李朝辉

男， 郑州大学化学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1997.09-2001.06，湖南大学化学化工学院，本科学生
2001.09-2007.03，湖南大学化学化工学院，硕博连读研究生
2007.03-2009.08，美国塔夫茨大学，博士后
2009.08-2011.04，美国太平洋西北国家实验室，博士后
2011.08-2012.11，郑州大学，讲师
2012.12-2020.09，郑州大学，教授
2020.09至今，郑州大学，学科特聘教授

研究领域和兴趣

生物纳米分析

主要业绩

李朝辉，教授，博士生导师，英国皇家化学会会士，化学学院副院长，生命分析化学研究所所长，郑州大学第一附属医院兼职教授。中原基础研究领军人才，河南省杰出青年基金获得者。兼任河南省功能分子绿色构建与生物分析国际联合实验室执行主任，郑州市功能纳米材料与医学诊疗重点实验室主任，Chinese Chemical Letters编委，Analytica Chimica Acta编委，Journal of Analysis and Testing青年编委，Journal of Pharmaceutical Analysis青年编委，Research青年编委等。中国化学会高级会员，河南省化学会常务理事。主要从事癌症、阿尔兹海默病等重大慢病精准诊疗方面的基础与应用研究工作，主持承担国家自然科学基金、国家重点研发计划子课题、河南省杰出青年科学基金等项目20多项，迄今在Chemical Society Reviews，Journal of the American Chemical Society，CCS Chemistry等国际权威学术刊物上发表SCI论文250余篇，累计被引用超12000次，H-Index 54，授权发明专利30件，受邀参编英文学术专著5部；开发了40余个单分子免疫测定试剂盒，用于癌症、阿尔兹海默等重大疾病的早期预警与疗效评估，部分已推广到临床应用。先后荣获中原基础研究领军人才、中国分析测试协会科学技术奖一等奖、河南省科学技术进步一等奖、河南省教育厅科技成果一等奖等奖项多项。

代表成果

1. Yuanqiang Sun, Pengjuan Sun, Lingbo Qu, Zhaohui Li, Wei Guo. Natural Flavylium-Inspired Far-Red to NIR-II Dyes and Their Applications as Fluorescent Probes for Biomedical Sensing. Chemical Society Reviews, 2022, 51, 7170-7205
2. Hongzhi Sun, Di Zhao, Yating He, Hong-Min Meng, and Zhaohui Li. Aptamer-based DNA Allosteric Switch for Regulation of Protein Activity. Advanced Science, 2024, DOI: 10.1002/advs.202402531
3. Yanan Wu, Yating He, Miaomiao Han, Di Zhao, Bojun Liu, Kun Yuan, Hongzhi Sun, Hongmin Meng, and Zhaohui Li. Dual-miRNA-Propelled 3D DNA Walker for Highly Specific and Rapid Discrimination of Breast Cancer Cell Subtypes in Clinical Tissue Samples. CCS Chemistry, 2023, 5:7, 1561-1573.
4. Kun Yuan, Hongmin Meng, Yanan Wu, Juan Chen, Hui Xu, Lingbo Qu, Lele Li, Zhaohui Li. Extracellular Milieu and Membrane Receptor Dual-Driven DNA Nanorobot for Accurate in vivo Tumor Imaging. CCS Chemistry, 2022, 4, 1597-1609.
5. Yifei Guo, Yuanqiang Sun, Xin Geng, Junli Wang, Jingyu Hu, Rong-Bin Song, Ran Yang, Lingbo Qu, Zhaohui Li. GABAA Receptor-Specific Carbon Dots for High-Contrast Hepatocellular Carcinoma Imaging and Differentiation. Advanced Functional Materials, 2024, DOI: 10.1002/adfm.202401744.
6. Xin Geng, Yifei Guo, Ying Wang, Yongxin Zhai, Beining Xu, Lingbo Qu, Zhaohui Li. Revealing the adverse effects of trace amount broad-spectrum antimicrobial: a direct and sensitive visualization method based on carbon nanoprobe. Advanced Functional Materials, 2022, 32:43, 2206753
7. Jingyu Hu, Xin Geng, Yuanqiang Sun, Junli Wang, Yifei Guo, Yuanqiang Sun, Lingbo Qu, Ke Zhang and Zhaohui Li. High-fidelity Carbon Dots Polarity Probes: Revealing the Heterogeneity of Lipids in Oncology. Light: Science & Applications, 2022, 11, 1555-1564.
8. Bojun Liu, Di Zhao, Juan Chen, Mingqing Shi, Kun Yuan, Hongzhi Sun, Hong-Min Meng, and Zhaohui Li. DNA Logical Device Combining an Entropy-Driven Catalytic Amplification Strategy for the Simultaneous Detection of Exosomal Multiplex miRNAs In Situ. Analytical Chemistry, 2024, DOI: 10.1021/acs.analchem.3c04883.
9. Qiyong Cai, Shuiling Jin, Hong Zong, Lu Pei, Ke Cao, Lingbo Qu, Zhaohui Li. A Quadruplex Ultrasensitive Immunoassay for Simultaneous Assessment of Human Reproductive Hormone Proteins in Multiple Biofluid Samples. Analytical Chemistry, 2023, DOI: 10.1021/acs.analchem.3c01399.
10. Zengqiang Liang, Yuanqiang Sun, Huajing Zeng, Haimei Qin, Ran Yang, Lingbo Qu, Ke Zhang, Zhaohui Li. Broad-Specificity Screening of Pyrethroids Enabled by the Catalytic Function of Human Serum Albumin on Coumarin Hydrolysis. Analytical Chemistry, 2023, 95, 13, 5678–5686.

*以上信息由高级会员个人更新和维护。