肖伟烈

男， 云南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1. 1995.09 ～ 1999.07 淮北煤炭师范学院，本科学生
2. 1999.09 ～ 2002.07 南京农业大学，硕士研究生，植物学
3. 2002.09 ～ 2005.07 中国科学院昆明植物研究所， 博士研究生， 天然有机化学
4. 2005.08 ～ 2006.07 中国科学院昆明植物研究所， 助理研究员， 天然有机化学
5. 2006.07 ～ 2011.12 中国科学院昆明植物研究所， 副研究员， 天然有机化学
6. 2008.09 ～ 2010.07 美国Memorial Sloan Kettering Cancer Center 博士后，天然有机化学
7. 2012.01 ～ 2016.10 中国科学院昆明植物研究所， 研究员，天然有机化学
8. 2016.10 ～ 至今 云南大学 研究员，天然有机化学

研究领域和兴趣

天然药物化学及化学生物学

主要业绩

申请人曾获国家优青、云南省云岭学者及科技部重大新药创制等重要项目支持，聚焦西部特色药物资源的天然产物研究：①完成了100余种西部地区药用植物的系统研究，分离并改造获得5000余个化合物，其中新化合物1181个，新骨架50个；②获得新型抗HIV病毒功能分子“二苯胺酯”及靶向PD-1/PD-L1肿瘤免疫功能分子Xci-2等多个候选药物分子；③完成了抗HIV候选药物分子“二苯胺酯”成药性评价以及“益母草注射液”化学物质基础鉴定和质量标准提升；④针对天然产物生物活性的高效率发现及深度挖掘的技术瓶颈问题，创新性地开展了基于人工智能的天然药物化学研究，率先针对炎症性疾病构建了天然产物抗炎免疫活性数据库并开展了化学信息学研究。以第一或通讯作者发表高水平论文105篇。申请人聚焦西部特色药用植物资源，借助人工智能技术等多学科融合交叉，重点研究天然来源的抗病毒及免疫调节先导分子的发现及功能评价。具体成果体现如下：
1. 天然药物资源中新型结构天然小分子的发现为新药研发提供分子模板
围绕天然药物资源中新类型、新结构的天然产物的发现和活性研究，对马鞭草科、 益母草属、五味子科等 100 余种药用植物的化学成分进行了研究，发现了 1181 个新的结构，尤其发现了具有多种骨架类型的 190 余个高氧化度、结构新奇的降三萜类化合物。连续不断地发现了系列新的骨架和新类型的天然分子，并首次提出“Schisandra nortriterpenoids（五味子降三萜）”概念； 从马鞭草科植物黄毛豆腐柴中及从中药泽漆中分离得到系列结构新颖的二萜化合物 (Org. Lett. 2020, doi.org/10.1021/acs.orglett.0c02676; Org. Lett. 2018, 20, 6314–6317）。研究成果在不同领域的渗透影响力广泛，引文涉及 43 个学科，50 个国家及地区，568 多所国内外高等学府和研究机构，主要分布在化学、药理学、植物科学等学科领域。发表的新颖天然产物，由于结构的独特性、 创新性，被天然产物化学丛书《三萜化学》《现代天然产物化学》以及《高速发展的中国化学》等书籍所引用和评价。
2. 基于分子靶标和信号通路的新颖天然产物创新发现及活性评价
天然产物的“结构多样性”是其“生物活性多样性”产生的化学基础，通过对课题组的天然产物分子库针对药物靶标、细胞信号通路、疾病模型等进行研究，取得系列创新研究成果，发现了抗肝癌、抗HIV、抑制NLRP3炎症小体活化的作用、调节蛋白泛素化降解以及雌激素合成调节的功能小分子，部分研究成果在 Journal of Medicinal Chemistry, Org Lett, Sci Rep, J Nat Prod 等杂志上公开发表，获得了专利进行知识产权的保护。
3. 创新性地开展基于人工智能的天然活性分子研究
对如何高效开展天然药物物质基础和功能分子快速发现的方法学进行了创新性探索研究。首次构建了天然产物抗炎活性数据库并开展了系统性的化学信息学研究（J. Chem. Inf. Model. 2019, 59, 66-73）。在天然产物权威评述期刊Nat Prod Rep上发表文章，对基于机器学习的天然产物活性研究的进展进行了综述，并结合本团队的研究经验，提出了一系列研究建议，拟在数据科学家和药物研究者之间架设一道有效沟通的桥梁（Nat. Prod. Rep., 2021, 38, 346-361）。借助人工智能药物发现技术，发现靶向PD-1/PD-L1的抗肿瘤免疫皂苷类化合物并开展了潜在应用评价。
在完成为本科生和研究生授课工作的基础上，重要成果在国际学术期刊 Nat Prod Rep, Org Lett, Chem Eur J, J Nat Prod 等杂志上共发表 206 篇研究结果；以第一和通讯或共同通讯作者共发表成果105 篇，影响因子>5.0 的 17 篇；申报了系列专利对研究成果进行了知识产权的保护。
获得中国化学会青年化学奖、中科院西部学者突出贡献奖、中国药学会施维雅青年药物化学奖、云南省青年科技红河奖、以及中科院卢嘉锡青年人才工作奖等10余项奖励和荣誉。

代表成果

1. Wei-Lie Xiao, Rong-Tao Li, Sheng-Xiong Huang, Jian-Xin Pu, Han-Dong Sun*, Triterpenoids from the Schisandraceae family, Nat. Prod. Rep., 2008, 25, 871-891. (IF 10.715)
2. Wei-Lie Xiao, Hua-Jie Zhu, Yun-Heng Shen, Rong-Tao Li, Sheng-Hong Li, Han-Dong Sun*, Yong-Tang Zheng, Rui-Rui Wang, Yang Lu, Cheng Wang, Qi-Tai Zheng, Lancifodilactone G: A unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity, Org. Lett., 2005, 7(11), 2145-2148. (IF 6.142)
3. Wei-Lie Xiao, Rong-Tao Li, Sheng-Hong Li, Xiao-Li Li, Han-Dong Sun*, Yong-Tang Zheng, Rui-Rui Wang, Yang Lu, Cheng Wang, Qi-Tai Zheng, Lancifodilactone F: A novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity, Org. Lett., 2005, 7(7), 1263-1266. (IF 6.142)
4. Wei-Lie Xiao, Liu-Meng Yang, Ning-Bo Gong, Li Wu, Rui-Rui Wang, Jian-Xin Pu, Xiao-Li Li, Sheng-Xiong Huang, Yong-Tang Zheng, Rong-Tao Li, Yang Lu, Qi-Tai Zheng, Han-Dong Sun*, Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities, Org. Lett., 2006, 8(5), 991-994. (IF 6.142)
5. Wei-Lie Xiao, Jian-Xin Pu, Ying Chang, Xiao-Li Li, Sheng-Xiong Huang, Liu-Meng Yang, Li-Mei Li, Yang Lu, Yong-Tang Zheng, Rong-Tao Li, Qi-Tai Zheng, Han-dong Sun*, Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera, Org. Lett., 2006, 8(7), 1475-1478. (IF 6.142)
6. Wei-Lie Xiao, Chun Lei, Jie Ren, Tou-Gen Liao, Jian-Xin Pu, Charles U. Pittman Jr., Yang Lu, Yong-Tang Zheng, Hua-Jie Zhu*, Han-Dong Sun*, Structure elucidation and theoretical investigation of key steps in the biogenetic pathway of schisanartane nortriterpenoids by using DFT methods, Chem. Eur. J., 2008, 14(36), 11584-11592. (IF 5.696)
7. Pu, D. B.; Du, B. W.#; Chen, W.; Gao, J. B.; Hu, K.; Shi, N.; Li, Y. M.; Zhang, X. J.; Zhang, R. H.; Li, X. N.; Zhang, H. B.; Wang, F.*; Wei-Lie Xiao* Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva, Organic Letters, 2018, 20(19), 6314-6317.
8. Yi-Ming Shi, Jie Yang, Li Xu, Xiao-Nian Li, Shan-Zhai Shang, Peng Cao*, Wei-Lie Xiao*, and Han-Dong Sun*, Structural Characterization and Antioxidative Activity of Lancifonins: Unique Nortriterpenoids from Schisandra lancifolia, Organic Letters, 2014, 16, 1370−1373 (IF = 6.142)
9. Xiao LUO; Shi, Y. M.; Luo, R. H.; Luo, S. H.; Li, X. N.; Wang, R. R.; Li, S. H.; Zheng, Y. T.; Du, X.; Xiao, W. L.*; Pu, J. X.; Sun, H. D*. Schilancitrilactones A-C: Three Unique Nortriterpenoids from Schisandra lancifolia. Organic Letters 2012, 14, 1286-1289. (IF 6.142)
10. Yi-Ming SHI; Wang, X. B.; Li, X. N.; Luo, X.; Shen, Z. Y.; Wang, Y. P*.; Xiao, W. L.*; Sun, H. D.*, Lancolides, Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.0]undecane-Bridged System from Schisandra lancifolia. Organic Letters 2013, 15 (19), 5068-5071. (IF 6.142)
11. Cheng-Qin Liang; Shi, Y. M.; Luo, R. H.; Li, X. Y.; Gao, Z. H.; Li, X. N.; Yang, L. M.; Shang, S. Z.; Li, Y.; Zheng, Y. T.; Zhang, H. B.; Xiao, W. L.*; Sun, H. D.* Kadcoccitones A and B, Two Novel 6/6/5/5-fused Tetracyclic Triterpenoids from Kadsura coccinea. Organic letters 2012, 14 (24), 6362-5. (IF 6.142)
12. Yi-Ming Shi, Xing-Yao Li, Xiao-Nian Li, Xiao Luo, Yong-Bo Xue, Cheng-Qin Liang, Juan Zou, Ling-Mei Kong, Yan-Li, Jian-Xin Pu, Wei-Lie Xiao*, Han-Dong Sun*, Schicagenins A-C: three cagelike nortriterpenoids from leaves and stems of Schisandra chinensis, Organic Letters, 2011, 13(15), 3848-3851. (IF 6.142)
13. Ming-Hong Liao,1 Meng Zhang,1 Dai-Hui Hu, Rui-Han Zhang, Yan Zhao, Shan-Shan Liu, Yun-Xia Li, Wei-Lie Xiao,* and E Tang*.Controlling the selectivity of an intramolecular Friedel-Crafts alkylation with alkenes using selenium under mild conditions.Org. Biomol. Chem.2020,(2020 IF= 3.49)DOI:10.1039/D0OB00257G.
14. Yan-Ling Tang,1Xi Zheng,1Yan Qi, Xiao-Jia Pu, Bei Liu, Xia Zhang, Xiao-Si Li, Wei-Lie Xiao*, Chun-Ping Wan*, Ze-Wei Mao*,Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors. Bioorganic Chemistry. 2020,98, 103748.(2020 IF=3.926 )
15. Rui-han Zhang, Xiao-li Li, Xing-jie Zhang, Hua-yan Qin and Wei-lie Xiao*，Machine learning approaches for elucidating the biological effects of natural products, Nat. Prod. Rep., 2021, 38, 346-361.
16. Qiang-qiang Shi, Xing-jie Zhang, Ting-ting Wang, Qi Wang, Tian-tian Sun, Muhammad Amin, Rui-han Zhang, Xiao-li Li,* and Wei-lie Xiao*, Euphopias A−C: Three Rearranged Jatrophane Diterpenoids with Tricyclo[8.3.0.02,7] tridecane and Tetracyclo [11.3.0.0 2,10.0 3,7] hexadecane Cores from Euphorbia Helioscopia, Org. Lett., 2020, 22, 7820-7824.
17. De-bing Pu, Xing-jie Zhang, De-wen Bi, Jun-bo Gao, Yan Yang, Xiao-li Li,* Jing Lin, Xiao-nian Li, Rui-han Zhang, and Wei-Lie Xiao*，Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from Callicarpa Plants Blocking NLRP3 Inflammasome-Induced Pyroptosis, J. Nat. Prod. 2020, 83, 2191-2199.
18. Jun-bo Gao, Xing-jie Zhang, Kun Shang, Wei-mao Zhong, Rui-han Zhang, Xiao-chang Dai, Xiao-li Li*, Qi Wang, Yan Zou, Wei-lie Xiao*, Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation, Chinese Chemical Letters, 2020,31,427-430.
19. De-bing Pu, Bao-wen Du, Wen Chen, Jun-bo Gao, Kun Hu, Nan Shi, Yi-ming Li, Xing-jie Zhang, Rui-han Zhang, Xiao-nian Li, Hong-bin Zhang, Fei Wang, and Wei-lie Xiao*, Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva, Org. Lett., 2018, 20, 6314−6317.
20. Wei-Lie Xiao, Yan-Qing Gong, Rui-Rui Wang, Zhi-Ying Weng, Xiao Luo, Xiao-Nian Li, Fei He, Jian-Xin Pu, Liu-Meng Yang, Yong-Tang Zheng, Yang Lu, Han-Dong Sun*, Bioactive nortriterpenoids from Schisandra grandiflora, J. Nat. Prod., 2009, 72(9), 1678–1681. (IF 3.947)
21. Wei-Lie Xiao, Shi-Ying Yang, Liu-Meng Yang, Guang-Yu Yang, Rui-Rui Wang, Hai-Bo Zhang, Wei Zhao, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng and Han-Dong Sun*, Chemical constituents from the leaves and stems of Schisandra rubriflora, J Nat Prod., 2010, 73(2), 221-225. (IF 3.947)
22. Wei-Lie Xiao, Ren-Rong Tian, Jian-Xin Pu, Xian Li, Li Wu, Yang Lu, Sheng-Hong Li, Rong-Tao Li, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun*，Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity, J. Nat. Prod., 2006, 69(2), 277-279. (IF 3.947)
23. Wei-Lie Xiao, Sheng-Xiong Huang, Li Zhang, Ren-Rong Tian, Li Wu, Xiao-Li Li, Jian-Xin Pu, Yong-Tang Zheng, Yang Lu, Rong-Tao Li, Qi-Tai Zheng, Han-Dong Sun*, Nortriterpenoids from Schisandra lancifolia, J. Nat. Prod., 2006, 69(4), 650-653. (IF 3.947)
24. Wei-Lie Xiao, Xiao-Li Li, Rui-Rui Wang, Liu-Meng Yang, Li-Mei Li, Sheng-Xiong Huang, Jian-Xin Pu, Yong-Tang Zheng, Rong-Tao Li, Han-Dong Sun*, Triterpenoids from Schisandra rubriflora, J. Nat. Prod., 2007, 70(6), 1056-1059. (IF 3.947)
25. Xiao-Nian Li, Jian-Xin Pu, Xue Du, Liu-Meng Yang, Hui-Mei An, Chun Lei, Fei He, Xiao Luo, Yong-Tang Zheng, Yang Lu, W Wei-Lie Xiao*, Han-Dong Sun*, Lignans with anti-HIV activity from Schisandra propinqua var. sinensis, J. Nat. Prod., 2009, 72(6), 1133-1141. (IF 3.947)
26. Guang-Yu Yang, Yin-Ke Li, Rui-Rui Wang, Xiao-Nian Li , Wei-Lie Xiao*, Liu-Meng Yang, Jian-Xin Pu , Yong-Tang Zheng, Han-Dong Sun*, Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities, J. Nat. Prod., 2010, 73(5), 915-919. (IF 3.947)
27. Guang-Yu Yang, Rui-Rui Wang, Huai-Xue Mu, Yin-Ke Li, Xiao-Nian Li , Liu-Meng Yang, Yong-Tang Zheng, Xiao, W. L.* and Han-Dong Sun* Dibenzocyclooctadiene Lignans and Norlignans from Fruits ofSchisandra wilsoniana, J. Nat. Prod., 2013, 76 (2), 250-255. (IF 3.947)
28. Xue-Mei Gao, Jian-Xin Pu, Sheng-Xiong Huang, Liu-Meng Yang, Hao Huang, Wei-Lie Xiao*, Yong-Tang Zheng, Han-Dong Sun*, Lignans from Kadsura angustifolia, J. Nat. Prod., 2008, 71(4), 558-563. (IF 3.947)
29. Xue-Mei Gao; Wang, R. R.; Niu, D. Y.; Meng, C. Y.; Yang, L. M.; Zheng, Y. T.; Yang, G. Y.; Hu, Q. F.*; Sun, H. D.; Xiao, W. L.*, Bioactive Dibenzocyclooctadiene Lignans from the Stems of Schisandra neglecta. J. Nat. Prod. 2013, 76,1052-1057. (IF 3.947)
30. Cheng-Qin LIANG; Shi, Y. M.; Li, X. Y.; Luo, R. H.; Li, Y.; Zheng, Y. T.; Zhang, H. B.; Xiao, W. L.*; Sun, H. D.*, Kadcotriones A-C: tricyclic triterpenoids from Kadsura coccinea. Journal of natural products 2013, 76 (12), 2350-2354. (IF 3.947)
31. Zhi-Ke Liu, Da-Rong Wu, Yi-Ming Shi, Ting Zeng, Shao-Hua Liu, Xue Du, Yong-Jun Dang*, Wei-Lie Xiao*, Han-Dong Sun，Three new diterpenoids from Leonurus japonicus，Chinese Chemical Letters，25 (2014) 677–679
32. Zhong, Wei-Mao; Cui, Zhao-Meng; Liu, Zhi-Ke; Yang, Yan; Wu, Da-Rong; Liu, Shao-Hua; Long, Hui; Sun, Han-Dong; Dang, Yong-Jun(*); Xiao, Wei-Lie(*), Three minor new compounds from the aerial parts of Leonurus japonicus, Chinese Chemical Letters, 2015, (26): 1000~1003
33. Gao, J. B., Yang, S. J., Yan, Z. R., Zhang, X. J., Pu, D. B., Wang, L. X., Li, X. L., Zhang, R. H.*, Xiao, W. L.* Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors, J. Nat. Prod., 2018, 81(4), 998-1006.
34. Debing Pu, Xiaoning Li, Jing Lin, Ruihan Zhang,Ting Luo, Yuan Wang, Junbo Gao,Muhammad Aurang Zeb, Xingjie Zhang, Xiaoli Li*, Ruirui Wang*, and Weilie Xiao*.Triterpenoids from Ganoderma gibbosum: A Class of Sensitizers of FLC-Resistant Candida albicans to Fluconazole.Journal of Natural Products.2019,82(8),2067-2077.(2019 IF= 4.257)
35. Junbo Gao, Xingjie Zhang, Kun Shang, Weimao Zhong, Ruihan Zhang, Xiaochang Dai, Xiaoli Li,*, Qi Wang, Yan Zou, Weilie Xiao*.Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation. Chinese Chemical Letters.2020,31,427-430. (2020 IF= 3.839)
36. De-Bing Pu,1 Xing-Jie Zhang,1 De-Wen Bi,1 Jun-Bo Gao, Yan Yang, Xiao-Li Li,* Jing Lin, Xiao-Nian Li,Rui-Han Zhang, and Wei-Lie Xiao*，Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from Callicarpa Plants Blocking NLRP3 Inflammasome-Induced Pyroptosis. Journal of Natural Products，2020, 83, 2191−2199.（2020 IF=3.779）
37. Xing-Jie Zhang,1 Wei-Mao Zhong,1 Rui-Xue Liu,1 Yong-Mei Wang, Ting Luo, Yan Zou, Hua-Yan Qin, Xiao-Li Li,* Ruihan Zhang,* and Wei-Lie Xiao*，Structurally Diverse Labdane Diterpenoids from Leonurus japonicus and Their Anti-inflammatory Properties in LPS-Induced RAW264.7 Cells. Journal of Natural Products,2020, 83, 2545−2558.（2020IF=3.779）
38. 《化学中毒与急救》，科学出版社，主编汤峨，副主编张洪彬，肖伟烈，2021年10月
39. 肖伟烈，王飞，普德兵，杜宝文，张芮菡，史楠，高俊博，张兴杰，一类异海松烷型二萜衍生物，其药物组合物及其用途，中国专利号：ZL201810592573.6，公告日：2021.02.02
40. 肖伟烈，张芮菡，高俊博，杨双静，张兴杰，普德兵，李晓莉，一类松香烷型二萜衍生物与其药物组合物和用途，中国专利号：ZL201810028568.2，公告日：2020.09.08

*以上信息由高级会员个人更新和维护。