栾玉霞

女， 山东大学药学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1995.9－1999.7 山东师范大学 化学系 本科生
1999.9－2004.6 山东大学胶体与界面化学教育部重点实验室 博士生
2004.7－2005.8 山东大学药学院 讲师
2005.9－2006.8 法国法国国家研究中心 （CNRS）及蒙彼利埃第二大学胶体化学实验室，助理研究员
2006.9－2007.8德国 慕尼黑工业大学，生物物理实验室，博士后
2007.9－2008.8 山东大学药学院 讲师
2008.9－2013.8 山东大学药学院 副教授
2013.9- 至今 山东大学药学院 教授

研究领域和兴趣

胶体化学；药剂学；肿瘤治疗

主要业绩

主要基于两亲分子的理念设计新型药物递送系统用于抗肿瘤治疗研究。设计、合成及构建了一系列具有高载药量、靶向高富集及肿瘤微环境响应性给药功能的新型药物递送系统，实现了药物的高效抗肿瘤治疗效果，研发出一系列有广阔应用前景的新型制剂。自2015年以来以通讯作者发表SCI论文52篇，其中IF>5.0的论文32篇，包括较高影响力的杂志如Prog. Polym. Sci.，Adv. Funct. Mater.，Small，Nano Lett.，Chem. Comm., Chem. Eng. J.，Biomaterials，Nanoscale Horiz.，ACS Appl. Mater. Interfaces，J. Controlled Release，J. Colloid Interface Sci.，Adv. Healthcare Mater.，Acta Biomater.，Biomacromolecules，Mater. Sci. Eng., C，J. Mater. Chem. B等，2015年以来以通讯作者发表的SCI论文得到国际同行的正面引用（他引次数1290次）。已授权国家发明专利13件，荣获中国药学会-石药集团青年药剂学奖1项。

代表成果

1. Jing Zhang, Ningning Wang, Qian Li, Yaxin Zhou, Yuxia Luan*, A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer, Chem. Commun., 2021, 57, 2305-2308.
2. Yaxin Zhou, Xiaomeng Ren, Zhaosheng Hou, Ningning Wang, Yue Jiang, Yuxia Luan*, Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation, Nanoscale Horizons, 2021, 6, 120-131.
3. Shiyao Zhou, Qi Shang, NingningWang, QianLi, Aixin Song, Yuxia Luan*, Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone, J. Controlled Release, 2020, 328, 617-630.
4. Huiyuan Zhang, Jing Zhang, Qian Li, Aixin Song, Hailong Tian, Jiqian Wang, Zhonghao Li, Yuxia Luan*, Site-specific MOF-based immunotherapeutic nanoplatforms via synergistic tumor cells-targeted treatment and dendritic cells-targeted immunomodulation, Biomaterials, 2020, 245, 119983.
5. Hailong Tian, Jing Zhang, Huiyuan Zhang, Yue Jiang, Aixin Song, Yuxia Luan*, Low side-effect and heat-shock protein-inhibited chemo-phototherapy nanoplatform via co-assembling strategy of biotin-tailored IR780 and quercetin, Chem. Eng. J., 2020, 382, 123043.
6. Jing Zhang, Di Zhang, Qian Li, Yue Jiang, Aixin Song, Zhonghao Li, Yuxia Luan*, Task-specific design of immune-augmented nanoplatform to enable high-efficiency tumor immunotherapy, ACS Appl. Mater. Interfaces, 2019, 11, 42904-42916.
7. Qian Li, Di Zhang, Jing Zhang, Yue Jiang, Aixin Song, Zhonghao Li, Yuxia Luan*, A three-in-one immunotherapy nanoweapon via cascade-amplifying cancer-immunity cycle against tumor metastasis, relapse, and postsurgical regrowth, Nano Letters, 2019, 19, 9, 6647-6657.
8. Huiyuan Zhang, Qian Li, Ruiling Liu, Xinke Zhang, Zhonghao Li, Yuxia Luan*, A versatile prodrug strategy to in situ encapsulate drugs in MOF nanocarriers: a case of cytarabine-IR820 prodrug encapsulated ZIF-8 toward chemo-photothermal therapy, Adv. Funct. Mater. 2018, 28, 1802830.
9. Xu Hu, Hailong Tian, Wei Jiang, Aixin Song, Zhonghao Li, Yuxia Luan*, Rational design of IR820 and Ce6 based versatile micelle for single NIR laser induced imaging and dual-modal phototherapy, Small, 2018, 14, 1802994.
10. Yuxia Luan, Laurence Ramos*, Real-time observation of polyelectrolyte-induced binding of charged bilayers, J. Am. Chem. Soc., 2007, 129, 14619-14624.

*以上信息由高级会员个人更新和维护。