本科，硕士，导师：王小如

研究领域和兴趣

体外诊断新技术; 细胞识别、富集与成像; 高通量单细胞测序; 生物分析化学；微流控技术在生物医学中的应用

主要业绩

杨朝勇教授，国家杰出青年科学基金获得者，英国皇家化学会Fellow、谱学分析与仪器教育部重点实验室副主任、中国化学会化学生物学专业委员会副主任。相继于1998和2001年在厦门大学化学系获得学士与硕士学位，2006年获得美国佛罗里达大学博士学位，2006年9月至2007年12月在美国加州大学伯克利分校从事博士后研究。目前在Acc. Chem. Res.、PNAS、JACS、Angew. Chem. Int. Ed等学术刊物上发表论文180余篇。获授权专利30余项。研究工作被美国Washington Times、The Scientist、英国RSC Chemistry World、欧洲Wiley Chemistry Views、JACS Spotlights、光明日报、解放日报等媒体与刊物做了专题报道。先后获得了美国化学会分析化学研究生奖、中国政府国家优秀自费留学生奖、中美化学与化学生物学教授协会杰出教授奖、中国青年分析化学家奖、中国化学会-英国皇家化学会青年化学奖、科技部中青年科技创新领军人才等奖项与荣誉。现任ACS Applied Bio Materials 副主编、BMC Biochemistry 副主编、Analytical Chemistry、Lab on a Chip、Talanta、Analyst、Biomicrofluidics、Journal of Analysis and Testing、Scientific Reports等期刊编委。作为项目负责人主持国家自然科学基金6项，科技部课题3项，包括国家重大科研仪器研制项目（2019），国家自然科学基金委重点项目（2018），国家杰出青年科学基金（2013）、科技部973课题、国家重点研发计划合成生物学重点专项课题等。

代表成果

1. Cao,  J; Zheng,  Z; Sun, D; Chen, X; Cheng, R; Lv, T; An, Y; Zheng, J*; Song, J*; Wu, L*; Yang, C*; Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing. Nat. Biotechnol. 2024, DOI: https://doi.org/10.1038/s41587-023-02086-y
2. Yu, X; Ruan, W; Lin, F; Qian, W; Zou, Y; Liu, Y; Su, R; Niu, Q; Ruan, Q; Lin, W; Zhi Zhu, Zhang, H* ; Yang, C*, Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq), Proc. Natl. Acad. Sci. U. S. A., 2023, 120, e2221934120
3. Lin, S; Yin, K;Zhang, Y; Lin, F; Chen, X; Zeng, X; Guo, X; Zhang, H; Song, J*, Yang, C*. Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of temporal dynamics in single-cells. Nat. Commun., 2023, 14, 1272
4. Niu, Q; Gao, J; Zhao, K; Chen, X; Lin, X; Huang, C; An, Y; Xiao, X; Wu, Q; Cui, L*; Zhang, P*; Wu, L*; Yang, C*; Fluid Nanoporous Microinterface Enables Multiscale-Enhanced Affinity Interaction for Tumor-Derived Extracellular Vesicle Detection. Proc. Natl. Acad. Sci. U. S. A., 2022, 119, e2213236119
5. Sun, M; Liu, S; Wei, X; Wan, S; Huang, M; Song, T; Lu, Y; Weng, X; Zhu, L; Chen, H*; Song, Y*; Yang, C*; Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection, Angew. Chem. Int. Ed., 2021, 60, 2-9
6. Lin, B; Tian, T; Lu, Y; Liu, D; Huang, M; Zhu, L; Zhu, Z; Song, Y*; Yang, C*; Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR, Angew. Chem. Int. Ed., 2021, 7582-7586
7. Wu, L; Wang, Y; Xu,X; Liu, Y; Lin, B; Zhang, M, Zhang, J; Wan, S; Yang, C*; Tan, W*; Aptamer-Based Detection of Circulating Targets for Precision Medicine, Chem. Rev., 2021, 121, 12035–12105
8. Huang, M#; Li, T#; Xu, Y; Wei, X; Song, J; Lin,B; Zhu, Z; Song, Y*; Yang, C*; Activation of Aptamers with Gain-of-Function by Small-Molecule Clipping of Intramolecular Motifs, Angew. Chem. Int. Ed., 2021, 60, 6021-6028
9. Ruan, Q; Ruan, W; Lin, X; Wang, Y; Zou, F; Zhou, L; Zhu, Z; Yang, C*; Digital-WGS: Automated, Highly Efficient Whole-genome Sequencing of Single Cells by Digital Microfluidics, Sci. Adv., 2020, 6: eabd6454
10. Lin, L; Wu, Q; Song, J; Du, Y; Gao, J; Song, Y; Wang, W*; Yang, C*; Revealing the in vivo Growth and Division Patterns of Mouse Gut Bacteria, Sci Adv., 2020, 6, eabb2531
11. Wang, W*; Zhang, N; Du, Y; Gao, J; Li, M; Lin, L; Czajkowsky, D; Li, X*; Yang, C*; Shao, Z. Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew Chem. Int. Ed., 2020, 132, 2-9
12. Zhang, J; Lin, B; Wu, L; Huang, M; Li, X; Zhang, H; Song, J; Wang, W; Zhao, G*; Song, Y*; Yang, C*; DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed., 2020, 59, 14115-14119
13. Lin, L; Song, J; Du, Y; Wu, Q; Gao, J; Song, Y; Yang, C*; Wang, W.*; Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling, Angew. Chem. Int. Ed., 2020, 59, 11923-11926
14. Zhang, M; Zou, Y; Xu, X; Zhang, X; Gao, M; Song, J; Huang, P; Chen, Q; Zhu, Z; Lin, W; Zare, R; Yang, C *; Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers, Nat. Commun., 2020, 11, 2118
15. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*; Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc., 2020, 142, 4800-4806
16. Huang, M; Yang, J; Wang, T; Song, J; Xia, J; Wu, L; Wang, W; Wu, Q; Zhu, Z; Song, Y*; Yang, C*; Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction, Angew. Chem. Int. Ed., 2020, 59, 4800-4805
17. Wang, W; Yang, Q; Du, Y; Zhou, X; Du, X; Wu, Q; Lin, L; Song, Y; Li, F; Yang, C*; Tan, W*; Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota, Angew. Chem. Int. Ed., 2020, 59, 2628-2633
18. Wang, W; Lin, L; Du, Y; Song, Y; Peng, X; Chen, X*; Yang, C*; Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes, Nature Commun., 2019, 10, 1317
19. Song, Y; Shi, Y; Huang, M; Wang, W; Wang, Y; Cheng, J; Lei, Z; Zhu, Z; Yang, C*; Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed., 2019, 58, 2236-2240
20. Chen, Y; Ke, G*; Ma, Y; Zhu, Z; Liu, M; Liu, Y; Yan, H*; Yang, C*; A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami, J. Am. Chem. Soc., 2018, 28, 8990-8996

*以上信息由高级会员个人更新和维护。