雷新响

男， 兰州大学化学化工学院天然产物化学全国重点实验室， 教授/研究员/教授级高工或同等级别

学习/工作经历

1997-2001 中南民族大学，理学学士
2005-2007 温州大学，理学硕士
2007-2012 中国科学院成都生物研究所，理学博士
2010-2011 耶鲁大学，从事mRNA研究，研究助理
2013-2014 南京大学 （合作导师：谭仁祥），博士后
2001-2015 温州大学，实验师、高级实验师、副研究员，分析测试中心，副主任、主任
2016-2023 中南民族大学药学院，教授，院长助理、副院长、国家级实验教学示范中心主任
2023-2024 兰州大学化学化工学院、功能有机分子化学国家重点实验室，三级教授
2025-至今 兰州大学化学化工学院、天然产物化学全国重点实验室，三级教授

研究领域和兴趣

有机分析化学和药物化学生物学

主要业绩

开发了“液晶介质辅助”的有机分子核磁共振(NMR)三维结构分析方法，并在NMR各向异性参数残留偶极耦合(RDC)构建有机小分子原子分辨率的三维结构方面取得了突破性进展。现开展环肽药物化学生物学研究和药物开发。以通讯作者在JACS, Angewandte Chemie International Edition, Science Advance, Chemical Science, ACS Nano, ACS Catalysis, Analytical Chemistry, Organic Letters, Chemical Communication等期刊上发表系列SCI论文80余篇。申请发明专利5件，参编英国皇家化学会(Royal Society of Chemistry, RSC)出版的学术专著《Residual Dipolar Couplings: Principles and Applications》一章节。任《Natural Products and Bioprospecting》编委；《Magnetic Resonance Letters》; 《Magnetic Resonance in Chemistry》国际编委。现任中国化学会有机分析专业委员会委员和中国分析测试协会磁共振分会委员，曾任湖北省药学会理事、湖北省晶体学会理事、浙江省分析测试协会理事，组织了3次国际学术会议和2次全国学术会议，在全国性和国际性学术会议上做报告50余次，被Nature，德国应用化学， Nature Communications等期刊邀请为审稿人。

代表成果

1. Wei Ming; Xiao-Qin Yanga; Li-Wen Bai; Wei-Kang Zhai; Yi-Fei Chen; A-Li Wang; Xiaolei Wang; Xinxiang Lei*, Thiol–Ene Photoclick Chemistry for Efficient Bicyclic Peptide Synthesis and Genetically Encoded Peptide Library. Angew. Chem. Int. Ed., 65, 2026, e18628. doi.org/10.1002/anie.202518628;
2. Li−Wen Bai; Peng Cheng; Ting Dan; Hua Xiang; Xiao−Qin Yang; Yi-Fei Chen; Shu-Sen Li; Zheng-Hui Li; Jin-Ming Gao; Xinxiang Lei*, Exploring Phage Peptide Scaffolds: Tyrosinase-Mediated Cyclization for Selective Generation of Bioactive Cyclic Peptides. J. Am. Chem. Soc., 147, 2025, 35090−35097. doi.org/10.1021/jacs.5c12291;
3. Li−Wen Bai; Ting Dan; Peng Cheng; Xiao−Qin Yang; Hua Xiang; Rong Huang; Qi Wang; Kai L; Jin−Ming Gao*; Xinxiang Lei*, Isothiocyanate-Mediated Cyclization of Phage-Displayed Peptides Enables Discovery of Macrocyclic Binders. Chemrxiv, 2024, DOI: 10.26434/chemrxiv-2024-zh6t7.
4. Xiang, Hua; Bai, Li−Wen; Zhang, Xin−Dan; Dan, Ting; Cheng, Peng; Yang, Xiao−Qin; Ai, Hong−Lian; Li, Kai; Lei, Xinxiang*. A facile strategy for the construction of phage display cyclic peptide library for the selection of functional macrocycles. Chemical Science, 15, 2024, 11847-11855. doi.org/10.1039/D4SC03207A;
5. Lin, Yuexiao; Li, Jiaqian; Qin, Si-Yong; Sun, Han; Yang, Yan-Ling; Navarro-Vazquez, Armando; Lei, Xinxiang*, Programmable alignment media from self-assembled oligopeptide amphiphiles for the measurement of independent sets of residual dipolar couplings in organic solvents. Chemical Science, 13, 2022, 5838-5845. DOI: 10.1039/d2sc01057g;
6. Qin, Si-Yong*; Jiang, Yan; Sun, Han; Liu, Han; Zhang, Ai-Qing; Lei, Xinxiang*, Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems using a Liquid Crystalline based Medium. Angew. Chem. Int. Ed., 59, 2020, 17097-17103. doi.org/10.1002/anie.202007243;
7. Li, Xiao-Lu; Chi, Lu-Ping; Navarro-Vazquez, Armando; Hwang, Songhwan; Schmieder, Peter; Li, Xiao-Ming; Li, Xin; Yang, Sui-Qun; Lei, Xinxiang*; Wang, Bin-Gui*; Sun, Han*, Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. J. Am. Chem. Soc., 142, 2020, 2301−2309. doi.org/10.1021/jacs.9b10961;
8. Lei, Xinxiang*; Qiu, Feng; Sun, Han; Bai, Liwen; Wang, Wen-Xuan; Xiang, Wensheng; Xiao, Hongping, A Self-Assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurement of Residual Dipolar Couplings in Methanol. Angew. Chem. Int. Ed., 56, 2017, 12857-12861. DOI: 10.1002/anie.201705123;
9. Zong, Wen; Li, Gao-Wei; Cao, Jiang-Ming; Lei, Xinxiang*; Hu, Mao-Lin; Sun, Han*; An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes. Griesinger, Christian; Tan, Ren Xiang*, Angew. Chem. Int. Ed., 55, 2016, 3690-3693. DOI: 10.1002/anie.201511435;
10. Lei, Xinxiang*; Xu, Zhen; Sun, Han; Wang, Shun; Griesinger, Christian; Peng, Li; Gao, Chao*; Tan, Ren X*. Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents. J. Am. Chem. Soc., 136, 2014, 11280-11283. doi.org/10.1021/ja506074a.

*以上信息由高级会员个人更新和维护。