牛丽亚

女， 北京师范大学， 副教授/副研究员/高级工程师或同等级别

学习/工作经历

2003.09– 2007.06：北京航空航天大学材料科学与工程学院，学士
2007.09– 2010.03：北京航空航天大学化学与环境学院，硕士
2010.09– 2013.06：中国科学院理化技术研究所，博士
2013.07–2016.03：中国科学院理化技术研究所，助理研究员
2016.04–至今：北京师范大学，化学学院，讲师，副教授

研究领域和兴趣

荧光探针和诊疗试剂

主要业绩

长期致力于开发荧光探针及光学诊疗试剂，并研究其在荧光成像及疾病诊疗方面的应用，主要取得了以下创新性成果：
（1）提出了“芳香亲核取代-分子内重排”的探针设计策略作为选择性检测谷胱甘肽的通用方法，解决了谷胱甘肽和半胱氨酸、同型半胱氨酸难以区分检测的难题。基于此策略设计合成了一系列选择性检测谷胱甘肽和相关生物活性分子的荧光探针，并应用于细胞及活体中的可视化成像。
（2）提出了“组装调控活性氧生成”机制用于构建超分子光学诊疗试剂，突破了小分子诊疗试剂暗毒性高、乏氧不耐受等局限。基于此策略开发了一系列超分子光敏剂，并应用于光动力治疗及其机制研究。
申请人以第一/通讯作者发表学术论文36篇，包括J. Am. Chem. Soc.、Adv. Mater.、Chem. Soc. Rev.、 CCS. Chem.、Chem. Sci.、Anal. Chem.等，2篇论文入围ESI高被引论文，获国家发明专利3项。

代表成果

1. Kun-Xu Teng, Li-Ya Niu* and Qing-Zheng Yang*, Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy, J. Am. Chem. Soc. 2023, 145, 4081-4087.
2. Dongsheng Zhang, Kun-Xu Teng, Luyang Zhao, Li-Ya Niu* and Qing-Zheng Yang*, Ultra-small Nano-assemblies as Tumor-targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy, Adv. Mater. 2023, DOI: 10.1002/adma.202209789.

3. Dongsheng Zhang†, Ling-Ya Peng†, Kun-Xu Teng, Li-Ya Niu*, Ganglong Cui*, and Qing-Zheng Yang*, Self-Assembly Regulated Singlet Oxygen Generation of Heavy-Atom-Free Organic Chromophores, ACS Materials Lett. 2023, 5, 180-188.

4. Xiao-Xiao Chen†, Yufei Wu†, Xiaoxiao Ge, Liandi Lei, Li-Ya Niu*, Qing-Zheng Yang* and Lemin Zheng*, In Vivo Imaging of Heart Failure with Preserved Ejection Fraction by Simultaneous Monitoring of Cardiac Nitric Oxide and Glutathione Using a Three-channel Fluorescent Probe, Biosens. Bioelectron., 2022, 214, 114510.

5. Yan-Fei Kang, Wen-Kai Chen, Kun-Xu Teng, Ling-Yun Wang, Xiao-Cheng Xu, Li-Ya Niu,* Ganglong Cui* and Qing-Zheng Yang*, Aggregation turns BODIPY fluorophores into photosensitizers: reversibly switching intersystem crossing on-and-off for smart photodynamic therapy, CCS Chem, 2022, 4, 3516-3528.

6. Xiao-Xiao Chen, Li-Ya Niu* and Qing-Zheng Yang*, Visualizing the Underlying Signaling Pathway Related to Nitric Oxide and Glutathione in Cardiovascular Disease Therapy by a Sequentially Activated Fluorescent Probe, Anal. Chem., 2021, 93, 3922-3928.

7. Kun-Xu Teng, Li-Ya Niu,* Yan-Fei Kang, and Qing-Zheng Yang,* Rational Design of a “Dual Lock-and-Key” Supramolecular Photosensitizer Based on Aromatic Nucleophilic Substitution for Specific and Enhanced Photodynamic Therapy, Chem. Sci., 2020, 11, 9703–9711.

8. Xin Zhu, Jian-Xin Wang, Li-Ya Niu,* Qing-Zheng Yang*, Aggregation-Induced Emission Materials with Narrowed Emission Band by Light-Harvesting Strategy: Fluorescence and Chemiluminescence Imaging, Chem. Mater. 2019, 31, ‏ 3573-358.

9. Li-Ya Niu, Yu-Zhe Chen, Hai-Rong Zheng, Li-Zhu Wu, Chen-Ho Tung and Qing-Zheng Yang*, Design Strategies of Fluorescent Probes for Selective Detection Among Biothiols, Chem. Soc. Rev. 2015, 44, 6143-6160.

10. Li-Ya Niu, Ying-Shi Guan, Yu-Zhe Chen, Li-Zhu Wu, Chen-Ho Tung and Qing-Zheng Yang* BODIPY-Based Ratiometric Fluorescent Sensor for Highly Selective Detection of Glutathione over Cysteine and Homocysteine J. Am. Chem. Soc. 2012, 134, 18928−18931.

*以上信息由高级会员个人更新和维护。