刘震

男， 南京大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1988.09-1992.06，贵州大学化学系，本科生；
1992.09-1995.06，南京大学化学系，硕士生；
1995.09-1998.06，中国科学院大连化学物理研究所，博士生；
1998.07-2000.01，中国科学院大连化学物理研究所，助理研究员；
2001.02-2002.01，日本兵库大学理学部，日本学术振兴会（JSPS）特别研究员；
2002.02-2007.08，中国科学院大连化学物理研究所，访问学者；
2002.08-2005.11，加拿大滑铁卢大学化学系，博士后；
2005.11-今，南京大学化学化工学院，教授

研究领域和兴趣

生物分离、生物质谱、仿生分子识别、疾病诊断、单细胞分析、纳米医学

主要业绩

2005年获聘南京大学教授，2006年起任博士生导师，2008年入选教育部“新世纪优秀人才”， 2011年-2014年任加拿大滑铁卢大学工程学院兼职教授，2014年获国家杰出青年科学基金，2016年入选江苏省“333高层次人才”（第二层次）。兼任国际分子印迹学会理事会理事、中国质谱学会常务理事、中国化学会质谱专业委员会委员、中国生物化学与分子生物学会蛋白质组学专业委员会委员、《Analytica Methods》副主编、《Analytica Chimica Acta》、《Electrophoresis》、《Separation Science Plus》、《科学通报》、《分析化学》、《质谱学报》和《色谱》等杂志编委。主持国家重大科研仪器项目和基金委重点项目等国家级科研项目10余项，已在Chemical Society Review，Accounts of Chemical Research，Angewandte Chemie International Edition，Nature Protocols，Chemical Science等期刊上发表论文140余篇，目前h因子46（谷歌学术），主编及合著著作2部，出版专章7章，获授权专利12项。2011年和2017年先后获中国分析测试协会科学技术奖一等奖共2次，2016年获Phenomenex & Analytical Scientist联合颁发的科学人文奖银奖。2020年荣获美国化学会（ACS）测量科学进展讲座奖（Advances in Measurement Science Lectureship Award）。主要从事分子识别、亲和分离、疾病诊断、单细胞分析和癌症纳米治疗等研究，主要代表性成果有：1、系统深入地研究了硼亲和色谱及相关亲和材料及技术；2、建立了多个便捷高效的分子印迹方法，推动了分子印迹聚合物在生物医学等重要领域中的应用；3、建立了等离激元免疫夹心法，成功应用于疾病诊断和单细胞分析等领域；4、提出了基于分子印迹聚合物的抗癌纳米药物 。

代表成果

I. 论文：
1. Menghuan Zhao, Peixin Guan, Shuxin Xu, Haifeng Lu, Zhen Liu*. Molecularly imprinted nanomedicine for anti-angiogenic cancer therapy via blocking VEGF signaling. Nano Letters, 2023, 23, 18, 8674–8682.
2. Jingran Chen, Shuxin Xu, Qing Ye, Hang Chi, Ying Li, Mei Wu, Baochao Fan, Zhanchen Guo, Cheng-Feng Qin, Bin Li, Zhen Liu*. A topology-matching spike protein-capping tetrahedral DNA nanocrown for SARS-CoV-2 neutralization. CCS Chemistry, 2023, 5, 1372–1385.
3. Zikuan Gu, Zhanchen Guo, Song Gao, Lingrui Huang, Zhen Liu*. Hierarchically structured molecularly imprinted nanotransducers for truncated HER2-targeted photodynamic therapy of therapeutic antibody-resistant breast cancer. ACS Nano, 2023, 17, 10152–10163.
4. Wei Li, Shuxin Xu, Ying Li, Jingran Chen, Yanyan Ma, Zhen Liu*. High mannose-specific aptamers for broad-spectrum virus inhibition and cancer targeting. CCS Chemistry, 2023, 5, 497-509.
5. Juntao Zhou, Xianhui Cheng, Zhanchen Guo, Muhammad Mujahid Ali, Guiyuan Zhang, W. Andy Tao, Lianghai Hu*, Zhen Liu*. Epitope imprinting of phospholipids by oriented assembly at oil/water interface for the selective recognition of plasma membranes. Angewandte Chemie International Edition, 2023, 62, e202213938 (Hot paper).
6. Peixin Guan, Zhanchen Guo, Shuxin Xu, Haifeng Lu, Lisheng Wang, Zikuan Gu, Zhen Liu*. Molecularly imprinted nanobeacons redirect innate immune killing towards triple negative breast cancer. Angewandte Chemie International Edition, 2023, 62, e202301202 (Hot paper).
7. Pengfei Li, Shuxin Xu, Yanjie Han, Hui He, Zhen Liu*. Machine learning-empowered cis-diol metabolic fingerprinting enables precise diagnosis of primary liver cancer, Chemical Science, 2023, 14, 2553 – 2561.
8. Hui He, Lingli Zhou, Zhanchen Guo, Pengfei Li, Song Gao, Zhen Liu*. Nanogap-enhanced Raman scattering for ultrasensitive protein fingerprinting and quantitation. Nano Letters, 2022, 22, 23, 9664–9671.
9. Ying Li, Shuxin Xu, Qing Ye, Hang Chi, Zhanchen Guo, Jingran Chen, Mei Wu, Baochao Fan, Bin Li, Cheng-Feng Qin*, Zhen Liu*. Rational development of hypervalent glycan shield-binding nanoparticles with broad-spectrum inhibition against fatal viruses including SARS-CoV-2 variants. Advanced Science, 2022, 10, 202202689.
10. Shuxin Xu, Menghuan Zhao, Zikuan Gu, Haifeng Lu, Zhen Liu*. Photothermal therapy of neuroblastoma via polysialic acid-targeting nanomissiles. Small, 2022, 18, 2201671.
11. Zikuan Gu, Shuxin Xu, Zhanchen Guo, Zhen Liu*. Rational development of molecularly imprinted nanoparticles for blocking PD-1/PD-L1 axis. Chemical Science, 2022, 13, 10897-10903.
12. Jilei Pang, Pengfei Li, Hui He, Shuxin Xu, Zhen Liu*. Molecularly imprinted polymers outperform lectin counterparts and enable more precise cancer diagnosis. Chemical Science, 2022,13, 4589-4597.
13. Pengfei Li, Jilei Pang, Shuxin Xu, Hui He, Yanyan Ma, Zhen Liu*. A glycoform-resolved dual-modal ratiometric immunoassay improves the diagnostic precision for hepatocellular carcinoma. Angewandte Chemie International Edition, 2022, 61, e202113528 (Hot paper).
14. Rongrong Xing, Zhanchen Guo, Haifeng Lu, Qi Zhang, Zhen Liu*. Molecular imprinting and cladding produces antibody mimics with significantly improved affinity and specificity. Science Bulletin, 2022, 67, 278-287.
15. Zhanchen Guo, Rongrong Xing, Menghuan Zhao, Ying Li, Haifeng Lu, Zhen Liu*. Controllable engineering and functionalizing of nanoparticles for targeting specific proteins towards biomedical applications. Advanced Science, 2021, 8, 2101713 (Highly cited paper).
16. Haifeng Lu, Shuxin Xu, Zhanchen Guo, Menghuan Zhao, Zhen Liu*. Redox-responsive molecularly imprinted nanoparticles for targeted intracellular delivery of protein toward cancer therapy. ACS Nano, 2021, 15, 18214−18225.
17. Jia Liu, Hui He, Dan Xie, Yanrong Wen, Zhen Liu*. Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays. Nature Protocols, 2021, 16, 3522–3546.
18. Shuxin Xu, Lisheng Wang, Zhen Liu*. Molecularly imprinted polymer nanoparticles: An emerging versatile platform for cancer therapy. Angewandte Chemie International Edition, 2021, 60, 3858-3869.
19. Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang, Zhen Liu*. Molecularly imprinted polymer-based smart prodrug delivery system for specific targeting, prolonged retention and tumor microenvironment-triggered release. Angewandte Chemie International Edition, 2021, 60, 2663–2667.
20. Yueru Dong, Wei Li, Zikuan Gu, Rongrong Xing, Yanyan Ma, Qi Zhang, Zhen Liu*. Inhibition of HER2-positive breast cancer growth by blocking the HER2 signaling pathway with HER2 glycan-imprinted nanoparticles. Angewandte Chemie International Edition, 2019, 58, 10621-10625 (Hot paper, Featured in [Angewandte Chemie], [EurekAlert!], [SicenceDaily], [PhysOrg.com], [Cancernetwork], [Nanowerk], [Chemistryviews.org], [News-medical.net]…).
21. Rongrong Xing, Yanyan Ma, Yijia Wang, Yanrong Wen, Zhen Liu*. Specific recognition towards proteins and peptides via controllable oriented surface imprinting of boronate affinity-anchored epitope. Chemical Science, 2019, 10, 1831-1835.
22. Jia Liu, Yanrong Wen, Hui He, Hong-Yuan Chen, Zhen Liu*. Probing cytoplasmic and nuclear microRNAs in single living cells via plasmonic affinity sandwich assay. Chemical Science, 2018, 9, 7241 - 7246.
23. Zhen Liu*, Hui He. Synthesis and Applications of Boronate Affinity Materials: from Class-selectivity to Biomimetic Specificity. Accounts of Chemical Research, 2017, 50, 2185–2193 (Highly cited paper).
24. Rongrong Xing, Shuangshou Wang, Zijun Bie, Hui He, Zhen Liu*. Preparation of molecularly imprinted polymers specific to glycoproteins, glycans and monosaccharides via boronate affinity controllable oriented surface imprinting. Nature Protocols, 2017, 12, 964–987 (Highly cited paper).
25. Jia Liu, Danyang Yin, Shuangshou Wang, Hong-Yuan Chen, Zhen Liu*. Probing Low-Copy Number Proteins in a Single Living Cell. Angewandte Chemie International Edition, 2016, 55, 13215–13218.
26. Daojin Li, Yang Chen, Zhen Liu*. Boronate affinity materials for separation and molecular recognition: structure, properties and applications. Chemical Society Reviews, 2015, 44, 8097-8123 (Highly cited paper).
27. Zijun Bie, Yang Chen, Jin Ye, Shuangshou Wang, Zhen Liu*. Boronate-Affinity Glycan-Oriented Surface Imprinting: A New Strategy to Mimic Lectins for the Recognition of an Intact Glycoprotein and Its Characteristic Fragments. Angewandte Chemie International Edition, 2015, 54, 10211-10215 (VIP, Highly cited paper).
28. Xianghua Pan, Yang Chen, Peixuan Zhao, Daojin Li, Zhen Liu*. Highly Efficient Solid-Phase Labeling of Saccharides within Boronic Acid Functionalized Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 2015, 54, 6173–6176.
29. Jin Ye, Yang Chen, Zhen Liu*. Boronate Affinity Sandwich Assay: an Appealing Alternative of Immunoassay for the Determination of Glycoproteins. Angewandte Chemie International Edition, 2014, 53, 10386-10389.
30. Qianjin Li, Xueying Tu, Jin Ye, Zijun Bie, Xiaodong Bi, Zhen Liu*. Nanoconfining affinity materials for pH-mediated protein capture-release. Chemical Science, 2014, 5, 4065-4069.
31. Shuangshou Wang, Jin Ye, Zijun Bie, Zhen Liu*. Affinity-tunable specific recognition of glycoproteins via boronate affinity-based controllable oriented surface imprinting. Chemical Science, 2014, 5, 1135-1140.
32. Heye Wang, Zijun Bie, Chenchen Lü, Zhen Liu*. Magnetic nanoparticles with dendrimer-assisted boronate avidity for the selective enrichment of trace glycoproteins. Chemical Science, 2013, 4, 4298 - 4303.
33. Li Li, Yue Lu, Zijun Bie, Hong-Yuan Chen, Zhen Liu*. Photolithographic Boronate Affinity Molecular Imprinting: a General and Facile Approach for Glycoprotein Imprinting. Angewandte Chemie International Edition, 2013, 52, 7451-7454.
34. Yunchun Liu, Yue Lu, Zhen Liu*. Restricted access boronate affinity porous monolith as a protein A mimetic for the specific capture of immunoglobulin G. Chemical Science, 2012, 3, 1467-1471.
35. Lianbing Ren, Zhen Liu*, Yunchun Liu, Peng Dou, Hong-Yuan Chen. Ring-opening polymerization with synergistic co-monomers: access to a boronate-functionalized polymeric monolith for the specific capture of cis-diol-containing biomolecules under neutral conditions. Angewandte Chemie International Edition, 2009, 48, 6704-6707.

II. 专利
1、 刘震、李迎、许舒欣、郭展辰、陈静然。一种具有广谱抗病毒效果的纳米人工抗体及其制备方法。申请号：202210168578.2。申请日期：2022-02-23。授权号：CN114533754A。授权日期：2023-10-20。
2、 刘震、郭展辰、邢荣荣。基于反相微乳液的分子印迹及包覆聚合物、制备方法及用途。申请号：202110482677.3。申请日期：2021-07-26。授权号：CN115254048A。授权日期：2023-06-13。
3、 刘震、邢荣荣、郭展辰、张齐。一种分子印迹及包覆聚合物、其制备方法及用途。申请号：202110481022.4。申请日期：2021-07-14. CN115254047A。授权号：CN115254047A。授权日期：2023-10-27。
4、 刘震、邢荣荣、王益佳。一种通用便捷的表位印迹方法及所得分子印迹聚合物的应用。中国发明专利，申请号：201810538823.8。申请日期：2018-05-30。授权号：CN108722369B。授权日期：2020-12-25。
5、 刘震、刘佳、尹丹阳、涂雪莹、Pir Muhammad（皮耶 木合马徳）。一种不同亲和配基功能化的金基萃取材料及其在表面等离激元光学亲和夹心分析中的应用。中国发明专利，申请号：2016107374705。申请日期：2016-08-24。授权号：CN106442459B。授权日期：2020-02-07。
6、 刘震，别子俊，陈阳。基于分子印迹技术的凝集素模拟物的合成方法与应用。中国发明专利，申请号：201510182716.2。申请日期：2015-04-16。授权号：CN104820100A。授权日期：2017-05-03。
7、 刘震，李道金、张乾、刘百战。一种树枝状硼酸功能化整体柱及其制备方法和应用。中国发明专利，申请号：201410856918.6。申请日期：2014-12-29。授权公告号：CN 104549182 B；授权日期：2017-07-07。
8、 刘震，叶金。基于分子印迹技术和拉曼光谱的糖蛋白检测方法及应用。中国发明专利，申请号：201410255065.0。申请日期：2014-06-11。授权公告号：CN104122247B。授权日期：2017-01-25。
9、 刘震，王双寿。一种荧光纳米探针及其制备方法和应用。中国发明专利，申请号：2014100368865。申请日期：2014-01-26。授权日期：2016-03-12。CN103937486B。
10、 刘震，王双寿，毕晓东。一种可控、通用的定向表面印迹方法以及所得分子印迹聚合物的应用。中国发明专利，申请号：201310339600.6。申请日期：2013-08-06。授权日期：2016-08-10。授权公告号：CN103406109B。

III． 著作
1、 刘震 主编. 《现代分离科学》，北京：化学工业出版社，2017年8月. 标准书号：978-7-122-30157-4.
2、 邹汉法，刘震，叶明亮，张玉奎. 《毛细管电色谱及其应用》, 北京：科学出版社，2001年12月. 标准书号：7-03-009078-0/O.1323.

*以上信息由高级会员个人更新和维护。