金京一

男， 延边大学理学院化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1989.09-1993.07，吉林化工学院/有机化工专业，本科学生
1993.11-1996.09，吉林化学工业公司江南设计研究院，工艺员
1996.09-1999.07，延边大学/有机化学专业，硕士研究生
1999.9-2003.09，延边大学/有机化学专业，博士研究生
2003.10-2005.09，北京大学化学与分子工程学院，博士后
2005.10-2009.08，延边大学/化学系，副教授
2009.09至今，延边大学/化学系，教授

研究领域和兴趣

金属蛋白酶的高效抑制剂与特异性标记；细胞氧化还原生物学；生物小分子标记

主要业绩

1. 在含锌金属蛋白水解酶抑制剂研究方面，设计了一类以硝基为锌离子结合基团的赝过渡态类抑制剂，开发了系列的羧肽酶A、嗜热菌蛋白酶、基质金属蛋白酶抑制剂；并实现了对基质金属蛋白酶-7的高选择性抑制，在抗肿瘤转移、改善小儿先天性胆道闭锁方面有较好的临床应用前景；
2. 针对细胞内氧化还原稳态的调控机制，发展了系列的活性氧、活性氮、活性硫小分子荧光探针；
3. 在上述研究涉及的有机合成方面，提出了选择性合成肽键和派罗宁修饰的新方法。

代表成果

1. Ling-Li Wang, Yu-Zhuo Mai, Ming-Hua Zheng, Guang-Hai Yan, Jing-Yi Jin. A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracelllar vesicle role in ferroptosis. Developmental Cell, 2024, 59, 517-528.
2. Ling-Li Wang, Qian Xu, Yu-Zhong Xie, Ya-Ru Zhang, Ming-Hua Zheng, Xi-Feng LI, Jing-Yi JIn. A triple-targeting fluorescent probe reveals the glutathione and viscosity crosstalk in mitochondria, endoplasmic reticulum, and nucleoli in cells during ferroptosis. Sens. Actuators B. Chem. 2024, 399, 134872.
3. Ling-Li Wang, Ya-Ru Zhang, Ming-Hua Zheng, Xuan Wang, Jing-Yi Jin. A single fluorescent probe reveals changes in endoplasmic reticulum-mitochondria contact in hepatocytes during ferroptosis. Chemical Engineering Journal, 2023, 466, 143104.
4. Ling-Li Wang, Yu-Zhuo Mai, Ming-Hua Zheng, Xue Wu, Jing-Yi Jin. Fluorescent probe disclosing hydroxyl radical generation in mitochondria and nucleoli of cells during ferroptosis. Sens. Actuators B. Chem., 2022, 373, 132707.
5. Ling-Li Wang, Jian-Ying Bai, Xi-Feng Li, Ming-Hua Zheng, Yu Miao, Jing-Yi Jin. Simultaneous imaging of hypochlorous acid and nitric oxide in live cells based on a dual-channel fluorescent probe. Anal. Chim. Acta, 1183 (2021), 338980. DOI: 10.1016/j.aca.2021.338980.
6. Yu-Zhuo Mai, Yu-Zhong Xie, Ming-Hua Zheng, Xin Zhou, Jing-Yi Jin. Facile synthesis of pyronin-9-thione via a trisulfur radical anion mechanism. New J. Chem., 45 (2021), 19-22. DOI: 10.1039/d0nj04808a.
7. Ling-Li Wang, Bing Zhang, Ming-Hua Zheng, Yu-Zhong Xie, Chang-Jiang Wang, Jing-Yi Jin. Matrix metalloproteinases (MMPs) in targeted drug delivery: synthesis of a potent and highly selective inhibitor against matrix metalloproteinase-7. Cur. Top. Med. Chem., 20 (2020), 2459-2471. DOI: 10.2174/1568026620666200722104928.
8. Yue Wang, Ming-Yang Yang, Ming-Hua Zheng, Xiao-Long Zhao, Yu-Zhong Xie, Jing-Yi Jin. 2-Pyridylthiazole derivative as ICT-based ratiometric fluorescent sensor for Fe(III). Tetrahedron Lett., 57 (2016), 2399-2402. DOI: 10.1016/j.tetlet.2016.04.065.
9. Guan Rong Tian, Si-Hong Wang, Shou-Feng Wang, Ling-Qiang Meng, Hui Li, Zong-Hao Zeng, Jing-Yi Jin. Nitro-based inhibitors against thermolysin. Med. Chem. Comm., 2 (2011), 698. DOI: 10.1039/c1md00088h.
10. Wang Shou-Feng, Tian Guan Rong, Zhang Wen-Zheng, Jin Jing-Yi. Characterization of α-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A. Bioorg. Med. Chem. Lett., 19 (2009), 5009-5011. DOI: 10.1016/j.bmcl.2009.07.060.
11. Wang Si-Hong, Wang Shou-Feng, Xue Wei, Zeng Zong-Hao, Jin Jing-Yi, Ma Jie, Tian Guan Rong. Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A. Bioorg. Med. Chem., 16 (2008), 3596-3601. DOI: 10.1016/j.bmc.2008.02.010.
12. Li Le-Le, Sun Hao, Fang Chen-Jie, Xu Jun, Jin Jing-Yi, Yan Chun-Hua. Optical sensors based on functionalized mesoporoius silica SBA-15 for the detection of multianalytes (H+ and Cu2+) in water. J. Mater. Chem., 17 (2007), 4492-4498. DOI: 10.1039/b708857d.
13. Jing-Yi Jin, Guan Rong Tian, Dong H. Kim. Optically active 2-benzyl-3-methanesulfinylpropanoic acid: synthesis and evuluation as inhibitors for carboxypeptidase A. Bioorg. Med. Chem., 11 (2003), 4377-4382. DOI: 10.1016/S0968-0896(03)00481-4.
14. 金京一; 王翎力; 吴梦兰; 黄杰涛; 麦愉卓; 郑明花，基于1,8-二氨基萘单元的次氯酸和一氧化氮荧
光探针；2018-05-16、201810470922.7；2021-3-16、 ZL 2018 1 0470922.7.

*以上信息由高级会员个人更新和维护。