伍新燕

女， 华东理工大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1988.9-1992.7，武汉大学化学系，本科学生
1992.9-1997.10，武汉大学化学系，硕博连读研究生
1997.10-2001.8，华东理工大学精细化工研究所，讲师、副教授
2001.8-2003.11，美国科罗拉多州立大学化学系，博士后
2003.11-至今，华东理工大学精细化工研究所，副教授、教授

研究领域和兴趣

有机合成方法学

主要业绩

原创性设计合成了基于手性环己烷骨架的双/多功能叔膦类催化剂和天然氨基酸衍生的双功能叔膦类催化剂，在不对称催化Morita-Baylis-Hillman反应、Rauhut-Currier反应、烯丙基烷基化等反应中获得了高对映选择性；首次高产率、高对映选择性地实现了手性叔磷催化的不对称Rauhut-Currier反应；原创性设计了以吡唑酰胺为活化基团的γ-亲核试剂，成功地实现了手性叔胺催化其插烯aldol-环化串联反应、插烯Michael加成-环化串联反应等；以手性环己烷骨架的叔膦-铜配合物为催化剂，高选择性地实现了二乙基锌对缺电子共轭二烯烃的1,4-加成反应、酮亚胺的Mannich反应、羰基化合物的炔基化反应。

代表成果

1. Ying Fan, Jian Lu, Feng Sha, Qiong Li, Xin-Yan Wu, Cu(I)-catalyzed asymmetric Mannich Reaction of glycine Schiff bases to ketimines, Journal of Organic Chemistry, 84 (18) (2019), DOI: 10.1021/acs.joc.9b01566.
2. Jian Lu, Ying Fan, Feng Sha, Qiong Li, Xin-Yan Wu, Copper-catalyzed enantioselective Mannich reaction between N-acylpyrazoles and isatin-derived ketimines, Organic Chemistry Frontiers, 6 (15) (2019), DOI: 10.1039/c9qo00575g.
3. Jian Lu, Ling-Shan Luo, Feng Sha, Qiong Li, Xin-Yan Wu, Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes, Chemical Communications, 55 (77) (2019), DOI: 10.1039/c9cc05252f.
4. Rukeya Rexiti, Zhen-Guo Zhang, Jian Lu, Feng Sha, Xin-Yan Wu, Regioselective and enantioselective Cu(II)-catalyzed 1,4-conjugate addition of diethylzinc reagent to nitrodienes, Journal of Organic Chemistry, 84 (3) (2019), DOI: 10.1021/acs.joc.8b02798.
5. Tian-Chen Kang, Lu-Ping Wu, Qi-Wen Yu, Xin-Yan Wu, Enantioselective Rauhut-Currier-type 1,6-conjugate addition of methyl vinyl ketone to para-quinone methides, Chemistry-A European Journal, 23 (27) (2017), DOI: 10.1002/chem.201700520.
6. Tian-Ze Li, Jin Xie, Yu Jiang, Feng Sha, Xin-Yan Wu, Enantioselective vinylogous Michael/cyclization cascade reaction of acyclic β,γ-unsaturated amides with isatylidene malononitriles: asymmetric construction of spirocyclic oxindoles, Advanced Synthesis & Catalysis, 357 (16-17) (2015), DOI: 10.1002/adsc.201500469.
7. Tian-Ze Li, Yu Jiang, Yu-Qing Guan, Feng Sha, Xin-Yan Wu, Direct enantioselective vinylogous aldol-cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole-dihydropyranones, Chemical Communications, 50 (74) (2014), DOI: 10.1039/c4cc04235b.
8. Tian-Ze Li, Xi-Bo Wang, Feng Sha, Xin-Yan Wu, Organocatalyzed enantioselective Mannich reaction of pyrazoleamides with isatin-derived ketimines, Journal of Organic Chemistry, 79 (10) (2014), DOI: 10.1021/jo500145w
9. Jing-Jing Gong, Tian-Ze Li, Kun Pan, Xin-Yan Wu, Enantioselective intramolecular Rauhut-Currier reaction catalyzed by chiral phosphinothiourea, Chemical Communications, 47 (5) (2011), DOI: 10.1039/c0cc04412a.
10. Hong-Liang Song, Kui Yuan, Xin-Yan Wu, Chiral phosphine-squaramides as enantioselective catalysts for the intramolecular Morita-Baylis-Hillman reaction, Chemical Communications, 47 (3) (2011), DOI: 10.1039/c0cc03187a.

*以上信息由高级会员个人更新和维护。