雷春阳

男， 湖南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2004.09-2008.06 湖南大学 生物技术 理学学士
2008.09-2014.09 湖南大学 分析化学 理学博士
2014.10-2017.03 浙江大学 生工食品学院 博士后/助理研究员
2017.03-2019.12 湖南大学 化学化工学院 助理教授
2020.01-2024.12 湖南大学 化学化工学院 副教授
2025.01-至今 湖南大学 化学化工学院 教授

研究领域和兴趣

生物分析化学

主要业绩

雷春阳，湖南大学化学化工学院教授、博士生导师，国家自然科学基金青年科学基金(B类)获得者,分析化学(1)国家级线上线下混合式一流课程团队成员。面向生命与公共安全分析需求，围绕CIRSPR-Cas酶等新型合成生物学工具开展理性分子改造，发展用于生命与环境分析的生物传感新方法。近年来，相关研究成果以通讯作者发表在Angew. Chem. Int. Ed., Adv. Funct. Mater., Chem. Sci., Anal. Chem., Sci. China Chem.等国际国内高水平期刊上，主持国家自然科学基金青年(B类和C类)、面上项目等课题，担任中国毒理学会分析毒理专业委员会青年委员。

代表成果

(1) K. Wang, S. Liu, S. Zhou, A. Qileng, D. Wang, Y. Liu, C. Chen, C. Lei*, Z. Nie*. Ligand-responsive artificial protein-protein communication for field-deployable cell-free biosensing. Angew. Chem. Int. Ed., 2025, 64, e202416671.(Very Important Paper)
(2) B. Xu#, H. Tian#, X. Li, Q. Hao, Y. Ma, L. Liu, C. Lei*, Y. Chen*, Zhou Nie*. On-chip engineered living materials as field-deployable biosensing laboratories for multiplexed detection. Adv. Funct. Mater., 2024, doi: 10.1002/adfm.202416830.
(3) W. Kang, F. Xiao, X. Zhu, X. Ling, S. Xie, R. Li, P. Yu, L. Cao, C. Lei*, Y. Qiu, T. Liu, Z. Nie*. Engineering anti-CRISPR proteins to create CRISPR-Cas protein switches for activatable genome editing and viral protease detection. Angew. Chem. Int. Ed., 2024, 63, e202400599.
(4) S. Xie, C. Zhu, L. Yang, H. Li, H. Zhu, Z. Nie, C. Lei*. Programmable proteolysis-activated transcription for highly sensitive ratiometric electrochemical detection of viral protease. Anal. Chem., 2023, 95,10728–10735.
(5) S. Chen, B. Gong, C. Zhu, C. Lei*, Z. Nie*. Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging. TrAC-Trends Anal. Chem., 2023, 159, 11631.
(6) S. Wang#, Z. Zhang#, R. Tang, F. He, Y. Huang, Z. Nie, C. Lei*. Responsive MXene nanovehicles deliver CRISPR/Cas12a for boolean logic-controlled gene editing. Sci. China Chem., 2022, 65, 2318–2326.
(7) S. Chen, R. Wang, S. Peng, S. Xie, C. Lei*, Y. Huang, Z. Nie*. PAM-less conditional DNA substrates leverage trans-cleavage of CRISPR-Cas12a for versatile live-cell biosensing. Chem. Sci., 2022, 13, 2011–2020.
(8) F. Liu, R. Chen, W. Song, L. Li, C. Lei*, Z. Nie. Modular combination of proteolysis-responsive transcription and spherical nucleic acids for smartphone-based colorimetric detection of protease biomarkers. Anal. Chem., 2021, 93, 3517–3525.
(9) X. Luo, J. Zhao, X. Xie, F. Liu, P. Zeng, C. Lei*, Z. Nie. Proteolysis-responsive rolling circle transcription assay enabling femtomolar sensitivity detection of a target protease biomarker. Anal. Chem., 2020, 92, 16314–16321.
(10) G. Feng#, X. Luo#, X. Lu, S. Xie, L. Deng, W. Kang, F. He, J. Zhang, C. Lei*, B, Lin, Y. Huang, Z. Nie*, S. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment. Angew. Chem. Int. Ed., 2019, 58, 6590−6594. (Very Important Paper, Back Cover)

*以上信息由高级会员个人更新和维护。