王浩

男， 国家纳米科学中心， 教授/研究员/教授级高工或同等级别

学习/工作经历

1996.09-2000.07， 南开大学化学学院，本科学生
2000.09-2005.07， 南开大学化学学院，博士研究生
2005.09-2007.07， 德国维尔茨堡大学化学院，洪堡学者
2007.09-2011.08， 美国UCLA药学院，博士后/研究助理
2011.09-至今， 国家纳米科学中心，研究员

研究领域和兴趣

高分子生物材料，化学生物学，超分子化学

主要业绩

针对生物医用高分子材料和生物化学中的问题，围绕多肽及其聚合物，开展系统性研究包括：1.多肽聚合物材料的靶向性筛选
发展高通量合成和筛选平台，实现对载体材料靶向性快速优选；2.多肽聚合材料的响应性富集设计响应性单元，通过“活体自组装” 实现富集；3.提出“组装诱导滞留”效应，实现高效药物递送。获得国家万人计划领军人才（2018），国家杰出青年基金获得者（2017），科技部中青年科技创新领军人才（2017），中科院创新交叉团队负责人（2017），国家自然科学基金创新群体骨干（2017），中科院百人计划结题优秀（2016），中科院百人计划获得者（2012）。

代表成果

[1] Pei-Pei Yang #, Kuo Zhang#, Ping-Ping He , Yu Fan, Xuejiao J. Gao , Xingfa Gao , Zi-Ming Chen, Da-Yong Hou, Yuan Li, Yu Yi, Dong-Bing Cheng, Jing-Ping Zhang, Linqi Shi, Xian-Zheng Zhang, Lei Wang*, Hao Wang*. A biomimetic platelet based on assembling peptides initiates artificial coagulation. Sci. Adv., 2020, 6, eaaz4107
[2] Ping-Ping He, Xiang-Dan Li*, Lei Wang*, Hao Wang*. Bispyrene-Based Self-Assembled Nanomaterials: In Vivo Self-Assembly, Transformation, and Biomedical Effects. Acc. Chem. Res., 2019, 52(2), 367-378
[3] Dong-Bing Cheng, Dong Wang, Yu-Juan Gao, Lei Wang, Zeng-Ying Qiao*, and Hao Wang*. Autocatalytic Morphology Transformation Platform for Targeted Drug Accumulation. J. Am. Chem. Soc., 2019, 141 (10), 4406-4411
[4] Dong-Bing Cheng, Xue-Hao Zhang, Yu-Juan Gao, Lei Ji, Dayong Hou, Ziqi Wang, Wanhai Xu, Zeng-Ying Qiao*, Hao Wang*. Endogenous Reactive Oxygen Species-Triggered Morphology Transformation for Enhanced Cooperative Interaction with Mitochondria. J. Am. Chem. Soc., 2019, 141(18), 7235-7239.
[5] Yong Cong#, Lei Ji#, Yu-Juan Gao, Fu-Hua Liu, Dong-Bing Cheng, Zhiyuan Hu*, ZengYing Qiao*, and Hao Wang*. Microenvironment-Induced In Situ Self-Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply. Angew. Chem. Int. Ed., 2019, 58(14), 4632-4637.
[6] Hong-Wei An, Li-Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao-Xin Lin, Sheng-Lin Qiao, Man-Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao-Xiao Zhao, Qian Cai, Wen-Ting Chen, Chu-Qi Lu, Wanhai Xu*, Hao Wang* & Yuliang Zhao*. A tumour-selective cascade activatable selfdetained system for drug delivery and cancer imaging. Nat. Commun., 2019, 10(1), 4861.
[7] Guo-Bin Qi, Yu-Juan Gao, Lei Wang,* and Hao Wang.* Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy. Adv. Mater., 2018, 30 (22), 1703444
[8] Yi Wang, Yao-Xin Lin, Sheng-Lin Qiao, Hong-Wei An, Yang Ma, Zeng-Ying Qiao, R.P.Yeshan J. Rajapaksha, Hao Wang*, Polymeric Nanoparticles Promote Macrophage Reversal From M2 to M1 Phenotypes In The Tumor Microenvironment. Biomaterials, 2017, 112, 153-163.
[9]. Self-Assembled ROS-Sensitive Polymer–Peptide Therapeutics Incorporating Built-in Reporters for Evaluation of Treatment Efficacy, Zeng-Ying Qiao, Wen-Jing Zhao, Yong Cong, Di Zhang, Zhiyuan Hu, Zhong-Yu Duan, and Hao Wang*, Biomacromolecules, 2016, 17(5), 1643-1652.
[10] In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and The Assembly-Induced Retention Effect in Tumor Sites. Di Zhang, Guo-Bin Qi, Ying-Xi Zhao, Sheng-Lin Qiao, Chao Yang, and Hao Wang*. Adv. Mater. 2015, 27, 6125-6130

*以上信息由高级会员个人更新和维护。