张骥

男， 四川大学化学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1993-09 至 1997-07, 四川大学, 物理化学, 本科在读
1997-09 至 2002-06, 四川大学, 有机化学, 博士在读
2002-07 至 2007-06, 四川大学化学学院, 讲师
2003-01 至 2005-01, 香港大学化学系, 助理研究员
2007-07 至 2013-06, 四川大学化学学院, 副教授
2013-07 至 今, 四川大学化学学院, 教授

研究领域和兴趣

化学生物学、有机化学

主要业绩

教授，博士生导师。2002年于四川大学化学学院获理学博士学位，师从谢如刚教授。之后历任香港大学Research Assistant（支志明教授课题组）、四川大学化学学院讲师、副教授、教授。入选教育部“新世纪优秀人才支持计划”，第十三批四川省学术和技术带头人后备人选。从事有机化学、化学生物学教学科研工作，国家级一流本科课程《有机化学（I）》负责人，主编“十四五”普通高等教育本科国家级规划教材1部，教育部化学“101”计划骨干教师。曾获四川大学“姜维平优秀教学奖”、“五粮春青年教师优秀教学奖”、十佳青年教师、“探究式-小班化”教学竞赛一等奖等多项教学奖励。科研方向为纳米生物材料，作为项目负责人获4项国家自然科学基金、1项重点研发项目子课题、2项四川省自然科学基金等资助，获教育部高等学校科研成果一等奖1项，以第一作者/通讯作者发表SCI论文100余篇，主编英文专著1部。

代表成果

主编著作：
1.《有机化学基础》（第三版），2020，科学出版社。ISBN: 978-7-03-064996-6.
2.<Macrocyclic Polyamines: Synthesis and Applications>, 2018, Wiley-VCH, ISBN: 978-3-527-34187-0.

近年代表性论文（2020~）：
1.Lei, Y.; Sun, S.; Wang, R.; Zhang, J.* “Multifunctionally Modified Low molecular Weight PEI for Efficient Gene Delivery and Ferroptosis-Induced Antitumor Activity” Biomacromolecules 2026, 27(5), 3292-3302.
2.Tian, X.-L.; Chen, P.; Hu, Y.; Zhang, L.; Li, J.; Zhang, J.* “Bacterial outer membrane vesicles encapsulated cationic polymer with STING agonist as nanovaccines for enhanced immunotherapy” Chem. Eng. J. 2025, 521, 166687.
3.Zhang, Q.-F.; Zhao, R.-M.; Lei, Y.; Tian, X.-L.; Hu, Y.; Zhang, L.; Zhang, J.* “Cinnamaldehyde-Based ROS-responsive polymeric gene vectors for efficient gene delivery and tumor cell growth inhibition” Biomacromolecules 2025, 26(2), 1362-1371.
4.Hu, Y.; He, X.; Chen, P.; Tian, X.-L.; Wang, R.; Song, X.-R.*; Yu, X.-Q.; Zhang, J.* “Lung-Targeted Delivery of PTEN mRNA Combined with anti-PD-1-mediated Immunotherapy for In Situ Lung Cancer Treatment” Acta Biomater. 2025, 194, 442-454.
5.Tian, X.-L.; Chen, P.; Hu, Y.; Zhang, L.; Yu, X.-Q.; Zhang, J.* “Enhanced gene transfection ability of sulfonylated low molecular weight PEI and its application in anti-tumor immunotherapy” J. Mater. Chem. B 2024, 12(46), 12111-12123.
6.Yang, H.-Z.; Hu, Y.; Chen, J.-J.; Zhao, R.-M.; Pu, L.; Yu, X.-Q.; Zhang, J.* “Nitric Oxide / PDT combination therapy by the Fluorescent Self-reporting Co-delivery Platforms” J. Drug Deliv. Sci. Technol. 2024, 92, 105296.
7.Zhan, Y.-R.; Huang, Z.-Y.; He, X.; Tian, M.-M.; Li, G.-H.; Chen, P.; Yu, X.-Q.; Song, X.-R.*; Zhang, J.* “A Fluoropolymer as Protein Delivery Vector with Potent Adjuvant Effect for Immunotherapy” J. Mater. Chem. B 2023, 11(37), 8933-8942.
8.Chen, P.; He, X.; Hu, Y.; Tian, X.-L.; Yu, X.-Q.; Zhang, J.* “Spleen-targeted mRNA delivery based on polyamine carbon dots for tumor immunotherapy” ACS Appl. Mater. Interf. 2023, 15(16), 19937-19950.
9.Yang, H.-Z.; Guo, Y.; Pu, L.; Yu, X.-Q.; Zhang, J.* “Fluorescent self-reporting lipid nanoparticles for NO / gene co-delivery and combination therapy” Mol. Pharm. 2023, 20(2), 1404-1414.
10.Guo, Y.; He, X.; Zhao, R.-M.; Yang, H.-Z.; Huang, Z.; Zhang, J.*; Yu, X.-Q.* “Zn-dipicolylamine-based reactive oxygen species-responsive lipids for siRNA delivery and in vivo colitis treatment” Acta Biomater. 2022, 147, 287-298.
11.Zhan, Y.-R.; Chen, P.; He, X.; Hei, M.-W.; Zhang, J.*; Yu, X.-Q.* “Sodium alginate-doping cationic nanoparticle as dual gene delivery system for genetically bimodal therapy” Biomacromolecules 2022, 23(12), 5312-5321.
12.Zhan, Y.-R.; Tan, J.; Hei, M.-W.; Zhang, S.-Y.; Zhang, J.*; Yu, X.-Q.* “Construction of GSH-triggered cationic fluoropolymer as two-in-one nanoplatform for combined chemo/gene therapy” J. Mater. Chem. B 2022, 10(8), 1308-1318.
13.Chen, P.; He, X.; Zhang, J.*; Tian, X.-L.; Yu, X.-Q.* “One-Step Fabrication of Functional Carbon Dots with Long Wavelength Emission for Gene Delivery and Bio-imaging” J. Mater. Chem. B 2021, 9(40), 8518-8529.
14.Chen, P.; Zhang, J.*; He, X.; Liu, Y.-H.; Yu, X.-Q.* “Hydrophobically Modified Carbon Dots as Multifunctional Platform for Serum-Resistant Gene Delivery and Cell Imaging” Biomater. Sci. 2020, 8(13), 3730-3740.
15.Xiao, Y.-P.; Zhang, J.*; Liu, Y.-H.; Huang, Z.; Yu, X.-Q.* “Fluorinated polymer emulsion systems: Construction and application in delivering gene and proteins” Eur. J. Med. Chem. 2020, 207, 112799.

专利：
1.一种用于mRNA 递送的中性脂质、二组分脂质纳米颗粒、制备方法及应用，张骥、胡越、陈平、余孝其，专利号202511200543.2。
2.一种阳离子脂质化合物及其制备方法和应用，张骥、陈嘉嘉、王蓉、郭钰，专利号202310891187.8。
3.环氧化合物与阳离子聚合物及它们的制备方法，余孝其、张琴芳、张骥，专利号201210586561.5。

*以上信息由高级会员个人更新和维护。