王元

男， 河南理工大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1998.9-2002.6，兰州大学化学化工学院，本科生；
2003.9-2008.6，兰州大学化学化工学院，博士研究生；
2008.6-2012.12，河南理工大学化学化工学院，讲师；
2013.1-2021.12，河南理工大学化学化工学院，副教授；
2022.1-至今，河南理工大学化学化工学院，教授。

研究领域和兴趣

分析化学，荧光探针

主要业绩

本人熟悉多种常规荧光染料的制备路线和探针的设计策略，在荧光探针研究领域积累了丰富的经验，在SCI源刊发表相关学术论文多篇，其中包括中科院一区论文7篇，二区论文20余篇，详细业绩如下：
1. 对简单席夫碱化合物的聚集诱导发光（AIE）行为进行了深入研究：开发了基于芘酰腙的聚集诱导发光增强（AEE）活性荧光探针，用于Cu2+的荧光增强检测和HeLa细胞成像；聚集诱导比率发光（AIRE）活性探针在溶液态和聚集态均可对Cu2+选择性识别；AIE活性吡咯双腙席夫碱实现对Hg2+、Zn2+和Cu2+多通道识别，并解析了探针-Hg2+的“3+3”型夹心式配合物的晶体结构。
2. 将亚细胞靶向基团有机整合到荧光团母体，构建了若干亚细胞器靶向荧光探针，实现了对活细胞溶酶体、线粒体和内质网中活性氧（ROS，如过氧化氢、次氯酸）、活性硫（RSS，如硫化氢、亚硫酸氢根）、酶活性、pH和粘度等相关指标的生物成像。
3. 构建了若干针对环境有毒物（如肼、光气和氰根）的荧光探针，尤其是线粒体靶向针对肼的双比率荧光探针，实现了细胞线粒体内内源性和外源性肼的荧光识别。

代表成果

1. Pan Liu, Wei-Na Wu*, Yuan Wang*, Yun-Chang Fan, Zhi-Hong Xu*, A dual-ratiometric mitochondria-targeted fluorescent probe to detect hydrazine in soil samples and biological imaging, Journal of Hazardous Materials 440 (2022) 129713. DOI: 10.1016/j.jhazmat.2022.129713.
2. Ling Zhang, Wei-Na Wu*, Xiao-Lei Zhao, Yun-Chang Fan, Yuan Wang*, Zhi-Hong Xu*, A coumarin/cyanoacetamide-derived lysosome-targeting probe for detecting bisulfite and viscosity changes in living cells and zebrafish, Dyes and Pigments 208 (2022) 110862. DOI: 10.1016/j.dyepig.2022.110862.
3. Fang-Fang Guo1, Wei-Na Wu1, Xiao-Lei Zhao, Yuan Wang*, Yun-Chang Fan, Chuan-Xiang Zhang*, Zhi-Hong Xu*, A water-soluble lysosome-targetable fluorescent probe for carboxylesterase detection and its application in biological imaging, Dyes and Pigments 199 (2022) 110079. DOI: 10.1016/j.dyepig.2022.110079.
4. Ling Zhang1, Jin-Long Yan1, Wei-Na Wu*, Xiao-Lei Zhao, Yuan Wang*, Yun-Chang Fan, Zhi-Hong Xu*, A “turn-on” chalcone-based probe for hydrogen sulfide and imaging applications in lysosomes of living cells and zebrafish, Microchemical Journal 183 (2022) 107941. DOI: 10.1016/j.microc.2022.107941.
5. Yu-Fei Song, Wei-Na Wu*, Yuan Wang*, Xiao-Lei Zhao, Yun-Chang Fan, Zhi-Hong Xu*, Europium (III) complex-based fluorescent probe for instantaneous, selective, and sensitive detection of phosgene, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 280 (2022) 121553. DOI: 10.1016/j.saa.2022.121553.
6. Xiao-Chuang Chang1, Xue-Feng Han1, Bing-Jie Liu, Zi-Yi Jiang, Shuai-Ze Li, Yue-Ming Lv, Ao-Long Li, Yuan Wang*, Wei-Na Wu*, A tosylhydrazone-based probe for the ratiometric fluorescent detection of hypochlorite in endoplasmic reticulum of living cells. Journal of Molecular Structure 1255 (2022) 132382. DOI: 10.1016/j.molstruc.2022.132382.
7. Liang-Liang Gao1, Bei-Bei Wang1, Xi Chen, Yuan Wang*, Wei-Na Wu*, Xiao-Lei Zhao, Ling-Ling Yan, Yun-Chang Fan, Zhi-Hong Xu*, Hydrazone derivative bearing coumarin for the relay detection of Cu2+ and H2S in an almost neat aqueous solution and bioimaging in lysosomes, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 255 (2021) 119693. DOI: 10.1016/j.saa.2021.119693.
8. Yuan Wang1, Yu-Fei Song1, Ling Zhang, Geng-Geng Dai, Rui-Fang Kang, Wei-Na Wu∗, Zhi-Hong Xu∗, Yun-Chang Fan, Lin-Yan Bian, A pyrazole-containing hydrazone for fluorescent imaging of Al3+ in lysosomes and its resultant Al3+ complex as a sensor for F−, Talanta 203 (2019) 178–185. DOI: 10.1016/j.talanta.2019.05.051.
9. Yuan Wang, Hao Wu, Wei-Na Wu∗, Shou-Jie Li, Zhi-Hong Xu∗, Zhou-Qing Xu, Yun-Chang Fan, Xiao-Lei Zhao, Bao-Zhong Liu∗ An AIRE active Schiff base bearing coumarin and pyrrole unit: Cu2+ detection in either solution or aggregation states, Sensors and Actuators B 260 (2018) 106–115. DOI: 10.1016/j.snb.2017.12.201.
10. Wei-Na Wu, Pan-Dong Mao, Yuan Wang∗, Xian-Jie Mao, Zhou-Qing Xu, Zhi-Hong Xu∗, Xiao-Lei Zhao∗, Yun-Chang Fan, Xu-Feng Hou, AEE active Schiff base-bearing pyrene unit and further Cu2+–inducedself-assembly process, Sensors and Actuators B 258 (2018) 393–401. DOI: 10.1016/j.snb.2017.11.114.

*以上信息由高级会员个人更新和维护。