王宏飞

男， 山西大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1986.09-1990.07 山西大学化学系 本科学生
1990.09-1993.07 山西大学分子所 硕士学生
1993.09-1996.07 南京大学化学化工学院 博士学生
1998.04-2001.03 日本立教大学化学研究科 博士学生
2001.07-2003.03 日本理化学研究所基因科学研究中心 博士后
2003.04-2009.03 日本理化学研究所生命分子系统研究领域 特别研究员
2009.10-2010.09 中科院生物物理研究所 副研究员
2010.10- 至今 山西大学分子所 教授

研究领域和兴趣

化学生物学 结构生物学

主要业绩

2012年入选山西省引进海外高层次人才“百人计划”。 2014年入选山西省学术技术带头人。2018年入选三晋英才拔尖骨干人才计划。中国化学会生物物理化学专业委员会委员，中国光学会生物医学光子学专业委员会委员。主持和完成国家以及省部级研究项目十余项，研究成果发表在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等国际知名学术刊物。

代表成果

1. Leilei Xie, Hehe Bai, Luna Song, Chenyang Liu, Wenjun Gong, Wenming Wang, Xuan Zhao, Chie Takemoto, Hongfei Wang. Structural and Photodynamic Studies on Nitrosylruthenium-Complexed Serum Albumin as a Delivery System for Controlled NO Release, Inorg Chem. 2021, 60, 8826−8837.
2. Xiaorong Zhang, Yu Liu, Bowen Zheng , Jiachen Zang, Chenyan Lv, Tuo Zhang, Hongfei Wang , Guanghua Zhao. Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials. Nat Commun. 2021,12(1):4849.
3. Wenming Wang, Yao Zhang, Guanghua Zhao, Hongfei Wang. Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe2+ Uptake from Mycoplasma, Inorg Chem. 2021, 60, 7207-7216.
4. Luna Song, Hehe Bai, Chenyang Liu, Wenjun Gong, Ai Wang, Li Wang, Yi Zhao, Xuan Zhao, Hongfei Wang. Synthesis, Biomacromolecular Interactions, Photodynamic NO Releasing and Cellular Imaging of Two [RuCl(qn)(Lbpy)(NO)]X Complexes, Molecules 2021, 26, 2545.
5. Qi Jing, Lifang Liu, Yu Zhang, Leilei Xie, Luna Song, Wenming Wang, Yanhong Liu, Xuan Zhao, Hongfei Wang. Structure, photodynamic reaction and DNA photocleavage properties of a nitrosyl iron-sulfur cluster (Me4N)2[Fe2S2(NO)4]: A DFT calculation and experimental study, Spectrochim Acta A Mol Biomol Spectrosc. 2020,238,118401.
6. Wenming Wang, Fengmei Zhao, Yarui Zhao, Weiwei Pan, Pengcheng Cao, Lintao Wu , Zhijun Wang, Xuan Zhao, Yi Zhao, Hongfei Wang. Design, Synthesis, And Preliminary Bioactivity Evaluation Of 2,7-Substituted Carbazole Derivatives As Potent Autotaxin Inhibitors And Antitumor Agents. Anticancer Agents Med Chem. 2019, 2(19), 256-264.
7. Wenming Wang, Lele Wang, Guobang Li, Guanghua Zhao, Xuan Zhao, Hongfei Wang. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions. Chem Commun. 2019, 55, 12344-12347.
8. Wenming Wang, Lele Wang, Hai Chen, Jiacen Zang, Xuan Zhao, Guanghua Zhao, Hongfei Wang. Selective Elimination of the Key Subunit Interfaces Facilitates Conversion of Native 24-mer Protein Nanocage into 8-mer Nanorings. J Am Chem Soc. 2018, 140, 14078-14081.
9. Shengli Zhang, Jiachen Zang, Wenming Wang, Hai Chen, Xiaorong Zhang, Fudi Wang, Hongfei Wang, Guanghua Zhao. Conversion of Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues. Angew. Chem. Int. Ed. 2016, 55, 16064 -16070.
10. Tomonari Muramatsu, Chie Takemoto, Yong-Tae Kim, Hongfei Wang, Wataru Nishii, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama. SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity. Proc Natl Acad Sci USA. 2016, 113: 12997-13002.

*以上信息由高级会员个人更新和维护。