付华

男， 清华大学化学系， 教授/研究员/教授级高工或同等级别

学习/工作经历

1985.09–1989.07 武汉大学分析测试科学系，本科学生
1995.02–1998.03 清华大学化学系，博士生
1989.08–1998.12 北京微量化学研究所, 助理研究员
1999.1–至今 清华大学化学系，先后任讲师、副教授、教授

研究领域和兴趣

有机化学、化学生物学

主要业绩

(1) 建立了多种含磷化合物合成新方法；(2) 建立了新颖、高效的铜催化剂体系，实现了芳环上官能团(氨基、羟基、硝基、磺酰基、羧基等)的转化；(3) 建立了铜催化C-H键功能化构建C-N、C-O、C-C键的新方法；(4) 建立了铜催化合成喹唑啉、喹唑啉酮、苯并咪唑、苯并噻嗪、咪唑啉酮、吲哚、异喹啉酮等多种杂环化合物的新方法；(5) 研发出了多种具有新颖、高效的轴手性配体，高对映选择性的用于不对称合成中；(6) 建立了多种可见光催化有机合成的新方法；(7) 研发出了细胞膜通透性较好、活性较高的磷杂香豆素类和醛类蛋白酪氨酸磷酸酯酶抑制剂；(8) 发展了核苷多聚磷酸酯与不保护的氨基酸、肽、氨基核苷和氨基糖反应构建了核苷－氨基酸、核苷－肽、核苷－糖缀合物等化合物的新方法；(9) 建立了生物大分子的生物正交连接与剪切新方法。

代表成果

1. Youshan Li, Zhenbang Lou, Hongyun Li, Haijun Yang, Yufen Zhao, Hua Fu*, Bioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with ortho-Dithiophenols. Angewandte Chemie, International Edition 2020, 59(9), 3671-3677.
2. Yunhe Jin, Lunyu Ou, Haijun Yang, Hua Fu*, “Visible-Light-Mediated Aerobic Oxidation of N-Alkylpyridinium Salts under Organic Photocatalysis” J. Am. Chem. Soc. 2017, 139(40), 14237-14243.
3. Min Jiang, Haifang Li, Haijun Yang, Hua Fu*, “Room-Temperature Arylation of Thiols: Breakthrough with Aryl Chlorides” Angew. Chem. Int. Ed. 2017, 56(3), 874-879.
4. Pengxiang Zhang, Jipan Yu, Fei Peng, Xudong Wu, Jiyang Jie, Can Liu, Hua Tian, Haijun Yang, Hua Fu*, “Development of Axially Chiral Cyclo-Biaryldiol Ligands with Adjustable Dihedral Angles” Chem. Eur. J. 2016, 22(48), 17477-17484.
5. Hua Tian, Pengxiang Zhang, Fei Peng, Haijun Yang, Hua Fu*, “Chiral Cyclic Ligand-Enabled Iridium-Catalyzed Asymmetric Arylation of Unactivated Racemic Allylic Alcohols with Anilines” Org. Lett. 2017, 19(14), 3775-3778.
6. Fei Peng, Hua Tian, Pengxiang Zhang, Can Liu, Xudong Wu, Xi Yuan, Haijun Yang, Hua Fu*, “Iridium-Catalyzed Enantioselective Synthesis of Dihydroimidazoquinazolinones by Elaborate Tuning of Chiral Cyclic Ligands” Org. Lett. 2017, 19(23), 6376-6379.
7. Xi Yuan, Xudong Wu, Pengxiang Zhang, Fei Peng, Can Liu, Haijun Yang, Changjin Zhu, Hua Fu*, Axially Chiral Cyclic Phosphoric Acid Enabled Enantioselective Sequential Additions. Org. Lett. 2019, 21(8), 2498-2503.
8. Jie Zhao, Yufen Zhao, Hua Fu* “Transition-Metal-Free Intramolecular Ullmann-Type O-Arylation: Synthesis of Chromone Derivatives”Angew. Chem. Int. Ed. 2011, 50(16), 3769-3773.
9. Honghua Rao, Hua Fu*, Yuyang Jiang, Yufen Zhao, "Easy Copper-Catalyzed Synthesis of Primary Aromatic Amines by Coupling Aromatic Boronic Acids with Aqueous Ammonia at Room Temperature" Angew. Chem. Int. Ed. 2009, 48(6), 1114-1116.
10. Xiaowei Liu, Hua Fu*, Yuyang Jiang, Yufen Zhao, “A Simple and Highly Efficient Approach to Quinazolinones under Mild Copper-Catalyzed Conditions” Angew. Chem. Int. Ed. 2009, 48(2), 348-351.

*以上信息由高级会员个人更新和维护。