何心伟

男， 安徽师范大学， 副教授/副研究员/高级工程师或同等级别

学习/工作经历

1999.9-2003.6 安徽师范大学 本科
2006.9-2009.6 安徽师范大学 硕士
2011.9-2015.6 安徽师范大学 博士
2003.7-至今 安徽师范大学，讲师，副教授
2018.3-2019.3 香港中文大学 访问学者

研究领域和兴趣

有机合成

主要业绩

主要从事过渡金属催化的多组分串联反应和基于邻亚甲基苯醌(o-AQMs)的1,4-共轭加成/分子内环化串联反应合成杂环化合物的方法学研究。围绕具有多反应位点的高活性反应中间体o-AQMs的化学转化及其反应性开展了相关研究，发展了其与不同亲核试剂(如2-萘酚、苯甲酰硫叶立德、α-羰基活泼亚甲基化合物、吡啶叶立德等)的1,4-共轭加成/分子内环化串联新反应及多种结构新颖含氧杂环化合物的合成新方法，研究成果先后在Chem. Sci., Org. Lett., Chem. Commun., Commun. Chem., Adv. Synth. Catal., J. Org. Chem., Org. Biomol. Chem., Tetrahedron等SCI核心期刊上发表。同时在过渡金属催化的重氮化合物的C-H官能化和环加成反应等方面也开展了部分研究工作，并取得了一定研究结果。累计发表SCI研究论文70余篇，获安徽省自然科学技术奖三等奖1项，获授权发明专利7项。主持安徽省自然科学基金2项，安徽省普通高等学校自然科学研究重点项目2项，参与国家自然科学基金项目4项。

代表成果

1. Xinwei He,* Ruxue Li, Pui Ying Choy, Jiahui Duan, Zhenzhen Yin, Keke Xu, Qiang Tang, Rong-Lin Zhong, Yongjia Shang* and Fuk Yee Kwong.* An expeditious FeCl3-catalyzed cascade 1,4-conjugate addition/annulation/1,5-H shift sequence for modular access of all-pyrano-moiety-substituted chromenes. Chem. Sci., 2022, 13, 13617-13622. (DOI: 10.1039/d2sc04431e)
2. Tianyi Liu, Kin Boon Gan, Rong-Lin Zhong, Xinwei He,* and Fuk Yee Kwong.* A Metal-Free and Redox-Neutral Benzylic C−O Cyclization for Succinct Access of Helical Chromenes. Org. Lett., 2022, 24, 6805-6809. (DOI:10.1055/s-0042-1751794)
3. Jiahui Duan, Xinwei He,* Pui Ying Choy, Qi Wang, Mengqing Xie, Ruxue Li, Keke Xu, Yongjia Shang,* Fuk Yee, Kwong.* Cascade Lactonization/Benzannulation of Propargylamines with Dimethyl 3-Oxoglutarate for Modular Assembly of Hydroxylated/Arene-Functionalized Benzo[c]chromen-6-ones. Org. Lett., 2021, 23, 6455-6460.(DOI: 10.1021/acs.orglett.1c02266)
4. Xinwei He,* Ruxue Li, Pui Ying Choy, Mengqing Xie, Jiahui Duan, Qiang Tang, Yongjia Shang,* Fuk Yee, Kwong.* A Cascade Double 1,4-Addition/Intramolecular Annulation Strategy for Expditious Assembly of Unsymmetrical Dibenzofurans. Commun. Chem., 2021, 4, 42. (DOI: 10.1038/s42004-021-00478-2)
5. Xinwei He,* Ruxue Li, Pui Ying Choy, Tianyi Liu, Junya Wang, On Ying Yuen, Man Pan Leung, Yongjia Shang, Fuk Yee, Kwong.* DMAP-Catalyzed Annulation Approach For Modular Assembly of Furan-Fused Chromenes. Org. Lett., 2020, 22, 9444-9449. (DOI: 10.1021/acs.orglett.0c03374)
6. Xinwei He,* Ruxue Li, Pui Ying Choy, Tianyi Liu, On Ying Yuen, Man Pan Leung, Yongjia Shang, Fuk Yee Kwong.* Rapid Access of Alkynyl and Alkenyl Coumarins via a Dipyridinium Methylide and Propargylamine Cascade Reaction. Org. Lett., 2020, 22, 7348-7352.(DOI: 10.1021/acs.orglett.0c02674)
7. Xinwei He,* Mengqing Xie, Ruxue Li, Pui Ying Choy, Qiang Tang, Yongjia Shang, Fuk Yee Kwong.* Organocatalytic Approach for Assembling Flavanones via a Cascade 1,4-Conjugate Addition/oxa-Michael Addition between Propargylamines with Water. Org. Lett. 2020, 22, 4306-4310.(DOI: 10.1021/acs.orglett.0c01357)
8. Youpeng Zuo, Xinwei He,* Qiang Tang, Wangcheng Hu, Tongtong Zhou, Yongjia Shang.* Palladium-Catalyzed Cascade Decarboxylative Amination/6-endo-dig Benzannulation of o-Alkynylarylketones with N-Hydroxyamides To Access Diverse 1-Naphthylamine Derivatives. Org. Lett., 2020, 22, 3890-3894.(DOI: 10.1021/acs.orglett.0c01183)
9. Xinwei He, Pui Ying Choy, Man Pan Leung, On Ying Yuen, Tianyi Liu, Yongjia Shang, Fuk Yee Kwong.* A ZnI2-Catalyzed Regioselective Cascade 1,4-Conjugate Addition/5-exo-dig Annulation Pathway for One-Pot Access to Heterobiaryl Frameworks. Chem. Commun., 2019, 55, 15069-15072.(DOI: 10.1039/c9cc07054k)
10. Qiang Tang, Keke Xu, Xinwei He,* and Yongjia Shang.* Metal-Free Cascade 1,4-Conjugate Addition/Selective Annulation Strategy for Divergent Synthesis of Polysubstituted Imidazoles and 4-Alkenylquinazolines. Adv. Synth. Catal., 2022, 364, 4103-4109.(DOI: 10.1002/adsc.202200905)

*以上信息由高级会员个人更新和维护。