许国旺

男， 中国科学院大连化学物理研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1980.9-1984.7 浙江工业大学，分析化学，本科
1984.9-1987.7 中国科学院大连化学物理研究所，分析化学，硕士
1987.9-1991.6 中国科学院大连化学物理研究所，分析化学，博士
1991.6-1994.6 中国科学院大连化学物理研究所，助理研究员
1994.6-1997.10 中国科学院大连化学物理研究所，副研究员，组长
其中：1995.10-1997.9 德国Tuebingen大学高级访问学者
1997.11-现在 中国科学院大连化学物理研究所，研究员，组长
2016.04—2023.11 中国科学院大连化物所生物技术部常务副主任
2017.01—2025.3 中科院分离分析化学重点实验室主任

研究领域和兴趣

复杂样品分离分析方法的创新性研究；代谢组学分析技术平台及其在疾病、中药、植物表型、食品安全等方面应用的研究。

主要业绩

许国旺: 男，博士，研究员。现为中国化学会色谱专业委员会主任、中国化学会理事、中国抗癌协会肿瘤代谢委员会副主任等。2007-2014年曾任J. Chromatogr. B的editor, 现正在担任TrAC的特约编辑和Anal. Chim. Acta, Metabolomics, Anal. Bioanal. Chem.，Metabolites, J. Chromatogr. B等10多个国内外杂志编委。国际高效液相色谱会议（HPLC）科学委员会常委。
许国旺长期致力于色谱及其联用技术的基础理论及应用研究，从1996年始开展“健康和代谢的关系”研究，并逐步进入代谢组学领域。他是我国最早进行代谢组学研究的学者之一，也是国际上此领域的先驱者之一。研究方向是：结合国家重大需求，以生命科学、重大疾病、食品安全等领域的复杂样品分析为切入点，开展极端复杂体系分析的方法学研究、代谢组学方法及其转化医学应用研究等。
其主要业绩为：
一、通过负责承担国家杰出青年基金项目、国家自然科学基金重点项目、国家科技重大专项和国家重大研发计划等国家级科研项目，发展了一系列针对复杂样品分离分析的新方法和装置，极大地提高了色谱-质谱系统的峰容量，使得可分离的组分数从几百变成成千上万；研发了适用于精准医学研究的超灵敏、高覆盖的代谢组学定量、定性综合技术体系；构建了国际领先的代谢组学分析平台，包括建立了一系列高灵敏、高覆盖的新型多维色谱-质谱分析方法、国际上首创拟靶向代谢组学新策略；实现了大规模临床样本代谢组高覆盖精准的分析、自主构建的国内最大的LC-MSn代谢组智能数据库，为代谢物规模化结构鉴定和临床标志物发现提供了新工具。这些分析技术和方法已经应用于生命科学、医学、食品安全等领域重大科学问题的研究，为高校和医院提供至少50个代谢组学研究服务，同时为国内代谢组学学科发展作出贡献。
二、发现了10 多种与肝癌、前列腺癌、卵巢癌及糖尿病等相关的有潜在应用前景的代谢标志物。试剂盒《血清甘胆酸检测试剂盒-液相色谱/串联质谱法》已获批临床医疗器械证（浙械注准20172401284），对推动质谱进临床具有很好的示范意义。
三、在肝衰竭转化医学研究领域取得新进展，揭示了肝衰竭的代谢重编程机制，提出抑制脂肪酸氧化，提高肝细胞再生能力的通过代谢干预治疗肝衰竭的新策略。合作小组在体外和体内模型中发现，曲美他嗪（TMZ）干预后的肝细胞糖酵解增强，有效降低了微环境中肝细胞的凋亡率。在郑州大学附属第一医院的随机临床试验(ChiCTR-OPC-15006839)中证实，使用TMZ治疗肝衰竭患者后，3个月的总体死亡率明显降低。本研究为治疗肝衰竭提供了一种新策略。
四、至今为止，已在PNAS, Nature Protocols, Hepatology, Advanced Science, Diabetes Care, Cancer Res., Clin. Chem., Anal. Chem. 等国际著名杂志发表系列文章，连续6年入选ELSEVIER“中国高被引学者”榜单，申请专利100多件（其中50多件已授权），合著著作5部。

代表成果

代表性文章：
1． Tianrun Xu, Hang Li, Peng Dou, Yuanyuan Luo, Siming Pu, Hua Mu, Zhihao Zhang, Disheng Feng, Xuesen Hu, Ting Wang, Guang Tan, Chuang Chen, Haiyang Li, Xianzhe Shi*, Chunxiu Hu*, Guowang Xu* (2024) Concentric Hybrid Nanoelectrospray Ionization‐Atmospheric Pressure Chemical Ionization Source for High‐Coverage Mass Spectrometry Analysis of Single‐Cell Metabolomics, Adv Sci, 11: e2306659.
2． Lei You#, Jing Kou#, Mengdie Wang#, Guoqin Ji#, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu*, Surong Mei*, Guowang Xu* (2024) An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population, Nat Commun,15(1):2268
3． Yueqiong Ni#, Lingling Qian#, Sara Leal Siliceo#, Xiaoxue Long#, Emmanouil Nychas, Yan Liu, Marsena Jasiel Ismaiah, Howell Leung, Lei Zhang, Qiongmei Gao, Qian Wu, Lina Zhou, Xiaolin Wang, Qi Li, Hani El-Nezami, Aimin Xu, Guowang Xu*, Huating Li*, Gianni Panagiotou*, Weiping Jia* (2023) Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations, Cell Metab., 35, 1530–1547.
4． Zhen Ning#, Xin Guo#, Xiaolong Liu#, Chang Lu#, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan*, Guowang Xu*, Hai-long Piao* (2022) USP22-dependent accumulation of lipidomes drives hepatocellular carcinoma progression by stabilizing PPARγ, Nat. Commun., 13(1): 2187.
5． Lei You, Fujian Zheng, Chang Su, Limei Wang, Xiang Li, Qianqian Chen, Jing Kou, Xiaolin Wang, Yanfeng Wang, Yuting Wang, Surong Mei, Bing Zhang*, Xinyu Liu*, Guowang Xu* (2022) Metabolome-wide association study of serum exogenous chemical residues in a cohort with 5 major chronic diseases, Environment International, 158, 106919
6． Wenying Liang, Fujian Zheng, Tiantian Chen, Xiuqiong Zhang, Yueyi Xia, Zaifang Li, Xin Lu, Chunxia Zhao*, Guowang Xu* (2022) Nontargeted Screening Method for Veterinary Drugs and Their Metabolites Based on Fragmentation Characteristics from Ultrahigh-Performance Liquid Chromatography–High-Resolution Mass Spectrometry, Food Chem. 369, 130928
7． Saleh Alseekh*, Asaph Aharoni, Yariv Brotman, Kévin Contrepois, John D'Auria, Jan Ewald, Jennifer C Ewald , Paul D Fraser, Patrick Giavalisco, Robert D Hall , Matthias Heinemann , Hannes Link, Jie Luo, Steffen Neumann , Jens Nielsen, Leonardo Perez de Souza, Kazuki Saito, Uwe Sauer, Frank C Schroeder, Stefan Schuster, Gary Siuzdak, Aleksandra Skirycz, Lloyd W Sumner, Michael P Snyder, Huiru Tang , Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, Alisdair R. Fernie* (2021) Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices, Nature Methods, 18(7):747-756
8． Tianrun Xu, Hang Li, Disheng Feng, Xianzhe Shi, Chunxiu Hu*, Guowang Xu* (2021) Lipid profiling of 20 mammalian cells by capillary microsampling combined with high-resolution spectral stitching nanoelectrospray ionization direct-infusion mass spectrometry, Anal. Chem. 93, 10031−10038
9． Mengmeng Chang, Qingqing Wang, Xinyu Liu*, Xianzhe Shi*, Guowang Xu* (2021) Facile Synthesis of Antibody-Coupled Polydopamine Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria, Anal. Chem., 93, 11099−11107
10． Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8): 2519-2537
11． Di Yu, Yang Liu, Yiqiang Zhou, Guowang Xu*, Chunzhang Yang* (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A, 117(18):9964-9972.
12． Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.
13． Qiuhui Xuan#, Yang Ouyang#, Yanfeng Wang#, Liang Wu#, Huating Li, Yuanyuan Luo, Xinjie Zhao, Disheng Feng, Wangshu Qin, Chunxiu Hu, Lina Zhou, Xinyu Liu, Haidong Zou, Chun Cai, Jiarui Wu*, Weiping Jia*, Guowang Xu* (2020) Applications of Multi-Platform Metabolomics in Studying Metabolic Pathway Dysregulation and Discovering Novel Serum Metabolite Biomarkers to Identify Diabetic Retinopathy Subjects from Patients with Diabetes, Advanced Science, 2020, 7, 2001714.
14． Wangjie Lv, Lichao Wang, Qiuhui Xuan, Xinjie Zhao, Xinyu Liu, Xianzhe Shi *, Guowang Xu * (2020) Pseudotargeted Method based on Parallel Column Two-Dimensional Liquid Chromatography-Mass Spectrometry for Broad Coverage of Metabolome and Lipidome, Anal. Chem., 92(8):6043-6050
15． Xinyu Liu#, Lina Zhou#, Xianzhe Shi, Guowang Xu* (2019) New advances in analytical methods for mass spectrometry-based large-scale metabolomics study, TrAC-Trend Anal. Chem., 121, 115665
16． Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675
17． Di Yu, Lina Zhou, Qiuhui Xuan, Lichao Wang, Xinjie Zhao, Xin Lu, Guowang Xu* (2018) Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography—High-Resolution Mass Spectrometry, Anal. Chem., 90(9):5712-5718.
18． Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819
19． Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908
20． Rui Wu, Zeming Wu, Xianhui Wang, Pengcheng Yang, Dan Yu, Chunxia Zhao, Guowang Xu*, Le Kang* (2012) Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts, Proc Natl Acad Sci U S A, 109(9):3259-63

*以上信息由高级会员个人更新和维护。