史雷

男， 哈尔滨工业大学（深圳）， 教授/研究员/教授级高工或同等级别

学习/工作经历

1996.09-2000.07，兰州大学化学化工学院，本科
2000.09-2005.06，兰州大学化学化工学院，博士
2005.09-2006.06，德国亚琛工业大学，博士后
2006.09-2009.02，德国慕尼黑大学，洪堡学者
2009.09-2011.09，英国牛津大学，欧盟玛丽居里学者
2011.10-2017.05，哈尔滨工业大学，教授
2017.06-至今，哈尔滨工业大学（深圳），理学院，教授

研究领域和兴趣

有机合成化学，不对称催化

主要业绩

主要研究方向为基于氧化/还原策略的新试剂、新反应及机理研究，基于重要优势骨架的不对称催化合成研究。着重利用非共价相互作用驱动的锚定策略和活性中间体的精准时空调控手段，开展功能导向的结构设计和结构导向的精准合成，并积极探索相关反应或方法在功能有机分子及其核心骨架的高效合成、规模化制备中的应用潜能。迄今发表研究论文50余篇，获授权中国专利3项，入选教育部新世纪优秀人才支持计划（2012年）。

代表成果

1. Robert Li-Yuan Bao, Lei Shi*, and Kang Fu. Highly Enantioselective Construction of CF3-Bearing All-Carbon Quaternary Stereocenters: Chiral Spiro-Fused Bisoxazoline Ligands with 1,1′-Binaphthyl Sidearm for Asymmetric Michael-Type Friedel-Crafts Reaction. Chin. Chem. Lett. 10.1016/j.cclet.2021.10.062.
2. Rong Zhao, Kang Fu, Yuanding Fang, Jia Zhou,* and Lei Shi*. Site-Specific C(sp3)−H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions. Angew. Chem., Int. Ed. 2020, 59, 20682−20690.
3. Robert Li-Yuan Bao,+ Junjie Yin,+ Lei Shi*, Limin Zheng. Rh(I)-Catalyzed enantioselective and scalable [4+2] cycloaddition of 1,3-dienes with dialkyl acetylenedicarboxylates. Org. Biomol. Chem. 2020, 18, 2956-2961.
4. Dan Zhu, Shaoyan Gan, Robert Li-Yuan Bao, Lei Shi*. Copper-catalyzed cross-coupling of vinyliodonium salts and diboron reagents to generate alkenyl boronic esters. Org. Biomol. Chem. 2020, 18, 5567-5570.
5. Dan Zhu, Lei Shi*. Ni-catalyzed cross-coupling of aryl thioethers with alkyl Grignard reagents via C–S bond cleavage. Chem. Commun. 2018, 54(67), 9313-9316.
6. Yiliang Zhang, Li He, Lei Shi*. Chiral Ion-pair Organocatalyst Promoted Efficient Enantio-selective Reduction of α-Hydroxy Ketones. Adv. Synth. Catal. 2018, 360(10), 1926-1931.
7. Denghu Chang, Rong Zhao, Congwei Wei, Yuan Yao, Yang Liu, Lei Shi*. Sulfonamide-Directed Chemo- and Site-Selective Oxidative Halogenation/Amination Using Halogenating Reagents Generated in situ from Cyclic Diacyl Peroxides. J. Org. Chem. 2018, 83(6), 3305-3315.
8. Dan Zhu, Yuan Yao, Rong Zhao, Yang Liu, Lei Shi*. Metal-Free Geminal Difunctionalization of Diazocarbonyl Compounds: A One-Pot Multicomponent Strategy for the Construction of α,β-Diamino Carbonyl Derivatives. Chem. Eur. J. 2018, 24(19), 4805-4809.
9. Rong Zhao,+ Yuan Yao,+ Dan. Zhu, Denghu Chang, Yang Liu, Lei Shi*. Visible-Light-Enhanced Ring Opening of Cycloalkanols Enabled by Brønsted Base-Tethered Acyloxy Radical Induced Hydrogen Atom Transfer-Electron Transfer. Org. Lett. 2018, 20(4), 1228-1231.
10. Fangwei Ding, Yiliang Zhang, Rong Zhao, Yanqiu Jiang, Robert Li-Yuan Bao, Kaifeng Lin, Lei Shi*. B(C6F5)3-promoted hydrogenations of N-heterocycles with ammonia borane. Chem. Commun. 2017, 53, 9262-9264.

*以上信息由高级会员个人更新和维护。