梁高林

男， 东南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1989.09－1993.07 南京大学，本科。
1993.08－2002.09 江苏省原子医学研究所，助理研究员。
2000.09－2002.07 郑州大学，硕士。
2002.09－2005.07 复旦大学，博士。
2005.09－2008.01 香港科技大学，博士后。
2008.01－2010.05 美国斯坦福大学，博士后。
2010.03－2021.03 中国科学技术大学，教授。
2018.12－现在 东南大学，教授。

研究领域和兴趣

成像分析、生物医药

主要业绩

长期从事肿瘤生物标志物检测与活体成像研究，在CBT-Cys点击反应、多功能纳米探针设计、生物成像及药物递送等方向取得了系统性创新成果。近年来，发展了一系列基于CBT-Cys点击反应的活体成像探针设计策略，并在重大疾病（如癌症、神经退行性疾病等）的早期诊断和疗效评估中取得了突破性成果。申请人自2010年以第一作者身份报道生物兼容的CBT-Cys点击反应并将其应用在活细胞内自组装纳米结构以来（Nat. Chem. 2010, 2(1), 54-60），先后在Sci. Adv.、Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.等期刊发表高水平研究论文200余篇，总被引超12000余次，H因子57，在分子影像与纳米医学领域具有广泛学术影响力。

代表成果

1. Yu Deng, Lingling Xu, Xiaoyang Liu, Qiaochu Jiang, Xianbao Sun, Wenjun Zhan*, and Gaolin Liang*. Tandem Targeting and Dual Aggregation of an AIEgen for Enhanced Near-Infrared Fluorescence Imaging of Tumors. J. Am. Chem. Soc. 2024, 146(37), 25462-25466. DOI: 10.1021/jacs.4c10606.
2. Rui Wang, Lei Zhou, Yueyan Yang, Furong Zhao, Xianbao Sun, Xiaoyang Liu, Zhen Zou, and Gaolin Liang*. Spatially Quantitative Imaging of Enzyme Activity in a Living Cell. J. Am. Chem. Soc. 2024, 146(50), 34870-34877. DOI: 10.1021/jacs.4c14190.
3. Xiaofeng Wu, Yu Deng, Ying Xu, Heemin Kang*, Jing-Jing Hu*, Juyoung Yoon,* and Gaolin Liang*. Activatable Fluorescence and Bio/Chemiluminescence Probes for Aminopeptidases: From Design to Biomedical Applications. Adv. Mater. 2024, 36(45), 2409893. DOI: 10.1002/adma.202409893.
4. Han Yin, Yue Hua, Songwei Feng, Yi Xu, Yue Ding, Sicong Liu, Dongsheng Chen, Furong Du, Gaolin Liang,* Wenjun Zhan,* and Yang Shen*. In Situ Nanofiber Formation Blocks AXL and GAS6 Binding to Suppress Ovarian Cancer Development. Adv. Mater. 2024, 36(21), 2308504. DOI: 10.1002/adma.202308504.
5. Xiaofeng Wu, Yu Deng, Rui Wang, Heejeong Kim, Gyoungmi Kim, Ying Xu, Kyung Tae Hong, Jun-Seok Lee, Jing-Jing Hu,* Gaolin Liang,* and Juyoung Yoon*. Rational Design of an Activatable Near-Infrared Fluorogenic Platform for In Vivo Orthotopic Tumor Imaging and Resection. Angew. Chem. Int. Ed. 2024, 36(45), e202416877. DOI: 10.1002/anie.202416877.
6. Lingling Xu, Hang Gao, Wenjun Zhan, Yu Deng, Xiaoyang Liu, Qiaochu Jiang, Xianbao Sun, Jing-Juan Xu, and Gaolin Liang*. Dual Aggregations of a Near-Infrared AIEgen for Enhanced Imaging of Alzheimer’s Disease. J. Am. Chem. Soc. 2023, 145(50), 27748-27756. DOI: 10.1021/jacs.3c10255.
7. Qiaochu Jiang, Wenjun Zhan, Xiaoyang Liu, Lin Bai, Manli Wang, Ying Xu, and Gaolin Liang*. Assembly drives regioselective azide-alkyne cycloaddition reaction. Nat. Commun. 2023, 14, 3935. DOI: 10.1038/s41467-023-39658-0.
8. Wenjun Zhan, Lingling Xu, Zhiyu Liu, Xiaoyang Liu, Ge Gao, Tiantian Xia, Xiaotong Cheng, Xianbao Sun, Fu-Gen Wu, Qian Yu, and Gaolin Liang*. Tandem Guest-Host-Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus. Angew. Chem., Int. Ed. 2023, 62(32), e202306427. DOI:10.1002/anie.202306427.
9. Xiaoyang Liu, Wenjun Zhan, Ge Gao, Qiaochu Jiang, Xinping Zhang, Hongbo Zhang, Xianbao Sun, Wei Han, Fu-Gen Wu, and Gaolin Liang*. Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor. J. Am. Chem. Soc. 2023, 145(14), 7918-7930. DOI: 10.1021/jacs.2c13189.
10. Ge Gao, Yao-Wen Jiang, Wenjun Zhan, Xiaoyang Liu, Runqun Tang, Xianbao Sun, Yu Deng, Lingling Xu, and Gaolin Liang*. Trident Molecule with Nanobrush-Nanoparticle-Nanofiber Transition Property Spatially Suppresses Tumor Metastasis. J. Am. Chem. Soc. 2022, 144(26), 11897-11910. DOI: 10.1021/jacs.2c05743.

*以上信息由高级会员个人更新和维护。