马刚

男， 河北大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1989.09-1993.07，南开大学化学系， 本科
1993.09-1996.07，南开大学化学学院，硕士
1996.09-1999.07，北京大学化学与分子工程学院，博士
2000.05-2008.01，美国俄亥俄州立大学化学系博士后及研究助理
2008.02-2010.01，美国耶鲁大学化学系副研究员
2010.01-2023.02，河北大学化学与环境科学学院，教授，博士生导师
2023.03-至今， 河北大学化学与材料科学学院，教授，博士生导师

研究领域和兴趣

振动光谱；和频振动光谱；红外光谱

主要业绩

主要从事振动光谱方面的科研工作。研究中涉及的振动光谱技术主要包括和频振动光谱和红外光谱。在应用振动光谱技术研究界面物理化学和生物物理化学中一些重要问题方面取得了有较高学术水平的成果。作为第一完成人获得了2019年度河北省自然科学三等奖，获奖成果为《振动光谱在分子结构研究中的应用》。从事科研工作以来，在包括 J. Am. Chem. Soc.、J. Phys. Chem. B、Langmuir、PCCP、Chem. Eur. J.、Spectrochim. Acta Part A 等在内的国内外知名期刊上发表论文数十篇，总引用次数3300余次,H指数为27。主持国家自然科学基金面上项目2项和省部级科研项目4项。主要科研成果包括：（1）应用和频振动光谱这一界面敏感的非线性光学光谱技术，研究了水分子在生物膜中的结构，发现了一种新颖的水结构。该水结构发表后获得国内外同行的关注，并被国际同行命名为疏水氢氧根结构。利用和频振动光谱技术研究了DPPC等磷脂分子在生物膜中的结构和相互作用，获得了关于脂类分子的界面有序度和界面取向、头基水化状态以及界面分子间相互作用的重要信息。发展了一种适合对粗糙的气/固界面进行分子结构研究的漫反射和频振动光谱技术。（2）应用红外光谱技术研究了与阿尔茨海默病和帕金森病等疾病相关的淀粉样蛋白纤维化现象。提出了区分淀粉样蛋白纤维平行Beta-折叠构型和反平行Beta-折叠构型的红外光谱判据。发现溶菌酶体系淀粉样蛋白纤维化过程中的非纤维多聚体和纤维化聚集体具有相反的Beta-折叠构型。利用红外光谱探针技术对淀粉样多肽纳米纤维和淀粉样多肽纳米片进行了氨基酸水平上的结构建模，提出了一种千足虫状的淀粉样纳米纤维结构模型和一种倾斜堆叠式的淀粉样纳米片结构模型。提出了一种基于淀粉样蛋白纤维化相图理论的红外差谱方法用于俘获淀粉样蛋白纤维化过程中的中间态多聚体。提出了评估蛋白酰胺I带红外光谱中水汽影响的新判据用于提升蛋白二级结构红外光谱分析的可靠性。应用红外光谱探针技术研究了淀粉样自组装过程的经典和非经典成核机制。应用红外光谱技术研究了苯丙氨酸二肽纳米管的微观结构，提出了其不具备Beta-折叠结构和不是淀粉样自组装体的观点。
热爱教学工作，从教以来积极投身化学专业本科教学改革与实践。在J.Chem.Educ.、《化学教育》、和《实验技术与管理》等期刊上发表教改论文多篇。
学术兼职包括中国光学学会光谱专业委员会委员、《河北大学学报（自然科学版）》英文编辑。
技术专长包括和频振动光谱、红外光谱、超快激光系统搭建。

代表成果

[1] Yang, Lujuan, Wang, Yao, Shang, Peng, Ma, Gang*, Dual-functional synthetic linear and cyclic peptides with anti-amyloid and antimicrobial activities for Alzheimer's disease, Chemistry-A European Journal, 31 (2025) e202404349.

[2] Wang, Yao, Wang, Ziqi, Yang, Lujuan, Liu, Ziyang, Zhang, Chunfang*, Shang, Yanli*, Ma, Gang*, Deciphering the self-assembly mechanisms of three diphenylalanine derivatives using infrared probe technique and scanning electron microscopy, Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 329 (2025) 125522.

[3] Wang, Yao, Wang, Ziqi, Yang, Lujuan, Zhang, Wenkai*, Ma, Gang*, Unravelling the non-classical nucleation mechanism of an amyloid nanosheet through atomic force microscopy and an infrared probe technique, Physical Chemistry Chemical Physics, 26 (2024) 7855-7864.

[4] Li, Yang, Ma, Gang*, Zhu, Lili, Li, Yuanhang, Fu, Jie, Zhang, Lichun, Gong, Kuiliang, Li, Weimin, Guo, Hengyu, Wang, Xiaobo*, Dong, Jun*, From interface effect to bulk effect: Probing the capacitive coupling enhancement mechanism to achieve high performance DC droplet-based nanogenerator, Nano Energy, 127 (2024) 109743.

[5] Li, Yuanhang, Ma, Gang*, Li, Yang, Fu, Jie, Wang, Meishan, Gong, Kuiliang, Li, Weimin, Wang, Xiaobo, Zhu, Lili*, Dong, Jun*, Droplet energy harvesting system based on total-current nanogenerator, ACS Applied Materials & Interfaces, 16 (2024) 27339-27351.

[6] Yang, Lujuan, Wang, Yao, Zhang, Wenkai*, Ma, Gang*, New insight into the structural nature of diphenylalanine nanotube through comparison with amyloid assemblies, Langmuir, 40 (2023) 1046-1057.

[7] Yang, Lujuan, Zhang, Wenkai, Bian, Hongtao, Ma, Gang*, Tutorial on the instrumentation of sum frequency generation vibrational spectroscopy: Using a Ti:Sapphire based system as an example, Biointerphases, 17 (2022) 051201.

[8] Wang, Yao, Jia, Baohuan, You, Min, Fan, Haoran, Cao, Siyu, Li, Hui, Zhang, Wenkai*, Ma, Gang*, Modulation of surface-catalyzed secondary nucleation during amyloid fibrillation of hen egg white lysozyme by two common surfactants, Journal of Physical Chemistry B, 123 (2019) 6200-6211.

[9] Jia, Baohuan, Sun, Ying, Yang, Lujuan, Yu, Yang, Fan, Haoran, Ma, Gang*, A structural model of the hierarchical assembly of an amyloid nanosheet by an infrared probe technique, Physical Chemistry Chemical Physics, 20 (2018) 27261-27271.

[10] Qin, Zhe, Sun, Ying, Jia, Baohuan, Wang, Dan, Ma, Yan, Ma, Gang*, Kinetic mechanism of Thioflavin T binding onto the amyloid fibril of hen egg white lysozyme, Langmuir, 33 (2017) 5398-5405.

[11] Li, Haoyi, Gao, Yachao, Li, Chunxiao, Ma, Gang*, Shang, Yanli*, Sun, Ying, A comparative study of the antibacterial mechanisms of silver ion and silver nanoparticles by Fourier transform infrared spectroscopy, Vibrational Spectroscopy, 85 (2016) 112-121.

[12] Gao, Yachao, Zou, Ye, Ma, Yan, Wang, Dan, Sun, Ying, Ma, Gang*, Infrared probe technique reveals a millipede-like structure for Abeta(8-28) amyloid fibril, Langmuir, 32 (2016) 937-946.

[13] Zou, Ye, Hao, Wenying, Li, Haoyi, Gao, Yachao, Sun, Ying, Ma, Gang*, New insight into amyloid fibril formation of hen egg white lysozyme using a two-step temperature-dependent FTIR approach, Journal of Physical Chemistry B, 118 (2014) 9834-9843.

[14] Zou, Ye, Li, Yiyi, Hao, Wenying, Hu, Xiaoqian, Ma, Gang*, Parallel beta-sheet fibril and antiparallel beta-sheet oligomer: New insights into amyloid formation of hen egg white lysozyme under heat and acidic condition from FTIR spectroscopy, Journal of Physical Chemistry B, 117 (2013) 4003-4013.

[15] Sun, Ying, Zou, Ye, Ma, Gang*, A convenient and cost-effective Fourier transform infrared (FTIR) spectrometer purging setup for the undergraduate teaching laboratory, Journal of Chemical Education, 90 (2013) 950-951.

*以上信息由高级会员个人更新和维护。