童爱军

女， 清华大学化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

(1) 1979.9–1983.7, 新疆大学化学系, 学士
(2) 1983.8-1985.3, 新疆大学化学系, 助教
(3) 1985.3-1986.1, 东北师范大学留日预备校, 日语学习
(4) 1986.7-1987.3, 日本明星大学化学系, 公派留学生
(5) 1987.4–1992.3, 日本明星大学化学系, 博士, 导师: TANAKA Shigeyuki 田中诚之
(6) 1992.4至今，清华大学化学系，讲师、副教授、教授

研究领域和兴趣

分析化学，荧光探针

主要业绩

长期从事与生命分析相关的发光分析理论及应用研究工作，是国内较早并持续进行该领域的研究者之一。近年主要从事发光性功能试剂的合成与生物分子的分子识别分析，在荧光传感器及功能发光材料的研究领域进行了深入系统的研究。相关研究成果包括: (1) 设计合成了多种新型且具有良好分析应用前景的聚集诱导荧光及刺激响应荧光分子，用于环境、生命相关重要分析物的高灵敏度、高选择性检测、活细胞荧光成像以及防伪、紫外光强测量等方面，相关工作在J. Am. Chem. Soc. 2014; Anal. Chem. 2017; Chem.Comm. 2017; Chem.-Eur. J. 2019, 2016; J. Org. Chem. 2009; J. Phys. Chem. C 2011, 2013, 2017; ACS Appl. Mater. Interfaces 2016; J. Mater. Chem. 2011 等期刊上发表。其中，基于水杨醛席夫碱的聚集诱导发光分子由本课题组于2009 年首次报道，基于其易于化学修饰、合成简单、发光机理明确，Stokes 位移大的独特优点，已被国内外多个课题组进行了深入研究，也已用于活细胞成像。(2)建立了非标记的功能脱氧核糖核酸传感系统，实现了非荧光标记法检测重金属和有机小分子代谢物（J. Am. Chem. Soc., 2009; Anal. Chem. 2012；Anal. Chem. 2014；Chem. Commun.2015）。(3) 设计合成了多种络合型或反应型金属离子荧光传感器、pH 荧光传感器、酶荧光传感器等，建立了高选择性高灵敏度金属离子的荧光增强型、比率型检测方法和细胞成像方法，相关工作在Org. Lett. 2006；Chem.Comm. 2010；J. Mater. Chem. 2011；J. Phys. Chem. B 2015, 2018 等期刊上发表。

代表成果

1. Lu Peng; Ruirui Wei; Yifei Guo; Xiaokun Zheng; Yue Zheng; Yiwen Ding; Yu Xiang; Aijun Tong, Tuning Emission Wavelength of Polymorphous Crystal via Controllable Alkyl Chain Stacking and Its Vapor- and Thermo-Responsive Fluorescence, Chem. Eur. J., 2019, 25: 8043~8052
2. Lu Peng; Lu Xiao; Yiwen Ding; Yu Xiang; Aijun Tong, A simple design of fluorescent probes for indirect detection of b-lactamase based on AIE and ESIPT processes, J. Mater. Chem. B, 2018, 6: 3922~3926
3. Lu Peng; Shidang Xu; Xiaokun Zheng; Xiamin Cheng; Ruoyu Zhang; Jie Liu; Bin Liu; Aijun Tong, Rational design of a red-emissive fluorophore with AIE and ESIPT characteristics and its application in light-up sensing of esterase, Anal. Chem., 2017, 89: 3162~3168
4. Yue Zheng; Xiaokun Zheng; Lu Peng; Yu Xiang; Aijun Tong, Photoactivatable aggregation-induced emission of triphenylmethanol, Chem. Comm., 2017, 53:11130~11133
5. Xiaokun Zheng; Yue Zheng; Lu Peng; Yu Xiang; Aijun Tong, Mechanoresponsive fluorescence of 2-aminobenzophenone derivatives based on amorphous phase to crystalline transformation with high “off−on” contrast ratio, J. Phys. Chem. C, 2017, 127: 21610~21615
6. Kai Li; Yu Xiang; XiaoyanWang; Ji Li; Rongrong Hu; Aijun Tong; Ben Zhong Tang, Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex, J. Am. Chem. Soc., 2014, 136: 1643~1649
7. Panshu Song; Xiaotong Chen; Yu Xiang; Lei Huang; Zhaojuan Zhou; Ruirui Wei; Aijun Tong, A ratiometric fluorescent pH probe based on aggregation-induced emission enhancement and its application in live-cell imaging, J. Mater. Chem., 2011, 21: 13470~13475
8. Weixin Tang; Yu Xiang; Aijun Tong, Salicylaldehyde azines as fluorophores of aggregation-induced emission enhancement characteristics, J. Org. Chem., 2009, 74: 2163~2166
9. Yu Xiang; Aijun Tong; Yi Lu, Abasic site-containing DNAzyme and aptamer for label-free fluorescent detection of Pb2+ and adenosine with high sensitivity, selectivity, and tunable dynamic range, J. Am. Chem. Soc., 2009, 131: 15352~15357
10. Yu Xiang; Aijun Tong, A New Rhodamine-Based Chemosensor Exhibiting Selective FeIII-Amplified Fluorescence, Org. Lett., 2006, 8, 1549-1552

*以上信息由高级会员个人更新和维护。