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男, 东华大学, 教授/研究员/教授级高工或同等级别
学习/工作经历
1988.08-1992.07,西北工业大学材料科学与工程系,本科生;
1992.07-1998.12,北京航空材料研究院复合材料研究室,助理工程师、工程师;
1999.01-2001.04,新加坡国立大学机械制造与工程系,硕士研究生;
2002.06-2006.12,新加坡国立大学机械工程系,博士研究生;
2007.01-2007.11,英国布里斯特大学牙科学院,博士后研究助理;
2007.12-2009.06,新加坡国立大学生物医学工程系,研究员;
2009.11至今,东华大学化学化工与生物工程学院,教授
研究领域和兴趣
高分子材料科学与工程;生物材料学;组织工程与再生医学
主要业绩
大学毕业后的1992年至2001年,一直开展纤维增强的树脂基复合材料研究工作,国内工作期间(1992-1998)曾负责研发一种中温固化、韧性、耐湿热的环氧树脂基体及其预浸材料,如今已被用于制备某型号武装直升机;参研的一项国家重点某歼击机复合材料构件也已成功装机使用并获得批量生产。自2002年以来,一直从事纤维生物材料与人体组织器官再生的基础和应用基础研究。致力于采用材料学和仿生学相结合的研究策略,通过合理调控纤维生物材料的理化、生物、结构、力学等要素来模拟(干)细胞生存的微环境,从而增强(干)细胞对生物材料的生物响应特性和对伤病(血管、肌腱、神经、骨、软骨等)组织的再生修复能力。主要学术贡献:是国际上亚洲地区最早从事电纺丝(Electrospinning)及其在组织工程与再生医学(TERM)中应用的学者之一,尤其在生物可降解天然-合成复合纳米纤维组织工程支架、同轴共电纺壳-芯结构复合纳米纤维的制备与应用、有机-无机杂化复合纳米纤维用于骨组织工程、形状记忆仿生纤维、及仿生纤维的力学生物学作用机制等方向开展了一系列具有开创性和一定国际影响力的研究工作。已在相关领域的主流学术刊物上发表研究论文110余篇,撰写4本英文专著的章节,获授权国内外发明专利8件。发表的SCI论文被引用15,000余次,引用100次以上的论文28篇,H-指数=45。有12篇SCI论文曾被列为ESI高引用论文“Highly Cited Papers”(即引用Top1%论文)。回国工作以来主持了上海市“浦江人才计划”项目、国家自然科学基金面上项目(4项)、上海市科委基础研究重点项目等重要科研项目10余项。已指导毕业硕、博士研究生34名,2015、2016连续两年为上海市研究生优秀学位论文指导教师。主讲《生物材料》、《医用高分子材料》、《生物材料与组织工程》等课程。
代表成果
1. Y.B. Shen, Y. Xu, B.C. Yi, X.L. Wang, H. Tang, C. Chen*, Y.Z. Zhang*, Engineering a Highly Biomimetic Chitosan-Based Cartilage Scaffold by Using Short Fibers and a Cartilage-Decellularized Matrix, Biomacromolecules 22 (2021) 2284-2297.(Q1,IF2020=6.988)
2. H. Tang, B.C. Yi, X.L. Wang, Y.B. Shen, Y.Z. Zhang*, Understanding the cellular responses based on low-density electrospun fiber networks, Materials Science & Engineering C-Materials for Biological Applications 119 (2021) 111470. (Q1,IF2020=7.328)
3. X.L. Wang, H.Y. Yan, Y.B. Shen, H. Tang, B.C. Yi, C.P. Qin, Y.Z. Zhang*, Shape memory and osteogenesis capabilities of the electrospun poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) modified poly(l-Lactide) fibrous mats, Tissue Engineering Part A 27 (2021) 142-152. (Q2,IF2020=3.845)
4. T. Tu, Y.B. Shen, X.S. Wang, W.J. Zhang, G.D. Zhou, Y.Z. Zhang*, W.B. Wang*, W. Liu*, Tendon ECM modified bioactive electrospun fibers promote MSC tenogenic differentiation and tendon regeneration, Applied Materials Today, 18 (2020) 100495.(Q1,IF2020=10.041)
5. B.C. Yi, Y.B. Shen, H. Tang, X.L. Wang, Y.Z. Zhang*, Stiffness of the aligned fibers affects structural and functional integrity of the oriented endothelial cells, Acta Biomaterialia 108 (2020) 237-249.(Q1,IF2020=8.947)
6. B.C. Yi, Y.B. Shen, H. Tang, X.L. Wang, B. Li*, Y.Z. Zhang*, Stiffness of aligned fibers regulates the phenotypic expression of vascular smooth muscle cells, ACS Applied Materials & Interfaces 11(7) (2019) 6867-6880. (Q1,IF2020=9.229)
7. Y.B. Shen, T. Tu, B.C. Yi, X.L. Wang, H. Tang, W. Liu*, Y.Z. Zhang*, Electrospun acid-neutralizing fibers for the amelioration of inflammatory response, Acta Biomaterialia 97 (2019) 200-215. (Q1,IF2020=8.947)
8. C. Zhang, X.L. Wang, E.C. Zhang, L. Yang, H.H. Yuan, W.J. Tu, H.L. Zhang, Z. Yin, W.L. Shen, X. Chen, Y.Z. Zhang*, H.W. Ouyang*, An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering, Acta Biomaterialia 66 (2018) 141-156. (Q1,IF2020=8.947)
9. B.C. Yi, H.L. Zhang, Z.P. Yu, H.H. Yuan, X.L. Wang, Y.Z. Zhang*, Fabrication of high performance silk fibroin fibers via stable jet electrospinning for potential use in anisotropic tissue regeneration, Journal of Materials Chemistry B 6(23) (2018) 3934-3945. (Q2,IF2020=6.331)
10. H.H. Yuan, Y.X. Zhou, M.-S. Lee, Y.Z. Zhang*, W.-J. Li*, A newly identified mechanism involved in regulation of human mesenchymal stem cells by fibrous substrate stiffness, Acta Biomaterialia 42 (2016) 247-257. (Q1,IF2020=8.947)
11. H.H. Yuan, J.B. Qin, J. Xie, B.Y. Li, Z.P. Yu, Z.Y. Peng, B.C. Yi, X.X. Lou, X.W. Lu*, Y.Z. Zhang*, Highly aligned core-shell structured nanofibers for promoting phenotypic expression of vSMCs for vascular regeneration, Nanoscale 8(36) (2016) 16307-16322. (Q1,IF2020=7.790)
12. J. Xie, C. Peng, Q.H. Zhao, X.L. Wang, H.H. Yuan, L.L. Yang, K. Li, X.X. Lou*, Y.Z. Zhang*, Osteogenic differentiation and bone regeneration of iPSC-MSCs supported by a biomimetic nanofibrous scaffold, Acta Biomaterialia 29 (2016) 365-379. (Q1,IF2020=8.947)
13. M. Bao, X.L. Wang, H.H. Yuan, X.X. Lou, Q.H. Zhao, Y.Z. Zhang*, HAp incorporated ultrafine polymeric fibers with shape memory effect for potential use in bone screw hole healing, Journal of Materials Chemistry B 4(31) (2016) 5308-5320. (Q2,IF2020=6.331)
14. Q.H. Zhou, J. Xie, M. Bao, H.H. Yuan, Z.Y. Ye, X.X. Lou, Y.Z. Zhang*, Engineering aligned electrospun PLLA microfibers with nano-porous surface nanotopography for modulating the responses of vascular smooth muscle cells, Journal of Materials Chemistry B 3(21) (2015) 4439-4450. (Q2,IF2020=6.331)
15. C. Zhang, H.H. Yuan, H.H. Liu, X. Chen, P. Lu, T. Zhu, L. Yang, Z. Yin, B.C. Heng, Y.Z. Zhang*, H.W. Ouyang*, Well-aligned chitosan-based ultrafine fibers committed teno-lineage differentiation of human induced pluripotent stem cells for Achilles tendon regeneration, Biomaterials 53 (2015) 716-730. (Q1,IF2020=12.479)
16. H.H. Yuan, Q.H. Zhou, B.Y. Li, M. Bao, X.X. Lou, Y.Z. Zhang*, Direct printing of patterned three-dimensional ultrafine fibrous scaffolds by stable jet electrospinning for cellular ingrowth, Biofabrication 7(4) (2015) 45004. (Q1,IF2020=9.954)
17. M. Bao, X.X. Lou, Q.H. Zhou, W. Dong, H.H. Yuan, Y.Z. Zhang*, Electrospun Biomimetic Fibrous Scaffold from Shape Memory Polymer of PDLLA-co-TMC for Bone Tissue Engineering, ACS Applied Materials & Interfaces 6(4) (2014) 2611-2621. (Q1,IF2020=9.229)
18. S.F. Zhao, Q.H. Zhou, Y.-Z. Long*, G.-H. Sun, Y.Z. Zhang*, Nanofibrous patterns by direct electrospinning of nanofibers onto topographically structured non-conductive substrates, Nanoscale 5(11) (2013) 4993-5000. (Q1,IF2020=7.790)
19. J.X. Xue, B. Feng, R. Zheng, Y. Lu, G.D. Zhou, W. Liu, Y.L. Cao, Y.Z. Zhang*, W.J. Zhang*, Engineering ear-shaped cartilage using electrospun fibrous membranes of gelatin/polycaprolactone, Biomaterials 34(11) (2013) 2624-2631. (Q1,IF2020=12.479)
20. H.H. Liu, H.J. Peng, Y. Wu, C. Zhang, Y.Z. Cai, G.W. Xu, Q. Li, X. Chen, J.F. Ji, Y.Z. Zhang*, H.W. Ouyang*, The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs, Biomaterials 34(18) (2013) 4404-4417. (Q1,IF2020=12.479)
21. M. Bao, Q.H. Zhou, W. Dong, X.X. Lou, Y.Z. Zhang*, Ultrasound-modulated shape memory and payload release effects in a biodegradable cylindrical rod made of chitosan-functionalized PLGA microspheres, Biomacromolecules 14(6) (2013) 1971-1979. (Q1,IF2020=6.988)
22. H.H. Yuan, S.F. Zhao, H.B. Tu, B.Y. Li, Q. Li, B. Feng, H.J. Peng, Y.Z. Zhang*, Stable jet electrospinning for easy fabrication of aligned ultrafine fibers, Journal of Materials Chemistry 22(37) (2012) 19634-19638. (Q1,IF2013=6.626)
23. B. Feng, H.B. Tu, H.H. Yuan, H.J. Peng, Y.Z. Zhang*, Acetic-acid-mediated miscibility toward electrospinning homogeneous composite nanofibers of GT/PCL, Biomacromolecules 13(12) (2012) 3917-3925. (Q1,IF2020=6.988)
24. Y.Z. Zhang, V.J. Reddy, S.Y. Wong, X. Li, B. Su, S. Ramakrishna, C.T. Lim*, Enhanced Biomineralization in Osteoblasts on a Novel Electrospun Biocomposite Nanofibrous Substrate of Hydroxyapatite/Collagen/Chitosan, Tissue Engineering Part A 16(6) (2010) 1949-1960. (Q2,IF2020=3.845)
25. Y.Z. Zhang*, B. Su, S. Ramakrishna, C.T. Lim, Chitosan nanofibers from an easily electrospinnable UHMWPEO-doped chitosan solution system, Biomacromolecules 9(1) (2008) 136-141. (Q1,IF2020=6.988)
26. Y.Z. Zhang, J.R. Venugopal, A. El-Turki, S. Ramakrishna, B. Su*, C.T. Lim*, Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering, Biomaterials 29(32) (2008) 4314-4322. (Q1,IF2020=12.479)
27. Y.Z. Zhang*, X. Wang, Y. Feng, J. Li, C.T. Lim, S. Ramakrishna, Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release, Biomacromolecules 7(4) (2006) 1049-1057. (Q1,IF2020=6.988)
28. Y.Z. Zhang*, J. Venugopal, Z.M. Huang, C.T. Lim, S. Ramakrishna, Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblasts, Biomacromolecules 6(5) (2005) 2583-2589. (Q1,IF2020=6.988)
29. Y.Z. Zhang*, H.W. Ouyang, C.T. Lim, S. Ramakrishna, Z.M. Huang, Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds, Journal of Biomedical Materials Research Part B-Applied Biomaterials 72B(1) (2005) 156-165. (Q2,IF2020=3.368, 该文为该期刊引用数最高的论文)
30. Y.Z. Zhang*, Z.M. Huang*, X.J. Xu, C.T. Lim, S. Ramakrishna, Preparation of core-shell structured PCL-r-gelatin Bi-component nanofibers by coaxial electrospinning, Chemistry of Materials 16(18) (2004) 3406-3409. (Q1,IF2020=9.811)
*以上信息由高级会员个人更新和维护。