王小兵

男， 中国药科大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1997.09-2001.07，汉中师范学院，化学系，本科学生
2002.09-2005.07，陕西师范大学，化学与环境工程学院，硕士研究生
2005.09-2008.06，中国药科大学，中药学院，博士研究生
2008.07-2011.05，中国药科大学，中药学院，讲师
2011.06-2017.05，中国药科大学，中药学院，副教授
2015.07-2016.08，美国斯克利普斯研究所，访问学者
2017.06-今 中国药科大学，中药学院，教授

研究领域和兴趣

天然药物化学

主要业绩

王小兵，博士，教授，博士生导师，江苏省“六大人才高峰”A类高层次人才（2018年），“333工程”第三层次培养对象（2018年），“青蓝工程”优秀青年骨干教师（2017年），主要从事天然活性成分研究与开发工作。
2008年毕业于中国药科大学，获药物化学专业博士学位。2008年7月留校天然药物化学教研室任教，承担本科生《天然药物化学》、《波谱解析》和研究生《高等波谱解析》等课程教学工作。2015-2016年于美国The Scripps Research Institute的Jin-Quan Yu教授课题组从事有机合成中的碳氢活化及其在天然产物中的应用研究工作。在Science, ACS Catalysis, Journal of Medicinal Chemistry, ACS Applied Materials & Interface, European Journal of Medicinal Chemistry，ACS Chemical Neuroscience, Organic & Biomolecular Chemistry等SCI源刊发表科研论文100余篇，SCI他引共计3268篇次，获10余项发明专利，获得国家自然科学基金面上项目、江苏省自然科学基金面上项目和青年项目等基金支持，参与多项国家和省部级基金项目。

代表成果

1. Cheng Wang, Lailiang Qu, Shang Li, Fucheng Yin, Limei Ji, Wan Peng, Heng Luo, Dehua Lu, Xingchen Liu, Xinye Chen, Lingyi Kong*, Xiaobing Wang*, Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA, Journal of Medicinal Chemistry, 2021, 64: 12630-12650. DOI:10.1021/acs.jmedchem.1c00567 ( Supplementary Cover).
2. Cheng Wang, Shang Li, Jinhua Zhao, Huali Yang, Fucheng Yin, Ming Ding, Jianguang Luo, Xiaobing Wang*, Lingyi Kong*, Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment, Journal of Medicinal Chemistry, 2020, 63: 11195-11214. DOI: 10.1021/acs.jmedchem.0c01128( Supplementary Cover).
3. Jinhua Zhao, Fucheng Yin, Limei Ji, Cheng Wang, Cunjian Shi, Xingchen Liu, Huali Yang, Xiaobing Wang*, Lingyi Kong*, Development of a Tau-Targeted Drug Delivery System Using a Multifunctional Nanoscale Metal–Organic Framework for Alzheimer’s Disease Therapy, ACS Applied Materials & Interfaces, 2020, 12: 44447-44458. DOI:10.1021/acsami.0c11064 (Supplementary Cover)
4. Cun-Jian Shi, Wan Peng, Jin-Hua Zhao, Hua-Li Yang, Lai-Liang Qu, Cheng Wang, Ling-Yi Kong*, Xiao-Bing Wang*, Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors, European Journal of Medicinal Chemistry, 2020, 187: 111961. DOI: 10.1016/j.ejmech.2019.111961
5. Siqiang Fang, Xiaobing Wang*, Fucheng Yin, Pei Cai, Huali Yang, Lingyi Kong*, Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group, Organic Letters, 2019, 21: 1841-1844. DOI: 10.1021/acs.orglett.9b00433
6. Hua-Li Yang, Si-Qiang Fang, Yan-Wei Tang, Cheng Wang, Heng Luo, Lai-Liang Qu, Jin-Hua Zhao, Cun-Jian Shi, Fu-Cheng Yin, Xiao-Bing Wang *, Ling-Yi Kong*, A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer’s disease. European Journal of Medicinal Chemistry, 2019, 179, 736-743.
7. Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. European Journal of Medicinal Chemistry. 2019, 163: 307-319
8. Novel 8-hydroxyquinoline derivatives targeting beta-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease. Bioorganic & Medicinal Chemistry. 2018, 26: 3191-3201
9. Qing-Feng Wu, Xiao-Bing Wang, Peng-Xiang Shen, Jin-Quan Yu, Enantioselective C–H Arylation and Vinylation of Cyclobutyl Carboxylic Amides, ACS Catalysis, 2018, 2577-2581. DOI: 10.1021/acscatal.8b00069 (Q.-F.W. and X.-B.W. contributed equally to this work.)
10. Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. European Journal of Medicinal Chemistry. 2018, 157: 161-176
11. Qing-Feng Wu, Peng-Xiang Shen, Jian He, Xiao-Bing Wang, Forrest Zhang, Qian Shao, Ru-Yi Zhu, Claudio Mapelli, Jennifer X. Qiao, Michael A. Poss, Jin-Quan Yu*, Formation of α-chiral centers by asymmetric β-C(sp3)–H arylation, alkenylation, and alkynylation. Science, 2017, 355, 499-503. DOI: 10.1126/science.aal5175

*以上信息由高级会员个人更新和维护。