钱兆生

男， 浙江师范大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999.9-2003.7 山东师范大学 化学与材料科学学院 化学学士学位
2003.9-2006.7 新疆大学 化学化工学院 有机化学硕士学位
2006.9-2009.7 南京大学 化学化工学院 化学博士学位
2009.8-至今 浙江师范大学 化学与生命科学学院 教授
2013.4-2014.4 华盛顿大学（西雅图）化学系 访问学者

研究领域和兴趣

有机智能材料和分子荧光探针

主要业绩

主要致力于新型功能发光材料和探针的可控制备及其在分析检测新方法和新策略的开发应用研究工作。近年来，在功能发光材料的可控合成、性能调控和生物传感等方面取得了一定的研究进展，并进一步发展了一系列基于能量共振转移、解聚发光、光诱导电子转移和聚集诱导发光等机制的分析检测新方法和新策略，实现了对系列生物活性小分子和疾病标志物的灵敏检测。这些研究成果发表在《Journal of American Chemical Society》、《Chemical Science》、《Chemical Communications》(4篇)、《Advanced Optical Materials》(2篇)、《Analytical Chemistry》(8篇)、《Chemistry-A European Journal》(5篇)、《Journal of Physical Chemistry Letters》(3篇)、《Biosensors and Bioelectronics》(6篇)、《ACS Sensors》、《ACS Applied Materials & Interfaces》(4篇)、《Analyst》(3篇)、《Journal of Materials Chemistry》(13篇)等国际学术刊物上，在《The Chemical Record》(IF 5.4)发表邀请综述一篇。迄今为止，申请人以第一作者或通讯作者发表SCI学术论文72篇，其中影响因子大于5的论文有55篇，高被引论文有2篇，5篇文章被选为封面文章；所发表论文被包括《Chemical Reviews》和《Chemical Society Reviews》等在内的多篇权威综述文章引用评述，h-index 37，单篇最高引用次数为344次，总引用次数近4400余次。
近年来主要在有机室温磷光分子和荧光分子探针的设计合成及应用取得了一些进展。基于具有聚集诱导磷光性质的多取代苯硫醚苯化合物，我们构建了由外在刺激控制的单分子磷光荧光可逆开关体系，该有机磷光分子在聚集状态、去质子化等外在环境调控下可以实现磷光-荧光、荧光-荧光等多重发光的可逆转换，同时通过理论模拟揭示了该类分子聚集诱导磷光性质的内在机制，为相关高效聚集诱导磷光有机体系提供了设计思路(Chem. Eur. J., 2018, 24, 12773；Chem. Eur. J., 2020, 26, 3733)。在室温磷光有机材料方面，我们课题组提出了有机晶体中强电子耦合作用在超长有机磷光晶体中的主导作用，通过四种不同结构的调控和晶体分析，证实了强电子耦合作用导致的超分子行为是产生有机晶体中超长室温磷光的主要原因，为设计高效超长磷光有机材料提供了有效规则(J. Phys. Chem. Lett., 2018, 9, 3939; J. Phys. Chem. Lett., 2018, 9, 6305; J. Mater. Chem. C, 2019, 7, 43; J. Mater. Chem. C, 2019, 7, 14535; J. Phys. Chem. Lett., 2020, 11, 4962)。为了提高四苯乙烯的聚集诱导荧光效率，我们首次发现了四苯乙烯体系的反重原子效应，为设计高效聚集诱导荧光探针提供了研究思路(Chem. Commun., 2019, 55, 14938)；基于经典聚集诱导发光分子骨架四苯乙烯和多芳基噻咯体系，我们提出了反重原子效应，并将其用于大幅提高聚集诱导发光分子的荧光量子效率(Chem. Sci., 2021, 12, 10710 cover paper; Adv. Optical Mater., 2021, 2101228)；同时，通过分子单元设计和调整，构建了高效率的双态发光分子策略(J. Mater. Chem. C, 2021, 9, 12177)，实现了经典四苯乙烯体系从光物理的聚集诱导发光到光化学的单一和多色光致变色的可控切换 (ACS Appl. Mater. Interfaces, 2021, 12, 42410; J. Mater. Chem. C, 2020, 8, 13197; J. Mater. Chem. C, 2021, 9, 8249)。在有机荧光探针的设计合成方面，我们合成了烯键修饰的分子转子荧光探针，利用将烯-巯基点击化学，发展了针对丁酰胆碱酯酶活性检测的新方法; 实现了对细胞膜探针和细胞内钙离子的高选择性成像(Analyst, 2018, 144, 559；Chem. Commun. 2019, 55, 4841；Anal. Chem. 2022, 94, 4048; Anal. Chem. 2022, 94, 5406)。

代表成果

(1) Xiaoxiao Zhang, Zhenni Wang, Hao Chu, Zuping Xiong, Yanjiang Li, Yi Chen, Qiaozhi Zhu, Hui Feng, Engao Zhu, Jin Zhou,* Peng Huang,* Zhaosheng Qian.* Antipermeability strategy to achieve extremely high specificity and ultralong imaging of diverse cell membranes based on restriction-induced emission of AIEgens. Anal. Chem., 2022, 94, 4048-4058.
(2) Zhenni Wang, Zuping Xiong, Weidong Liu, Qiaozhi Zhu, Xiaoxiao Zhang, Yuqing Ding, Chunyan Huang, Hui Feng, Kewei Zhang, Engao Zhu,* Zhaosheng Qian.* Esterase-activated precipitating strategy to achieve highly specific detection and long-term imaging of calcium ions by aggregation-induced phosphorescence probe. Anal. Chem., 2022, 94, 5406-5414.
(3) Zuping Xiong, Zhenni Wang, Longxiang Liu, Mengyi Jiang, Xiaoxiao Zhang, Qiaozhi Zhu, Hui Feng, Zhaosheng Qian.* Breaking classic heavy-atom effect to achieve heavy-atom-induced dramatic emission enhancement of silole-based AIEgens with through-bond and through space conjugation. Adv. Optical Mater., 2021, 9, 2101228.
(4) Zuping Xiong, Xiaoxiao Zhang, Longxiang Liu, Qiaozhi Zhu, Zhenni Wang, Hui Feng Zhaosheng Qian.* Achieving highly efficient aggregation-induced emission, reversible and irreversible photochromism by heavy halogen-regulated photophysics and D-A molecular pattern-controlled photochemistry of through-space conjugated luminogens. Chem. Sci., 2021, 12, 10710-10723.
(5) Sidan Guo, Shasha Zhou, Jiajing Chen, Ping Guo, Riqing Ding, Huili Sun, Hui Feng Zhaosheng Qian.* Photochromism and fluorescence switch of furan-containing tetraarylethene luminogens with aggregation-induced emission for photocontrolled interface-involved applications. ACS Appl. Mater. Interfaces, 2020, 12, 42410-42419.
(6) Pengfei Xu, Qianqian Qiu, Xinru Ye, Mengru Wei, Wenbin Xi, Hui Feng, Zhaosheng Qian.* Halogenated tetraphenylethene with enhanced aggregation-induced emission: anomalous anti-heavy-atom effect and self-reversible mechanochromism. Chem. Commun., 2019, 55, 14938-14941.
(7) Guilin Chen, Zaicai Zhou, Hui Feng, Chenyan Zhang, Yifan Wang, Zhaosheng Qian,* Jianwei Pan.* An aggregation-induced phosphorescence probe for calcium ion-specific detection and live-cell imaging in Arabidopsis thaliana. Chem. Commun., 2019, 55, 4841 - 4844.
(8) Qianqian Qiu, Pengfei Xu, Yanjun Zhu, Junru Yu, Mengru Wei, Wenbin Xi, Hui Feng, Jianrong Chen, Zhaosheng Qian.* Rational design of dual-state emission luminogens with solvatochromism by combining a partially shared donor-acceptor pattern and twisted structures. Chem. Eur. J., 2019, 25, 15983-15987.
(9) Guilin Chen, Hui Feng, Xiaogan Jiang, Jing Xu, Saifei Pan, Zhaosheng Qian*. Redox-controlled fluorescent nanoswitch based on reversible disulfide and its application in butyrylcholinesterase activity assay. Anal. Chem., 2018, 90, 1643-1651.
(10) Cong Tang, Hui Feng, Yuanyuan Huang, Zhaosheng Qian*. Reversible Luminescent Nanoswitches Based on Aggregation-Induced Emission Enhancement of Silver nanoclusters for Luminescence Turn-on Assay of Inorganic Pyrophosphatase Activity. Anal. Chem. 2017, 89, 4994-5002.

*以上信息由高级会员个人更新和维护。