裴玉新

女， 西北农林科技大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1.学习经历

(1) 1984-09至1988-06，郑州大学，化学，学士；

(2) 1988-09至1991-06，郑州大学，化学，硕士；

(3) 1995-02至1998-03，东华大学，化学纤维专业，博士；

2.工作经历

(1) 1998-04至2000-04，浙江大学，博士后；

(2) 2000-05至2001-12，Lund University，博士后；

(3) 2002-01至2003-03，Technical University of Denmark，博士后；

(4) 2003-04至2010-06，Royal Institute of Technology，博士后；

(5) 2006-06至2007-06，Universitatsklinikum Heidelberg，博士后；

(6) 1991-10至1994-10，郑州大学，材料系，助教；

(7) 1994-11至1995-01，郑州大学，材料系，讲师；

(8) 2010-07至2016-12，西北农林科技大学，理学院，教授；

(9) 2017-01至今，西北农林科技大学，化学与药学院化学系，教授。

研究领域和兴趣

基于超分子化学的智能纳米功能材料的构筑及应用： 1.糖基靶向药物递送系统； 2.有机-无机杂化纳米药物； 3.药物实时示踪、肿瘤细胞检测及生物成像。

主要业绩

三级教授，博士生导师。多年来致力于超分子自组装和靶向药物递送研究，已在基于可控超分子组装实现“智能”糖靶向纳米药物载体的构建及其应用于靶向肿瘤研究方面取得了系列创新性研究成果，在Angew. Chem. Int. Ed., Adv. Sci, Adv. Funct. Mater. Chem Sci. 等国际著名期刊发表高水平论文100余篇，主持国家级、省部级等研究课题10余项，获批发明专利6项。中国生物化学与分子生物学会复合糖专业委员会委员，中国生化制药工业协会糖类药物分会专家委员会委员。

代表成果

1.Jiaxuan Li, Yanqing Li, Yi Wang, Wenjuan Jin, Zhichao Pei*, Yinghua Lv*, and Yuxin Pei*. A proton pump inhibitor-programmed ROS generator enhances the synergistic efficacy of chemo-/chemodynamic therapy with reduced renal injury, Chem. Eng. J., 159201 (505) (2025). DOI: 10.1016/j.cej.2024.159201；
2.Jiaxuan Li, Zelong Chen, Zhichao Pei*, Yuxin Pei*. A hyaluronic acid modified advanced nanoagent activated by tumor microenvironment enables a reciprocal dual-modality therapy. Chem. Eng. J., 159884 (507) (2025). DOI: 10.1016/j.cej.2025.159884；
3.Shangqian Zhang, Jiaxuan Li, Xuan Hu, Zelong Chen, Junliang Dong, Chenhao Hu, Shuang Chao, Yinghua Lv, Yuxin Pei*, Zhichao Pei*. H2S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis. Chin. Chem. Lett., 110314 (36) (2025). DOI: 10.1016/j.cclet.2024.110314；
4.Yi Wang, Zelong Chen, Jiahui Li, Yafei Wen, Jiaxuan Li, Yinghua Lv, Zhichao Pei,* Yuxin Pei*. A paramagnetic metal-organic framework enhances mild magnetic hyperthermia therapy by downregulating heat shock proteins and promoting ferroptosis via aggravation of two-way regulated redox dyshomeostasis. Adv. Sci, 306178, (11) (2023), DOI: 10.1002/advs.202306178；
5.Jiaxuan Li, Baifei Hu, Zelong Chen, Jiahui Li, Wenjuan Jin, Yi Wang, Yichen Wan，Yinghua Lv，Yuxin Pei,* Hongtao Liu,* Zhichao Pei*. Mn (III)-mediated carbon-centered radicals generate an enhanced immunotherapeutic effect. Chem Sci. 15, 765-777 (15) (2023), DOI: 10.1039/d3sc03635a；
6.Yun Qu, Wenjuan Jin, Yichen Wan, Zhichao Pei, Yuxin Pei*. J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery. Chin. Chem. Lett., 108493 (35) (2024). DOI: 10.1016/j.cclet.2023.108493；
7.Xiaojiao Di, Zhichao Pei, Yuxin Pei*, Tony D. James*. Tumor microenvironment-oriented MOFs for chemodynamic therapy. Coord. Chem. Rev. 2023, 484: 215098 (484) (2023). DOI: 10.1016/j.ccr.2023.215098；
8.Jiaxuan Li, Xiaomeng Lv, Jiahui Li, Wenjuan Jin, Zelong Chen, Yafei Wen, Zhichao Pei and Yuxin Pei*. A supramolecular near-infrared nanophotosensitizer from host-guest complex of lactose-capped pillar[5]arene with aza-BODIPY derivative for tumor eradication. Org. Chem. Front., 1927-1935 (10) (2023). DOI: 10.1039/d3qo00065f；
9.Yincheng Chang,† Yinghua Lv,† Peng Wei, Pengfei Zhang, Liang Pu, Xiaoxu Chen, Kui Yang, Xueliang Li, Yuchao Lu, Chenxi Hou, Yuxin Pei,* Wenxian Zeng,* Zhichao Pei*. Multifunctional glyco nanofibers: siRNA induced supermolecular assembly for codelivery in vivo. Adv Funct Mater, 1703083 (27) (2017). DOI: 10.1002/adfm.201703083;
10.Yincheng Chang, Kui Yang, Peng Wei, Sisi Huang, Yuxin Pei,* Wei Zhao, Zhichao Pei*. Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: A redox-responsive system for drug/siRNA co-delivery. Angew. Chem. Int. Ed, 13126-13130 (53) (2014). DOI: 10.1002/ange.201407272;

*以上信息由高级会员个人更新和维护。