孔德明

男， 南开大学化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1994.09-1998.07, 南开大学化学系, 本科学生
1998.09-2003.07, 南开大学化学学院, 分析化学博士生, 导师: 沈含熙
2003.07-2004.12, 南开大学化学学院, 讲师
2005.01-2009.12, 南开大学化学学院, 副教授
2010.01至今, 南开大学化学学院, 教授

研究领域和兴趣

生物分析化学

主要业绩

多年来一直从事生物传感和生物成像方面的研究工作，设计了多种基于DNA的生物传感新技术、新方法，实现了血清、细胞等实际生物样品中多种疾病相关的生物靶标（包括 DNA、microRNA、端粒酶、尿嘧啶 DNA 糖基化酶、限制性核酸内切酶、甲基转移酶、细菌、病毒及循环肿瘤细胞等）的高灵敏、高特异性定量检测。对多种纳米材料（如石墨烯、MOFs、磁性纳米粒子及金属纳米簇）在生物传感和生物成像中的应用研究进行了成功的探索，设计、制备了生物稳定性高、靶向识别能力强的荧光纳米探针及纳米载药体系，实现了疾病标志物的高灵敏检测、肿瘤细胞的靶向光学成像和诊疗一体化研究。构建了高度集成化的、自我驱动的DNA步行者纳米机器，首次实现了DNA步行者分子机器在活体中的应用研究等。
作为项目负责人，承担国家自然科学基金项目6项，重点研发计划子课题项目1项，天津市自然科学基金项目3项。作为通讯联系人，共有90余篇研究论文在“Nucleic Acids Research” 、“Chemical Science”、“Analytical Chemistry”、“Chemistry - A European Journal”、“Chemical Communications”、 “Biosensor & Bioelectronics”等国内外重要期刊上发表，授权发明专利3项。作为第二完成人获2008年度天津市自然科学二等奖；获2010年度中国化学会青年化学奖；入选2010年度教育部新世纪优秀人才支持计划； 2013年入选天津市131第二层次人才；2014年获国家自然科学基金委优秀青年基金资助。现担任Scientific Reports杂志编委，《高等学校化学学报》青年编委。

代表成果

1. Wei-Liang Jin, Li-Na Zhu*, Xiao-Bo Yang, De-Ming Kong*, Seaweed-inspired “iodine-mediated iodine capture” strategy enables sustainable radioiodine remediation. Advanced Functional Materials, 2025, e21013.
2. Xia-Jun Jin, Jing-Qi Liu, Hong-Xia Zhang, Qiang-Qiang Yu, Hong-Zhi Zhou, De-Ming Kong*, Li-Na Zhu*, Cyano cyclization-anchoring strategy breaks the activity-stability trade-off in COF photocatalysts. Chemical Engineering Journal, 2025, 524, 169066.
3. Chen-Yu Wang, Yong-Ji Li, Hao-Rui Li, Jing Wang, Wei-Da Liu, Jia-Rui Su, Rong-Hao Cui, Si-Wei Yang, Zhi-Li Yao, Qing-Nan Li, Gui-Mei Han, Jian-Xi Shi, Zheng Zhang, Zhun Wang, Zhi-Fei Liu, Ye-Gang Chen, Shuang-Qing Liu, Yan Zhao*, Shao-San Kang*, De-Ming Kong*, Qi-Liang Cai*, Precision tumor recognition in clear cell renal cell carcinoma: A qHCR platform leveraging tetrahedral DNA nanostructures for rapid molecular diagnosis. Aggregate, 2025, 0, e70151
4. Qing-Nan Li, Hao-Ran Huang, Hong-Xin Jiang*, Ruo-Yan Li, Qi-Liang Cai*, Xiao-Yun Hou, De-Ming Kong*, Position-independent single-nucleotide polymorphism discrimination by CRISPR/Cas12a via rational activator strand engineering. Biosensors and Bioelectronics, 2025, 289, 117929.
5. Jia-Yi Shi, Zi-Wen Li, Zhi-Li Yao, Gui-Mei Han, Man-Ying Li, Qi-Liang Cai*, De-Ming Kong*, 5′-end engineering of CRISPR/Cas12a activators: A versatile platform for multiple biomarker analysis and clinical cancer tissue identification. Analytical Chemistry, 2025, 97, 18188-18198.
6. Dong-Xia Wang, José Ignacio Gallea, De-Ming Kong*, Jörg Enderlein*, Tao Chen*, Super-resolution axial imaging for quantifying piconewton traction forces in live cells. Angewandte Chemie International Edition, 2025, e202506864
7. Jin-Fan Xu, Jun-Hao Chen, Wei Li*, Hong-Xin Jiang, De-Ming Kong*, Li-Na Zhu*, Preparation of hierarchically porous monolithic corn straw@COF composite for fat-rich food pretreatment in non-targeted analysis. Chemistry - A European Journal, 2025, e202501502.
8. Wei-Liang Jin, Hong-Xin Jiang, Xue-Mei Liu, Sheng-Hua Ma, Li-Na Zhu*, De-Ming Kong*, Selective capture of Scandium ions by designing chelation sites in covalent organic framework membranes. Small, 2025, 2502514
9. Sha Lu, Qiong Wang, Zhi-Qi Dai, Chen-Yu Wang, Jing Wang, Zhi-Li Yao, Jin-Ming Liu, Quan Chen*, Qi-Liang Cai*, Yun-Xi Cui*, De-Ming Kong*, Detection and in situ imaging of APE1 through self-initiated hyperbranched hybridization chain reaction of multifunctional DNA tetrahedral nanoprobes. Sensors and Actuators B-Chemistry, 2025, 443, 138171.
10. Si-Wei Yang, Jing Wang, Yan Tan, Xiao Jing, Chen-Yu Wang, Zhi-Li Yao, Wen-Hui Wang, Yong-Ji Li, Hao-Rui Li, Yan Zhao*, De-Ming Kong*, Qi-Liang Cai*, Functional nucleic acid-stabilized selenium nanotechnology enable synergistic healing of diabetic chronic wounds. Chemical Engineering Journal, 2025, 518, 164682.
11. Sha Lu, Ai-Xin Ma, Xiao-Lin Gao, Zhi-Qi Dai, Qing-Nan Li, Yang-Yang Liu, Yi Zhang, Qi Meng, Dai-Wen Pang*, Yun-Xi Cui*, De-Ming Kong*, DNA tetrahedron-enhanced catalytic hairpin assembly for in situ monitoring of viral RNA in host cells. Chemistry - A European Journal, 2025, e202501329.
12. Zhi-Qi Dai, Sha Lu, Zhen-Tong Shen, Qing-Nan Li, Gui-Mei Han, Jin-Ming Liu, Yan Huang, Hao Zheng, Yi Zhang, Guo Chen, Quan Chen*, Yun-Xi Cui*, Li-Na Zhu*, De-Ming Kong*, Intracellular in-situ assembled DNA networks targeting mitochondria enable selective elimination of senescent cells and improve cell viability. Advanced Healthcare Materials, 2025, 2501030.
13. Gui-Mei Han, Jing-Qi Liu, Zhi-Qi Dai, Wei-Liang Jin, Qi-Liang Cai*, De-Ming Kong*, Li-Na Zhu*, Multifunctional cerium-based nanozymes as moonlighting protein mimics for atherosclerosis diagnosis and therapy. Chemical Science, 2025. 16, 8772-8782.
14. Zhi-Li Yao, Qing-Nan Li, Yong-Ji Li, Hao-Rui Li, Si-Wei Yang, Chen-Yu Wang, Jia-Yi Shi, Shun-Li Wu, Shuang-Qing Liu, Gui-Mei Han, Jing Wang, Li-Yong Xing, Yan Zhao*, De-Ming Kong*, Qi-Liang Cai*, CRISPR/Cas12a-based fluorescence-colorimetric dual-mode strategy for sensitive detection of clear cell renal cell carcinoma biomarker miR-210–3p. Sensors and Actuators B-Chemistry, 2025, 440, 137923.
15. Yun-Jie Zhou, Jing-Qi Liu, Dong-Xiao Cao, Xue-Nan Feng, An-Na Tang*, Hong-Xin Jiang*, De-Ming Kong*, Acriflavine-based ionic covalent organic frameworks for adsorption-assisted photocatalytic reduction of hexavalent chromium. Chemical Engineering Journal, 2025, 512, 162634.
16. Feng-Ying Wang, Hong-Xia Zhang, Sheng-Hua Ma, De-Ming Kong*, Peng-Peng Hao*, Li-Na Zhu*, Quercetin sensitized covalent organic framework for boosting photocatalytic H2O2 production and antibacterial. Journal of Colloid and Interface Science, 2025, 693, 137593.
17. Qing-Nan Li, Yun-Xi Cui, Zhi-Qi Dai, Zhi-Li Yao, Man-Ying Li, Qi-Liang Cai*, De-Ming Kong*, Activator strand modifications in CRISPR/Cas12a: Unlocking the potential for Casp-3-targeted biosensing and imaging analysis of apoptosis. Analytical Chemistry, 2025, 97, 4194-4201.
18. Xue-Nan Feng, Xiao-Yang Liu, Dong-Xiao Cao, Yun-Jie Zhou, Yun-Xi Cui*, De-Ming Kong*, “Turn-on” mode fluorescence detection of amines based on a cationic covalent organic framework linked with C-C single bond. Journal of Hazardous Materials, 2025, 489, 137617.
19. Chang-Hao Jiang, Yong-Hui Li, Yue Yuan, Chen-Yu Wang, Jun-Qing Chu, Gui-Mei Han, De-Ming Kong*, Qi-Liang Cai*, Li-Na Zhu*, Octa-cationic porphyrin-functionalized biocompatible nanocomposite: A promising candidate for enhanced combinatorial photodynamic and photothermal tumor therapy. Journal of Medicinal Chemistry, 2025, 68, 3409-3419.
20. Hong-Zhi Zhou, Wei-Liang Jin, Xue-Qian Gan, Chen-Yang Xin, Yun-Zhang Lv, Ming-Jing Xiao, Hai-Yun Shen, De-Ming Kong*, Li-Na Zhu*, In situ growth of COFs within cork for oil-water separation: A comprehensive chemistry experiment for undergraduates. Journal of Chemical Education, 2024, 101, 4306-4314.
21. Wei-Liang Jin, Shao-Cong Li, Hong-Zhi Zhou, Sheng-Hua Ma, Li-Na Zhu*, De-Ming Kong*, Pore wall engineered polar COFs as size-matched nanotraps enable highly efficient capture of long-chain alkylamines. Advanced Functional Materials, 2024, 34, 2406834.
22. Qing-Nan Li, Dong-Xia Wang, Zhi-Qi Dai, Shun-Li Wu, Gui-Mei Han, Sha Lu, Li-Na Zhu*, Hong-Xin Jiang, De-Ming Kong*, Conformational transformation of activator strand directly regulates CRISPR/Cas12a system activity for live cell sensing of multiple biomolecules. Chemical Engineering Journal, 2024, 494, 153084.
23. Hao Zheng, Xue-Nan Feng, Xiang-Wan-Er Jin, Zhi-Qi Dai, Sha Lu, Yun-Xi Cui*, De-Ming Kong*, Multifunctional DNA nanoflower applied for high specific photodynamic cancer therapy in vivo. ChemBioChem, 2024, e202400229.
24. Gui-Mei Han, Bo Liu, Chen-Yu Wang, Dong-Xia Wang, Qing-Nan Li, Qi-Liang Cai*, De-Ming Kong*, Diagnosis and vulnerability risk assessment of atherosclerotic plaques using an amino acid-assembled near-infrared ratiometric nanoprobe. Analytical Chemistry, 2024, 96, 10380-10390.
25. Zi-Lu Li, Ai-Xin Ma, Jing-Qi Liu, Kun Wang, Bao-Cun Zhu*, Dai-Wen Pang*, De-Ming Kong*, A translocation fluorescent probe for analyzing cellular physiology parameters in neurological disease. Journal of Materials Chemistry B, 2024, 12, 4398-4408.
26. Zi-Lu Li, Gui-Mei Han, Kun Wang, Jia-Ao Lyu, Zi-Wen Li, Bao-Cun Zhu*, Li-Na Zhu*, De-Ming Kong*, Multi-parameter assessment of foam cell formation progression using a dual-color switchable fluorescence probe. Analytical Chemistry, 2024, 96, 6968-6977.
27. Qing-Nan Li, Ai-Xin Ma, Dong-Xia Wang, Zhi-Qi Dai, Shun-Li Wu, Sha Lu, Li-Na Zhu*, Hong-Xin Jiang, Dai-Wen Pang*, De-Ming Kong*, Allosteric activator-regulated CRISPR/Cas12a system enables biosensing and imaging of intracellular endogenous and exogenous targets. Analytical Chemistry, 2024, 96, 6426-6435.
28. Wei-Liang Jin, Shao-Cong Li, Hong-Zhi Zhou, Sheng-Hua Ma, Li-Na Zhu*, Hong-Xin Jiang, De-Ming Kong*, A key to crystallinity and reusability of covalent organic frameworks: Adsorption-induced deformation. ACS Materials Letters, 2024, 6, 1474-1483.
29. Sheng-Hua Ma, Wei-Liang Jin, Hong-Xia Zhang, Shao-Cong Li, De-Ming Kong*, Li-Na Zhu*. Polar peripheral substituent-regulated organic/inorganic hybrid photocatalysts promoting the degradation of phenolic pollutants. Journal of Environmental Chemical Engineering, 2024, 12, 112347.
30. Dong-Xia Wang, Bo Liu, Gui-Mei Han, Qing-Nan Li, De-Ming Kong*, Jörg Enderlein*, Tao Chen*, Metal-induced energy transfer (MIET) imaging of cell surface engineering with multivalent DNA nanobrushes. ACS Nano, 2024, 18, 5409-5417.
31. Qing-Nan Li, Dong-Xia Wang, Dan-Ye Chen, Jia-Ao Lyu, Ya-Xin Wang, Shun-Li Wu, Hong-Xin Jiang*, De-Ming Kong*, Photoactivatable CRISPR/Cas12a sensors for biomarkers imaging and point-of-care diagnostics. Analytical Chemistry, 2024, 96, 2692-2701.
32. Hong-Xia Zhang, Sheng-Hua Ma, Hai-Xian Wang, Shao-Cong Li, Hai-Yun Shen, De-Ming Kong*, Feng-Ying Wang*, Li-Na Zhu*. Covalently linked MOF@COF direct Z-scheme heterojunction for visible light-driven photocatalytic degradation of flotation agents. Journal of Environmental Chemical Engineering, 2024, 12, 111899.
33. Shao-Cong Li, Wei-Liang Jin, Hong-Xin Jiang, Hong-Xia Zhang, De-Ming Kong*, Li-Na Zhu*, Efficient removal of phenanthrene by covalent organic frameworks: An experimental combined with theoretical analysis. Separation and Purification Technology, 2024, 336, 126189.
34. Dong-Xiao Cao, Yun-Jie Zhou, Hong-Xin Jiang, Xue-Nan Feng, Xiao-Yang Liu, Wei Li, Jing-Qi Liu, An-Na Tang*, De-Ming Kong*, Always positive covalent organic nanosheet enabling pH-independent adsorption and removal of Cr(VI). Journal of Hazardous Materials, 2024, 465, 133420.
35. Wei Li, Yue-Lei Hao, Wei-Liang Jin, Jing-Qi Liu, An-Na Tang, Li-Na Zhu*, Hong-Xin Jiang*, De-Ming Kong*, Monolithic melamine foam@COF composite: Preparation, characterization and applications in ultrafast removal and on-site quick assessment of Cd2+ pollution. Journal of Cleaner Production, 2024, 434, 140163.
36. Bo Liu, Gui-Mei Han, Dong-Xia Wang, Ding-Bin Liu, An-An Liu, Jing Wang*, Yu-Ling Xiao*, Lin Yuan, De-Ming Kong*, Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis. Chemical Engineering Journal, 2024, 479, 147515.
37. Qiu-Ge Zhao, Yun-Jie Zhou, Dong-Xiao Cao, An-Na Tang*, De-Ming Kong*, DNA-functionalized porphyrinic metal–organic framework-based drug delivery system for targeted bimodal cancer therapy. Journal of Medicinal Chemistry, 2023, 66, 15370-15379.
38. Gui-Mei Han, Bo Liu, De-Ming Kong*, Li-Na Zhu*, DNA as highly biocompatible carriers for drug delivery. Materials Chemistry Frontiers, 2023, 7, 6345-6365.
39. Yun-Jie Zhou, Jing Zhang, Dong-Xiao Cao, An-Na Tang*, De-Ming Kong*, Telomerase-activated Au@DNA nanomachine for targeted chemo-photodynamic synergistic therapy. RSC Medicinal Chemistry, 2023, 14, 2268-2276.
40. Qing-Nan Li, Dong-Xia Wang, Gui-Mei Han, Bo Liu, An-Na Tang*, De-Ming Kong*, Low-background CRISPR/Cas12a sensors for versatile live-cell biosensing. Analytical Chemistry, 2023, 95, 15725-15735.
41. Sheng-Hua Ma, Wei-Liang Jin, Wei Li, Hai-Yuan Wang, Li-Na Zhu*, Ming Zeng*, De-Ming Kong*, Plasmonic Bi/COF nanoheterojunctions for visible-light photodegradation of phenolic pollutants. ACS Applied Nano Materials, 2023, 6, 14151-14164.
42. Wei Li, Xiao-Han Wang, Jing-Qi Liu, Hong-Xin Jiang, Dong-Xiao Cao, An-Na Tang*, De-Ming Kong*, Efficient food safety analysis for vegetables by a heteropore covalent organic framework derived silicone tube with flow-through purification. Talanta, 2023, 265, 124880
43. Bo Liu, Jia-Yi Ma, Jing Wang, Dong-Xia Wang, An-Na Tang, De-Ming Kong*, Rolling-circle-amplification-assisted DNA biosensors for sensitive and specific detection of hypochlorous acid and myeloperoxidase. Chemistry, 2023, 5, 1454-1464.
44. Xiao-Bo Yang, Wei Li, Ze-Zhong Lin, Jing-Qi Liu, Hong-Xin Jiang, Hao Jia, Wei-Liang Jin, Xin-Long Hou, Bing-Xuan Du, Li-Na Zhu*, De-Ming Kong*, Ultralight, robust, and high Prussian blue-loading polyacrylonitrile aerogel: Preparation, characterization and efficient adsorption/removal of Cs+. Chemical Engineering Journal, 2023, 464, 142723.
45. Sha Lu, Zhi-Qi Dai, Yun-Xi Cui*, De-Ming Kong*, Recent development of advanced fluorescent molecular probes for organelle-targeted cell imaging. Biosensors, 2023, 13, 360.
46. Zhan-Chao Li, Wei Li*, Rui Wang, Dong-Xia Wang, An-Na Tang, Xiao-Peng Wang, Xiao-Ping Gao, Gai-Ming Zhao, De-Ming Kong*, Lignin-based covalent organic polymers with improved crystallinity for non-targeted analysis of chemical hazards in food samples. Journal of Hazardous Materials, 2023, 448, 130821.
47. Rui Wang, Hong-Xin Jiang, Hao Jia, Wei Li *, Yan Chen, An-Na Tang, Bing Shao*, De-Ming Kong*, Easily operated COF-based monolithic sponges as matrix clean-up materials for non-targeted analysis of chemical hazards in oil-rich foods. Talanta, 2023, 255, 124250.
48. Wei Li, Wei-Liang Jin, Hong-Xin Jiang, Rui Wang, Hao Jia, Jing-Qi Liu, An-Na Tang, Li-Na Zhu*, De-Ming Kong*, Facile fabrication of hierarchically porous melamine foam@COF composite for sample treatment of non-targeted food safety analysis and oil/water separation. Chemical Engineering Journal, 2023, 455, 140900.
49. Jia-Yi Ma, Bo Liu, Shabib Raza, Hong-Xin Jiang, An-Na Tang, De-Ming Kong*，CRISPR/Cas12a-based hypochlorous acid and myeloperoxidase biosensors designed on RESET effect. Sensors and Actuators B-Chemistry, 2023, 376, 133000.
50. Dong-Xia Wang, Jing Wang*, Ya-Xin Wang, Jia-Yi Ma, Bo Liu, An-Na Tang, De-Ming Kong*, A CRISPR/Cas12a-responsive dual-aptamer DNA network for specific capture and controllable release of circulating tumor cells. Chemical Science, 2022, 13, 10395-10405.
51. Zhan-Chao Li, Wei Li*, Dong-Xia Wang, Rui Wang, An-Na Tang, De-Ming Kong*, Lignin-based hydrogen-bonded covalent organic polymers as functional “switches” of modified atmosphere packaging membranes for preservation of perishable foods. ACS Sustainable Chemistry & Engineering, 2022, 10, 10803-10815.
52. Zong-Ying Li, Bin Yuan, Hai-Xian Wang, Tian-Sheng He, Yan-Long Lan, Si-Yu Wang, Li-Na Zhu*, De-Ming Kong*, Xiao-Zeng Li*, Chiral assembly and recognition of seven copper (II) coordination polymers from tartaric acid derivative ligands. Chemistry-An Asian Journal, 2022, 17, e202200263.
53. Wei-Liang Jin, Xuan Ji, Xin-Long Hou, Shi-Yu Ji, Wei Li, Xi Yu, Xiao-Wei Liu, Li-Na Zhu,* Hong-Xin Jiang*, De-Ming Kong*, Porphyrin COF and its mechanical pressing-prepared carbon fiber hybrid membrane for ratiometric detection, removal and enrichment of Cd2+. Journal of Hazardous Materials, 2022, 439, 129574.
54. Jia-Yi Ma, Si-Yuan Wang, Yi-Chen Du, Dong-Xia Wang, An-Na Tang, Jing Wang*, De-Ming Kong*, “RESET” Effect: Random extending sequences enhance the trans-cleavage activity of CRISPR/Cas12a. Analytical Chemistry, 2022, 94, 8050-8057.
55. Wei-Liang Jin, Wei Li, Hai-Xian Wang, Xiao-Wei Liu, Hong-Xin Jiang*, Li-Na Zhu,* De-Ming Kong*, Sponge-supported monolithic materials of porphyrin covalent organic frameworks for selective recognition, convenient removal and extraction of Cd2+. Journal of Environmental Chemical Engineering, 2022, 10, 107662.
56. Dong-Xia Wang, Ya-Xin Wang, Jing Wang, Jia-Yi Ma, Bo Liu, An-Na Tang, De-Ming Kong*, MnO2 nanosheets as a carrier and accelerator for improved live-cell biosensing application of CRISPR/Cas12a. Chemical Science, 2022, 13, 4364-4371.
57. Wei Li, Hong-Xin Jiang, Meng-Fan Cui, Rui Wang, An-Na Tang, De-Ming Kong*, SiO2 templates-derived hierarchical porous COFs sample pretreatment tool for non-targeted analysis of chemicals in foods. Journal of Hazardous Materials, 2022, 432, 128705.
58. Yan Chen, Wei Li, Rong-Zi Gao, Xiao-Han Wang, An-Na Tang*, De-Ming Kong*, Covalent organic polymers with solid-state dual-color fluorescence tunable by ultraviolet irradiation. Journal of Materials Chemistry C, 2022, 10, 1236-1245.
59. Jing Wang, Dong-Xia Wang, Bo Liu, Xiao Jing, Dan-Ye Chen, An-Na Tang, Yun-Xi Cui*, De-Ming Kong*, Recent advances in constructing higher-order DNA structures. Chemistry-An Asian Journal, 2022, 17, e202101315.
60. Jia-Yi Ma, Ya-Xin Wang, Yan Huang, Yi Zhang, Yun-Xi Cui*, De-Ming Kong*, Chemical-biological approaches for the direct regulation of cell-cell aggregation. Aggregate, 2022, 3, e166.
61. Qiong Wang, Jing Wang, Yan Huang, Yi Zhang, Yun-Xi Cui*, De-Ming Kong*, DNA-based biosensors for high performance in detection of molecular biomarkers: More rapid, sensitive, and universal. Biosensors and Bioelectronics, 2022, 197, 113739.
62. Ya-Xin Wang, Dong-Xia Wang, Jing Wang, Bo Liu, An-Na Tang, De-Ming Kong*, DNA nanolantern-mediated catalytic hairpin assembly nanoamplifiers for simultaneous detection of multiple microRNAs. Talanta, 2022, 236, 122846.
63. Wei Li, Rui Wang, Hong-Xin Jiang, Yan Chen, An-Na Tang, De-Ming Kong*, Controllable synthesis of uniform large-sized spherical covalent organic frameworks for facile sample pretreatment and as naked-eye indicator. Talanta, 2022, 236, 122829.
64. Jing Wang, Jia-Yi Ma, Dong-Xia Wang, Bo Liu, Xiao Jing, Dan-Ye Chen, An-Na Tang, De-Ming Kong*, Oxidative cleavage-based three-dimensional DNA biosensor for ratiometric detection of hypochlorous acid and myeloperoxidase. Analytical Chemistry, 2021, 93, 16231-16239.
65. Si-Yuan Wang, Yi-Chen Du, Dong-Xia Wang, Jia-Yi Ma, An-Na Tang, De-Ming Kong*, Signal amplification and output of CRISPR/Cas-based biosensing systems: A review. Analytica Chimica Acta, 2021, 1185, 338882.
66. Jing Wang, Jia-Yi Ma, Dong-Xia Wang, Bo Liu, An-Na Tang, De-Ming Kong*, Nonenzymatic catalytic assembly of valency-controlled DNA architectures for nanoparticles and live cell assembly. Chemical Communications, 2021, 57, 6760-6763.
67. Xiao-Han Wang, Wei Li, Hong-Xin Jiang, Yan Chen, Rong-Zhi Gao, An-Na Tang*, De-Ming Kong*, Heteropore covalent organic framework-based composite membrane prepared by in situ growth on non-woven fabric for sample pretreatment of food non-targeted analysis. Microchimica Acta, 2021, 188, 235
68. Dong-Xia Wang, Jing Wang, Ya-Xin Wang, Yi-Chen Du, Yan Huang, An-Na Tang, Yun-Xi Cui*, De-Ming Kong*, DNA nanostructure-based nucleic acid probes: construction and biological applications. Chemical Science, 2021, 12, 7602-7622.
69. Wei Li, Rong-Zhi Gao, Hong-Xin Jiang, Qiu-Yu Lu, An-Na Tang, De-Ming Kong*, Metal organic frameworks as sacrificial templates for preparation of hierarchical covalent organic frameworks enabling ultrafast sample treatment in nontargeted food safety analysis. Chemical Engineering Journal, 2021, 425, 130673.
70. Ya-Xin Wang, Dong-Xia Wang, Jia-Yi Ma, Jing Wang, Yi-Chen Du, De-Ming Kong*, DNA nanolantern-based split aptamer probes for in situ ATP imaging in living cells and lighting up mitochondria. Analyst, 2021, 146, 2600-2608.
71. Yan Chen, Wei Li, Xiao-Han Wang, Rong-Zhi Gao, An-Na Tang*, De-Ming Kong*, Green synthesis of covalent organic frameworks based on reaction media. Materials Chemistry Frontiers, 2021, 5, 1253-1267.
72. Ya-Xin Wang, Dong-Xia Wang, Jing Wang, Yi-Chen Du, Yun-Xi Cui, An-Na Tang, Hong-Xin Jiang*, De-Ming Kong*, Reversible assembly/disassembly of DNA frames and applications in logic design, ratiometric sensing and bioimaging. Sensors and Actuators B-Chemistry, 2021, 330, 129335.
73. Yi-Chen Du, Si-Yuan Wang, Ya-Xin Wang, Jia-Yi Ma, Dong-Xia Wang, An-Na Tang, De-Ming Kong*, Terminal deoxynucleotidyl transferase combined CRISPR-Cas12a amplification strategy for ultrasensitive detection of uracil-DNA glycosylase with zero background. Biosensors and Bioelectronics, 2021, 171, 112734.
74. Dong-Xia Wang, Jing Wang, Yi-Chen Du, Jia-Yi Ma, Si-Yuan Wang, An-Na Tang, De-Ming Kong*, CRISPR/Cas12a-based dual amplified biosensing system for sensitive and rapid detection of polynucleotide kinase/phosphatase. Biosensors and Bioelectronics, 2020, 168, 112556.

*以上信息由高级会员个人更新和维护。