梁琼麟

男， 清华大学化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1996-09~2000-07 清华大学 化学系 化学专业 理学学士
2000-09~2005-07 清华大学 化学系 分析化学 理学博士
2005-08~2015-12 清华大学 化学系 讲师，副教授
2013-01~至今 清华大学 国家中医药管理局中药化学三级实验室主任
2015-04~至今 清华大学 化学系党委书记
2016-01~2020-12 清华大学化学系 长聘副教授
2019-01~至今 清华大学 清华大学中药研究院副院长
2020.12~至今 清华大学化学系 长聘教授

研究领域和兴趣

分析化学 （微流控、药物分析、生命分析、药品质量与安全、中药现代化、质谱、色谱）

主要业绩

梁琼麟教授以微流控芯片及其与质谱、光谱联用分析技术为基础，发展生命分析与药物分析新方法，开发生物医用新材料新器件，发明器官类器官芯片新模型，致力于服务国家药品质量与安全、新药创制以及中药现代化研究与开发。近年来重点聚焦于器官类器官芯片、单细胞亚细胞分析及基于质谱的多组学分析等。曾主持完成国家重大科技专项第一个微流控芯片药物研发关键技术项目，在器官芯片核心关键技术及血管、肝、肾、肠等器官芯片模型研究方面取得重要进展。2017-2022年间，以通讯作者在Nat. Protoc., Adv. Mater., Adv. Funct. Mater., Adv. Sci., Anal. Chem., Lab. Chip.等重要学术期刊上发表SCI论文100余篇，以第一发明人申请发明专利25余项（授权15项）。工作以来累计发表SCI论文250余篇，授权发明专利30余项，合著专著5部。部分研究成果已在制药企业、临床医院得到广泛应用，曾合作获得国家科技进步二等奖3项。入选2020年度教育部“长江学者奖励计划”特聘教授、2013年度教育部新世纪优秀人才计划与北京高校青年英才计划。担任中国医药生物技术协会药物分析技术分会秘书长，中国分析测试协会青委会副主任委员，中国中药协会中药产品开发与培育专业委员会副主任委员与北京理化分析测试技术学会副理事长兼青委会理事长等学术兼职。

代表成果

1. Wu L, Ai YJ, Xie RX, Xiong JL, Wang Y*, Liang QL*. Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models. Lab on a chip, 2023, DOI: 10.1039/D2LC00804A.
2. Guan LD, Hu WT, Zuo H, Sun H, Ai YJ, He MQ, Ma C*, Ding MY*, Liang QL*. An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging. Chemical Communications, 2023, DOI: 10.1039/D2CC06354A.
3. Lu ZH, Jiang X, Yi Q, Xiong JL, Han Q*, Liang QL*. Metal-Polyphenol Network-Mediated Protein Encapsulation Strategy Facilitating the Separation of Proteins and Metabolites in Biospecimens. Analytical Chemistry, 2023, 95, 581–586.
4. Ai YJ, Hu, Z N, Liang XP*, Sun, HB, Xin HB*, Liang QL*. Recent Advances in Nanozymes: From Matters to Bioapplications. Advanced Functional Materials, 2022, 32(14), 2110432.
5. Sun H, He Y, Wang ZH*, Liang QL*. An Insight of Skeletal Networks Analysis for Smart Hydrogels. Advanced Functional Materials, 2022, 32 (6), 2108489.
6. Ai YJ, Sun H, Wang CL, Zheng WC, Han Q, Liang QL*. Tunable Assembly of Organic-Inorganic Molecules into Hierarchical Superstructures as Ligase Mimics for Enhancing Tumor Photothermal Therapy. Small, 2022, 18 (10), 2105304.
7. Wang CL, Gao XH, Zhang F, Hu WT, Gao ZX, Zhang YQ, Ding M, Liang QL*. Mussel Inspired Trigger-Detachable Adhesive Hydrogel. Small, 2022, 18(21), 2200336.
8. Zheng WC, Xie RX, Liang XP*, Liang QL*. Fabrication of Biomaterials and Biostructures Based On Microfluidic Manipulation. Small, 2022, 18 (16), 2105867.
9. Hu ZN, Ai YJ, Xu WJ, Zhang XY, Sun ZJ, Guo LT, Guo RX, Wang YM, Ding KL, Sun HB*, Hu JS, Liang QL*, Yang Y*. Iron Catalyzed Cascade Construction of Molybdenum Carbide Heterointerfaces for Understanding Hydrogen Evolution. Small, 2022, 18 (18), 2200439.
10. Sun ZJ, Sun S, Jiang X, Ai YJ, Xu WJ, Xie LP, Sun HB*, Liang QL*. Oligo-layer graphene stabilized fully exposed Fe-sites for ultra-sensitivity electrochemical detection of dopamine. Biosensors & Bioelectronics, 2022, 211, 114367.
11. Xiong JL, Wang Y, Jiang X, Liang XP*, Liang QL*. Kinetically Orthogonal Probe for Simultaneous Measurement of H2S and Nitroreductase: A Refined Method to Predict the Invasiveness of Tumor Cells. Analytical Chemistry, 2022, 94 (3), 1769-1777.
12. Ai YJ, Sun H, Gao ZX, Wang CL, Guan LD, Wang YP, Wang Y, Zhang HY, Liang QL*. Dual Enzyme Mimics Based on Metal-Ligand Cross-Linking Strategy for Accelerating Ascorbate Oxidation and Enhancing Tumor Therapy. Advanced Functional Materials, 2021, 31 (40), 2103581.
13. Ai YJ, You JZ, Gao JY, Wang JP, Sun HB, Ding MY, Liang QL*. Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation. Nano Research, 2021, 14 (8), 2644-2653.
14. Wang CL, Chai Y, Wen XD, Ai YJ, Zhao H, Hu WT, Yang XP, Ding MY, Shi XL, Liu QF, Liang QL*. Stretchable and Anisotropic Conductive Composite Hydrogel as Therapeutic Cardiac Patches. ACS Materials Letters, 2021, 3(8), 1238-1248.
15. Xie RX, Liang Z, Ai YJ, Zheng WC, Xiong JL, Xu PD, Liu YP, Ding MY, Gao JY, Wang Jiaping, Liang QL*. Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes. Nature Protocols, 2021, 16, 937-964.
16. Xiong JL, Xie RX, Wang Y, Wang CL, Ai YJ, Zheng WC, Ding MY, Gao JY, Wang JP, Liang QL*. Nitrite-Responsive Hydrogel: Smart Drug Release Depending on the Severity of the Nitric Oxide-Related Disease. ACS Applied Materials & Interfaces, 2020, 12, 51185-51197.
17. Xie RX, Korolj A, Liu C, Song X, Lu R, Zhang BY, Ramachandran A, Liang QL*. Radisic M*. h-FIBER: Microfluidic topographical hollow fiber for studies of glomerular filtration barrier. ACS Central Science, 2020, 6(6), 903-912.
18. Xie RX, Zheng WC, Guan LD, Ai YJ, Liang QL*. Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues. Small, 2020, 16(15), 1902838.
19. Ai YJ, Xie RX, Xiong JL, Liang QL*. Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells. Small, 2020, 16(9),1903940.
20. Xiong Jl, Xie RX, Wang Y, Wang CL, Ai YJ, Zheng WC, Ding MY, Gao JY, Wang JP, Liang QL*. Nitrite-Responsive Hydrogel: Smart Drug Release Depending on the Severity of the Nitric Oxide-Related Disease. ACS Applied Materials & Interfaces, 2020, 12, 51185
21. Li JF, Liu L, Ai YJ, Liu Y, Sun HB*, Liang QL*. Self-Polymerized Dopamine-Decorated Au NPs and Coordinated with Fe-MOF as a Dual Binding Sites and Dual Signal-Amplifying Electrochemical Aptasensor for the Detection of CEA. ACS Applied Materials & Interfaces, 2020, 12(5), 5500-5510
22. Ai YJ, Hu ZN, Liu L, Zhou JJ, Long Y, Li JF, Ding MY, Sun HB*, Liang QL*. Magnetically Hollow Pt Nanocages with Ultrathin Walls as a Highly Integrated Nanoreactor for Catalytic Transfer Hydrogenation Reaction. Advanced Science, 2019, 6 (7), 1802132.
23. Wang Y, Shao ZX, Zheng WC, Xie YY, Luo GA, Ding MY, Liang QL*. A 3D construct of the intestinal canal with wrinkle morphology on a centrifugation configuring microfluidic chip. Biofabrication, 2019, 11 (4), 045001.
24. Ai YJ, Zhang F, Wang CL, Xie RX, Liang QL*. Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test. TrAC-Trends in Analytical Chemistry, 2019, 117, 215-230.
25. Xie RX, Xu PD, Liu YP, Li LL, Luo GA, Ding MY, Liang QL*. Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process. Advanced Materials, 2018, 30, 1705082.
26. Zhang F, Xiong LG, Ai YJ, Liang Z, Liang QL*. Stretchable Multi-responsive Hydrogel with Actuatable, Shape memory and Self-healing Properties. Advanced Science, 2018, 5, 1800450.
27. Li LL, Li YQ, Shao ZX, Luo GA, Ding MY, Liang QL*. Simultaneous Assay of Oxygen-Dependent Cytotoxicity and Genotoxicity of Anticancer Drugs on an Integrated Microchip. Analytical Chemistry, 2018, 90(20), 11899-11907.
28. Ma LD, Wang YT, Wang JR, Wu JL, Meng XS, Hu P, Mu X, Liang QL*, Luo GA*. Design and Fabrication of a Liver-on-a-chip Platform for Convenient, Highly Efficient, and Safe in Situ Perfusion Culture of 3D Hepatic Spheroids. Lab on a Chip, 2018, 18, 2547-2562.
29. Yang SH, Zhang FF, Liang QL*, Wang ZH*. A Three-Dimensional Graphene-Based Ratiometric Signal Amplification Apta sensor for MUC1 Detection. Biosensors & Bioelectronics, 2018, 120, 85-92.
30. Yang SH, Zhang FF, Wang ZH*, Liang QL*. A Graphene Oxide-based Label-free Electrochemical Aptasensor for the Detection of Alpha-fetoprotein. Biosensors & Bioelectronics, 2018, 112, 186-192.
31. Xu PD, Xie RX, Liu YP, Li LL, Luo GA, Ding MY, Liang QL*. Bioinspired Microfibers with Embedded Perfusable Helical Channels. Advanced Materials, 2017, 29, 1701664.

*以上信息由高级会员个人更新和维护。